Environmental Contamination and Mining Impact: Physico-Chemical and Biological Characterization of Propolis as an Indicator of Pollution in the Roșia Montană Area, Romania
Plants,
Год журнала:
2025,
Номер
14(6), С. 866 - 866
Опубликована: Март 10, 2025
Contamination
with
heavy
metal
ions
from
mining
activities
presents
a
major
environmental
issue.
This
study
investigates
pollution
caused
by
metals
mining,
particular
emphasis
on
toxic
and
essential
for
living
organisms.
It
starts
analyzing
the
sources
of
its
effects
soil,
vegetation,
water,
wildlife
(propolis
produced
honey
bees
in
natural
environments).
Propolis
is
an
indicator
contamination
metals,
valuable
product
ecosystems.
As
part
investigation,
cations
(Pb2+,
Cu2+,
Cd2+,
Zn2+,
As3+,
Fe2+,
Sr2+)
cultivated
vegetables
(carrot,
turnip,
onion,
potato)
was
monitored
9
points
Roșia
Montană
area,
Romania,
as
well
river
that
runs
through
area.
The
maximum
values
parameters
investigated
were
recorded
soil
(108.32
mg/kg
Pb2+,
23.06
102.17
As3+),
water
(11.00
µg/L
903.47
60.13
1903.08
148.07
44,024.08
Fe2+),
(0.72
0.17
Cd2+)
it
followed
whether
same
are
found
propolis
(maximum
10.14
6.32
0.158
6.0
1.04
12.06
Sr2+).
analyzed
waters
pH,
sulfates,
oxygen
nutrient
regime,
microbial
load.
Additional
investigations
carried
out
into
quality
these
samples:
activity,
moisture,
hygroscopicity,
solubility,
volatile
oils,
oxidation
index,
measuring
point,
density,
dry
matter,
material
insoluble
ethanol,
extractable
ash,
wax.
highest
189.4
mg
GAE/g
phenols,
84.31
QE/g
flavonoids,
0.086
µg/mL
IC50
antioxidant
activity.
indicates
bee
products,
such
propolis,
can
be
areas.
Язык: Английский
Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review
Antioxidants,
Год журнала:
2025,
Номер
14(1), С. 81 - 81
Опубликована: Янв. 12, 2025
This
narrative
review
explores
the
potential
effects
of
Propolis
and
its
bioactive
compounds
on
bone
health.
Propolis,
a
resinous
product
collected
by
bees,
is
renowned
for
antimicrobial,
anti-inflammatory,
antioxidant
properties.
Recent
research
emphasizes
positive
role
in
osteogenesis,
primarily
through
modulation
osteoclast
osteoblast
activity
via
molecular
pathways.
Key
mechanisms
include
reducing
inflammatory
cytokines,
protecting
against
oxidative
stress,
upregulating
growth
factor
essential
formation.
While
such
as
Caffeic
Acid
Phenethyl
Ester,
Apigenin,
Quercetin,
Ferulic
have
been
well-documented,
emerging
evidence
points
to
significant
roles
less-studied
like
Pinocembrin,
Kaempferol,
p-Coumaric
acid,
Galangin.
synthesizes
current
literature,
focusing
which
these
influence
osteogenesis.
Firstly,
it
techniques
characterizing
presented
propolis,
chemogeographic
variations
composition,
both
crude
extracts
isolated
tissue,
offering
comprehensive
analysis
recent
findings
across
different
experimental
models.
Further,
discusses
In
summary,
modulate
signaling
pathways,
including
nuclear
kappa
beta,
wingless-related
integration
site,
mitogen-activated
protein
kinase,
vascular
endothelial
factor,
reactive
oxygen
species.
These
pathways
receptor
activator
kappa-β/receptor
kappa-β
ligand/osteoprotegerin
system,
fostering
cell
differentiation.
regulation
mitigates
excessive
formation,
stimulates
activity,
ultimately
contributes
restoration
homeostasis
maintaining
balanced
remodeling
process.
Язык: Английский
Therapeutic Potential of Propolis and Royal Jelly in Encephalitozoon Intestinalis Infection: An in Vitro Study
Acta Parasitologica,
Год журнала:
2025,
Номер
70(1)
Опубликована: Янв. 24, 2025
Abstract
Purpose
Encephalitozoon
intestinalis
is
an
obligate
intracellular
microsporidian
fungus
that
causes
severe
gastrointestinal
infections,
particularly
in
immunocompromised
individuals.
Propolis
(PROP),
a
resinous
substance
derived
from
bees,
has
antimicrobial,
anti-inflammatory
and
antioxidant
properties,
while
royal
jelly
(RJ)
immunomodulatory,
antimicrobial
activities.
The
aim
of
this
study
was
to
investigate
the
therapeutic
potential
PROP
RJ
against
E.
intestinalis.
Methods
phenolic
composition
analysed
by
high-performance
liquid
chromatography
with
diode
array
detection,
chemical
components
were
evaluated
according
ISO12824
standards.
cytotoxicity
on
HEK-293
cells
using
XTT
assay.
three
highest
non-cytotoxic
concentrations
each
sample
tested
for
their
effects
spores
qRT-PCR.
Trichrome-stained
photomicrographs
used
assess
spore
density
treated
RJ.
Results
analysis
revealed
flavonoids
such
as
quercetin,
kaempferol,
pinocembrin
galangin,
well
acids
caffeic
cinnamic
acids,
known
bioactive
properties.
contained
mainly
proteins,
lipids,
carbohydrates
sugars,
reflecting
its
role
nutritionally
biologically
active
substance.
According
results
first
evaluating
effect
intestinalis,
all
showed
significant
inhibitory
growth
compared
control
group.
Conclusion
In
conclusion,
we
believe
should
be
considered
alternative
option
development
antimicrosporidial
drugs
due
medicinal
pharmaceutical
Язык: Английский
Linoleic Fatty Acid from Rwandan Propolis: A Potential Antimicrobial Agent Against Cutibacterium acnes
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(3), С. 162 - 162
Опубликована: Фев. 27, 2025
Acne
is
a
very
common
skin
condition
that
causes
pimples
in
80%
of
adolescents
despite
the
many
effective
treatments
developed.
Various
compounds
have
been
employed
treatment
acne,
including
erythromycin
ointments
and
antiseptics,
yielding
mixed
results.
The
rise
erythromycin-resistant
C.
acnes
strains
has
driven
pursuit
new
antimicrobial
agents,
especially
those
obtained
from
natural
sources.
Propolis
was
collected
Rwanda
extracted,
fractioned,
analyzed
for
its
activity
against
growth
accordance
with
NCLSI
guidelines.
Our
work
revealed
linoleic
acid
significant
effect
on
at
low
concentration
(16
µg/mL).
A
comparison
activities
broad
panel
well-known
fatty
acids
specific
mode
action
acid,
characterized
by
membranotropic
Bacillus
cereus
established
measuring
extracellular
ATP
levels
as
an
indicator
membrane
permeability.
data
suggest
could
be
promising
candidate
developing
propolis-based
ointment
acne
treatment.
Язык: Английский
Propolis extract attenuates cisplatin-induced nephrotoxicity in female rats and their offspring
Abd El-Fattah B. M. El-Beltagy,
Gamal Mohamed,
Lashin Saad Ali
и другие.
Egyptian Journal of Basic and Applied Sciences,
Год журнала:
2024,
Номер
12(1), С. 1 - 21
Опубликована: Дек. 29, 2024
Cisplatin
is
used
to
treat
a
variety
of
solid
tumors,
including
those
the
head,
neck,
breast,
testis,
and
ovary.
Clinically,
nephrotoxicity
can
occur
in
20%
35%
cisplatin-receiving
patients.
Research
has
demonstrated
that
levels
cisplatin
maternal
blood
umbilical
cord
are
approximately
same.
Propolis
produced
by
bees
antioxidant
anti-inflammatory
properties.
Therefore,
this
study
aims
evaluate
potential
therapeutic
role
propolis
extract
(PE)
against
cisplatin-induced
female
rats
their
pups.
Thirty-two
pregnant
were
divided
into
four
groups:
control,
PE,
cisplatin-treated,
+
PE
groups.
was
injected
at
gestation
days
7
14,
followed
treatment
with
from
gestational
day
20
until
end
weaning.
The
samples
collected,
kidneys
removed
mother's
rat
Supplementation
cisplatin-given
mothers
fetuses
showed
remarkable
reduction
oxidative
stress,
inflammation,
disrupted
renal
functions
induced
cisplatin.
This
manifested
significant
decline
elevated
serum
malondialdehyde
(MDA),
tumor
necrosis
factor-α
(TNF-α),
cystatin-C
levels,
urea,
creatinine,
uric
acid,
rise
superoxide
dismutase
(SOD)
catalase
(CAT),
glutathione
peroxidase
(GPx).
associated
restoration
kidney
histopathological
alterations
Additionally,
suppressed
caspase-3,
up-regulated
proliferating
cell
nuclear
antigen
(PCNA)
activities
tissues.
attenuated
through
combating
stress
pathophysiological
changes
Язык: Английский
Propolis in Dental Implantology: A Systematic Review of Its Effects and Benefits
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(11), С. 339 - 339
Опубликована: Ноя. 12, 2024
Dental
implants
are
widely
recognized
for
their
effectiveness
in
restoring
missing
teeth,
yet
success
is
often
compromised
by
infections
or
inadequate
osseointegration.
Propolis,
a
natural
resinous
substance
with
potent
antimicrobial,
anti-inflammatory,
and
osteogenic
properties,
has
emerged
as
promising
adjunct
dental
implantology.
This
systematic
review
critically
evaluates
the
current
evidence
on
incorporation
of
propolis
into
implants,
focusing
its
impact
antimicrobial
efficacy,
bone
healing,
overall
implant
stability.
The
study
protocol
was
registered
PROSPERO
under
registration
number
CRD42024577122.
PRISMA
diagram
visually
represented
search
strategy,
screening,
inclusion
process.
Two
reviewers
conducted
comprehensive
literature
across
five
databases:
PubMed,
PubMed
Central,
Embase,
Scopus,
Web
Science.
synthesized
findings
from
13
studies;
vitro,
vivo,
clinical
studies,
highlighting
that
significantly
enhances
antibacterial
antifungal
activities
against
pathogens
such
Staphylococcus
aureus,
Candida
albicans,
Streptococcus
mutans,
thereby
reducing
risk
peri-implant
infections.
Additionally,
promotes
osseointegration
stimulating
osteoblast
activity
inflammatory
cytokine
expression,
leading
to
improved
formation
anti-inflammatory
antioxidant
properties
further
contribute
favorable
healing
environment,
enhancing
long-term
implants.
underscores
potential
safe,
biocompatible,
effective
material
improving
outcomes.
However,
it
also
identifies
need
more
extensive
trials
fully
establish
standardized
protocols
application
provides
an
overview
propolis’s
role
suggests
avenues
future
research
optimize
benefits
practice.
Язык: Английский
Propolis Extract: Weaving Antioxidant Power into Polymeric Composites Through Electrospinning
Polymers,
Год журнала:
2024,
Номер
16(22), С. 3230 - 3230
Опубликована: Ноя. 20, 2024
The
manufacture
of
composites
with
bioactive
compounds
represents
a
promising
strategy
for
developing
advanced
materials
in
biomedical,
food,
and
industrial
applications.
However,
challenges
such
as
stability,
bioactivity
retention,
controlled
release
hinder
their
effectiveness.
Electrospinning
emerges
viable
technique
encapsulating
compounds,
offering
advantages
high
surface
area,
porosity,
gradual
release,
which
are
critical
maintaining
the
embedded
compounds.
Regarding
composition,
propolis
has
been
highlighted
potential
source
great
biopolymer
ingredient
due
to
its
antioxidant
antimicrobial
properties.
This
study
analyzed
composition
activity
three
commercial
extracts
select
most
suitable
extract
fiber
composite
production
using
zein
polyethylene
oxide
(PEO),
both
recognized
safe.
characterization
electrospun
fibers,
including
morphology,
thermal
properties,
was
conducted
through
various
analytical
techniques.
findings
highlight
effectiveness
electrospinning
paving
way
innovations
technologies
across
multiple
sectors.
Язык: Английский