Unlocking the potential of photobiomodulation therapy for brain neurovascular coupling: The biological effects and medical applications
Journal of Cerebral Blood Flow & Metabolism,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Photobiomodulation
(PBM)
therapy
stands
as
an
innovative
neurostimulation
modality
that
has
demonstrated
both
efficacy
and
safety
in
improving
brain
function.
This
exerts
multifaceted
influences
on
neurons,
blood
vessels,
their
intricate
interplay
known
neurovascular
coupling
(NVC).
Growing
evidence
indicates
NVC
may
present
a
promising
target
for
PBM
intervention.
However,
the
detailed
mechanisms
underlying
its
therapeutic
benefits
remain
to
be
fully
understood.
review
aims
elucidate
potential
metabolic
pathways
signaling
cascades
involved
modulatory
effects
of
PBM,
while
also
exploring
extensive
repertoire
applications
neurologic
psychiatric
conditions.
The
prospects
within
realm
investigation
are
intensively
considered,
providing
deeper
insights
into
powerful
capabilities
revolutionize
treatments.
Язык: Английский
Exploring the Role of Neuromodulation in Neurodegenerative Disorders: Insights from Alzheimer's Disease and Parkinson's Disease
Brain Disorders,
Год журнала:
2025,
Номер
unknown, С. 100187 - 100187
Опубликована: Фев. 1, 2025
Язык: Английский
Dose-dependent effects of transcranial photobiomodulation on brain temperature in patients with major depressive disorder: a spectroscopy study
Lasers in Medical Science,
Год журнала:
2024,
Номер
39(1)
Опубликована: Окт. 7, 2024
Язык: Английский
Mourning for Silence: Bereavement and Tinnitus—A Perspective
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(7), С. 2218 - 2218
Опубликована: Март 25, 2025
Tinnitus
is
defined
as
the
conscious
awareness
of
a
tonal
or
composite
noise
for
which
there
no
identifiable
corresponding
external
acoustic
source,
becomes
tinnitus
disorder
when
phantom
sound
associated
with
suffering
and/or
disability.
There
only
limited
knowledge
about
time
course
disorder.
Bereavement
science
has
identified
four
different
trajectories:
resilience,
recovery,
chronic,
and
delayed.
The
question
arises
whether
these
trajectories
exist
in
well
if
one
considers
loss
silence
(at
will).
To
verify
exist,
short-term
progression
was
analyzed
retrospectively
using
an
Ecological
Momentary
Assessment
(EMA)
approach,
extracting
data
from
patients
who
started
TrackYourTinnitus
(TYT)
app
(version
1,
Ulm
University,
2013)
start
their
perception.
Four
were
via
TYT
acute
tinnitus,
bereavement
reconstructed
based
on
EMA.
In
conclusion,
this
perspective
suggests
that
known
may
prospective
evaluations
larger
samples
are
warranted
to
confirm
disprove
analogy
between
conceived
(controllable)
silence.
Язык: Английский
Repetitive Transcranial Photobiomodulation Improves Working Memory and Attention in Adults with ADHD: A 4-Week Follow-Up Study
Photobiomodulation Photomedicine and Laser Surgery,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 16, 2025
Background:
Working
memory
(WM)
impairments
and
inattention
symptoms
are
prevalent
among
adults
with
attention-deficit/hyperactivity
disorder
(ADHD).
Transcranial
photobiomodulation
(tPBM)
is
a
promising
brain
stimulation
technique
that
may
enhance
cognitive
function
ADHD.
Objectives:
We
aimed
to
explore
the
effects
of
tPBM
on
improving
N-back
WM
Continuous
Performance
Test-Identical
Pairs
(CPT-IP)
attention
tasks
in
ADHD,
as
well
its
baseline
predictive
factors.
Methods:
Forty-eight
ADHD
underwent
7-day
intervention
(720
s
daily,
1064-nm
wavelength,
250
mW/cm2
irradiance).
Participants
completed
(1-back,
2-back,
3-back)
WM,
CPT-IP
(cpt-2,
cpt-3,
cpt-4)
at
(T1),
after
first
(T2),
seventh
(T3)
interventions,
during
four
weekly
follow-ups
(T4-T7).
Safety
was
assessed
using
Treatment
Emergent
Symptom
Scale
(TESS).
Results:
The
participants
showed
significant
improvements
3-back,
cpt-4
(all
p
<
0.001),
peak
effect
sizes
observed
2-3
weeks
post-intervention
(Cohen's
d
=
0.84-1.26).
Lower
performance
predicted
greater
improvement.
well-tolerated;
three
(6.3%)
reported
mild
adverse
events
(TESS
scores
≤2),
all
which
resolved
spontaneously.
Conclusions:
effective
well-tolerated
for
suggesting
potential
use
non-pharmacological
approach
management.
Язык: Английский
Neurometabolite Changes After Transcranial Photobiomodulation in Major Depressive Disorder: A Randomized Controlled Trial Investigating Dose-Dependent Effects
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(10), С. 3402 - 3402
Опубликована: Май 13, 2025
Background:
Transcranial
photobiomodulation
(t-PBM)
is
a
promising
non-invasive
therapy
for
Major
Depressive
Disorder
(MDD).
MDD
associated
with
altered
brain
metabolism,
including
changes
in
N-acetylaspartate
(NAA),
choline
(Cho),
and
creatine
(Cr).
This
study
assessed
the
effects
of
varying
t-PBM
doses
on
neurometabolite
levels
dorsolateral
prefrontal
cortex
(dlPFC)
their
correlations
clinical
outcomes.
Methods:
In
this
randomized,
sham-controlled,
cross-over
study,
33
adults
received
one
session
at
low,
medium,
high
sham
treatment.
Proton
magnetic
resonance
spectroscopy
(1H-MRS)
measured
NAA,
Cho,
Cr
pre-
post-treatment.
Clinical
outcomes
were
using
Montgomery-Åsberg
Depression
Rating
Scale
(MADRS)
Symptoms
Questionnaire
(SDQ).
Statistical
analyses
included
paired
t-tests
or
Wilcoxon
signed-rank
tests
changes,
linear
mixed-effects
regression
models
dose,
neurometabolites,
time
effects.
Results:
NAA
increased
significantly
(7.52
±
0.777
to
8.12
1.05
mmol/L
session;
7.36
0.85
7.85
0.68
across
all
sessions);
however,
these
not
specific
sham.
No
significant
observed
Cho
levels.
Positive
found
between
MADRS
scores
(r
=
0.59,
p
0.017),
negative
SDQ
medium
dose
-0.91,
0.011).
Conclusions:
While
increased,
neurometabolites
observed,
findings
do
suggest
effect
t-PBM.
Larger
randomized
controlled
trials
optimized
dosing
protocols,
extended
follow-up,
advanced
are
needed
clarify
neurometabolic
therapeutic
potential
MDD.
Язык: Английский
Dose-dependent tolerability and safety of transcranial photobiomodulation: a randomized controlled trial
Lasers in Medical Science,
Год журнала:
2025,
Номер
40(1)
Опубликована: Май 29, 2025
Язык: Английский
A Grant Report: Examining the Efficacy of Remote Photobiomodulation Therapy in Adolescents with Major Depressive Disorder
Photonics,
Год журнала:
2024,
Номер
11(9), С. 839 - 839
Опубликована: Сен. 5, 2024
Major
depressive
disorder
(MDD)
is
a
prevalent
mental
health
condition
affecting
significant
portion
of
the
population
worldwide.
This
can
impact
individuals
all
ages,
including
adolescents,
leading
to
an
on
various
aspects
their
lives.
Adolescence
crucial
phase
human
development,
characterized
by
several
neurobiological
changes.
The
onset
MDD
during
this
period
result
in
damage
not
only
teenagers
but
also
might
have
long-lasting
implications
for
future
as
adults.
Notably,
adolescents
often
associated
with
biomarkers,
such
increased
levels
inflammatory
cytokines
(e.g.,
IL-6,
TNF-α),
oxidative
stress
markers,
and
alterations
neurotransmitter
levels,
indicating
complex
interplay
biological
factors.
Therefore,
early
intervention
essential
addressing
phase.
Photobiomodulation
therapy
(PBMT)
emerges
innovative
promising
approach
that
utilizes
light,
especially
near-infrared
(NIR)
red
spectra,
trigger
therapeutic
effects.
targeting
skull
abdomen
PBMT
explore
bidirectional
communication
between
intestinal
system
central
nervous
remote
and/or
systemic
way.
In
context,
we
present
rationale
design
ongoing
study
aiming
assess
efficacy
symptoms
biomarkers
mitochondrial
function
MDD.
Язык: Английский