Monophosphate Derivatives of Luteolin and Apigenin as Efficient Precursors with Improved Oral Bioavailability in Rats

Antioxidants, Год журнала: 2024, Номер 13(12), С. 1530 - 1530

Опубликована: Дек. 13, 2024

Luteolin (Lut) and apigenin (Apn), flavones present in various edible plants, exhibit diverse antioxidant pharmacological activities but have limited vivo efficacy due to low water solubility poor bioavailability. Here, we generated luteolin monophosphate derivatives (LutPs ApnPs) individually via microbial biotransformation. We then characterized their physicochemical properties evaluated vitro pharmacokinetics Both LutPs ApnPs showed enhanced dissolution remained stable simulated gastrointestinal conditions. Additionally, they efficiently reverted parental forms alkaline phosphatase Caco-2 cells. Following oral administration rats, exhibited higher plasma exposure both aglycone conjugated compared Lut Apn. Notably, the biotransformation of Apn was observed all apigenin-related groups. Our study suggests that flavone monophosphates are effective alternatives with bioavailability, providing insights for potential application emerging bioactive nutraceuticals.

Язык: Английский

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Inhibitory Effects of Gliadin Hydrolysates on BACE1 Expression and APP Processing to Prevent Aβ Aggregation

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 13212 - 13212

Опубликована: Дек. 9, 2024

Alzheimer's disease (AD), a leading neurodegenerative disorder, is closely associated with the accumulation of amyloid-beta (Aβ) peptides in brain. The enzyme β-secretase (BACE1), pivotal Aβ production, represents promising therapeutic target for AD. While bioactive derived from food protein hydrolysates have neuroprotective properties, their inhibitory effects on BACE1 remain largely unexplored. In this study, we evaluated potential gliadin, whey, and casein proteins prepared using bromelain, papain, thermolysin. Through vitro cellular assays, bromelain-hydrolyzed gliadin (G-Bro) emerged as most potent inhibitor, an IC

Язык: Английский

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Lactuca racemosa Willd., Source of Antioxidants with Diverse Chemical Structures

Molecules, Год журнала: 2024, Номер 29(24), С. 5975 - 5975

Опубликована: Дек. 18, 2024

Ethanolic extracts from the roots and aerial parts of hitherto chemically uninvestigated lettuce species Lactuca racemosa Willd. (Cichorieae, Asteraceae) were chromatographically separated to obtain eight sesquiterpenoids, two apocarotenoids (loliolide (6S,9S) roseoside), three phenolic glucosides (apigenin 7-O-glucoside, eugenyl-4-O-β-glucopyranoside, 5-methoxyeugenyl-4-O-β-glucopyranoside). Four isolated sesquiterpene lactones (8-α-angeloyloxyleucodin, matricarin, 15-deoxylactucin, deacetylmatricarin 8-β-glucopyranoside) have not previously been found either in spp. or Cicerbita In addition, HPLC-PAD chromatographic methods used estimate derivatives, luteolin caffeic acid derivatives contents analyzed plant material. The contained c. 3.0% dry weight chicoric equal amounts (0.4%) caftaric 7-O-glucoside. fewer metabolites but rich glucoside (c. 1.3%). aglycone most abundant lactone was evaluated with respect its neuroprotective effect H2O2- 6-OHDA-treated human neuroblastoma SH-SY5Y cells. This compound, at concentrations 10 50 μM, provided partial protection undifferentiated cells, a concentration it retinoic acid-differentiated cells H2O2-induced damage. model 6-OHDA-evoked cytotoxicity, sesquiterpenoid less effective. Our findings may support inclusion this into diet.

Язык: Английский

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Exploring Dietary Interventions in Autism Spectrum Disorder

Foods, Год журнала: 2024, Номер 13(18), С. 3010 - 3010

Опубликована: Сен. 23, 2024

Autism spectrum disorder (ASD) involves social communication difficulties and repetitive behaviors, it has a growing prevalence worldwide. Symptoms include cognitive impairments, gastrointestinal (GI) issues, feeding difficulties, psychological problems. A significant concern in ASD is food selectivity, leading to nutrient deficiencies. Common GI issues ASD, such as constipation irritable bowel syndrome, stem from abnormal gut flora immune system dysregulation. Sensory sensitivities behavioral challenges exacerbate these problems, correlating with neurological symptom severity. Children also exhibit higher oxidative stress due low antioxidant levels like glutathione. Therapeutic diets, including ketogenic, high-antioxidant, gluten-free casein-free, probiotic-rich show potential managing symptoms behavior, communication, stress, though the evidence limited. Various studies have focused on different populations, but there increasing about impact among children. This review aims highlight preferences of population, analyze effect physicochemical nutritional properties foods selectivity its consumption, deficiencies individuals evaluate effectiveness therapeutic diets rich antioxidants, ketogenic essential fatty acids, challenges.

Язык: Английский

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Luteolin, chemical feature and potential use for oral disease

Current Oral Health Reports, Год журнала: 2024, Номер 11(4), С. 290 - 296

Опубликована: Авг. 27, 2024

Язык: Английский

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