Viral-bacterial pneumonia in COVID-19: clinical and laboratory characteristics of patients and a spectrum of bacterial pathogens

Health and Ecology Issues, Год журнала: 2023, Номер 20(2), С. 27 - 34

Опубликована: Июль 10, 2023

Objective. To study the clinical and laboratory data of patients with viral-bacterial pneumonia caused by SARS-CoV-2, to evaluate spectrum bacterial causative agents their sensitivity antibacterial drugs. Materials methods . 50 cases associated COVID-19 infection were analyzed. The gender-age structure patients, data, degree disease severity concomitant diseases studied. Microbiological examination sputum bronchoalveolar lavage (BAL) was performed bacteriological method using an automatic microbiological analyzer. Identification selected cultures determination drugs provided. Results average age in studied group 71,1 ± 14,8 years. 90% had diseases, mainly cardiovascular system. secondary diagnosed on 13,0 5,0 day from onset characterized bilateral lung lesions. most common etiological factors microorganisms Enterobacteriaceae family — 37%, Staphylococcus aureus 23% Acinetobacter baumannii 13%. isolated strains drug resistance aminopenicillins, cephalosporins, fluoroquinolones, aminoglycosides carbapenems. Conclusion high level SARS-CoV-2 antimicrobial requires wider use reserve implementation other treatment strategies.

Язык: Английский

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The Rapidly Changing Patterns in Bacterial Co-Infections Reveal Peaks in Limited Gram Negatives during COVID-19 and Their Sharp Drop Post-Vaccination, Implying Potential Evolution of Co-Protection during Vaccine–Virus–Bacterial Interplay

Viruses, Год журнала: 2024, Номер 16(2), С. 227 - 227

Опубликована: Янв. 31, 2024

SARS-CoV-2 has caused the most devastating pandemic of all time in recent human history. However, there is a serious paucity high-quality data on aggravating factors and mechanisms co-infection. This study aimed to identify trending patterns bacterial co-infections types associated outcomes three phases pandemic. Using quality hospital data, we have investigated fatality rates, profiles, before, during, after COVID-19 vaccination. Out 389 isolates used different aspects, 298 were examined before during (n = 149 n during). In this group, death rates 32% compared only 7.4% with significant association (p-value 0.000000075). rate was 34% co-infected 170) non-co-infected patients 128), indicating highly value 0.00000000000088). analysis without other respiratory problems 28) indicated that among remaining 270 patients, occurred 30% 150) 0.8% 120) high p-value 0.00000000076. The vaccination showed decline Staphylococcus aureus concomitant peaks Gram negatives before/n including Klebsiella pneumonian 11/49 before/during, E. coli 10/24, A. baumannii 8/25, Ps. aeruginosa 5/16, S. 13/1. Nevertheless, post-vaccination phase 91), gender-specific for potential differences susceptibility. Methicillin-resistant dominated both genders followed by males females, latter gender showing higher isolations species. pneumoniae declined third place male patients. drastic K. strongly implied co-protection vaccines. Future would gain more insights into molecular mimicry.

Язык: Английский

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Impact of nosocomial infections in patients with diabetes mellitus and SARS-CoV-2 in a respiratory care unit

Revista Médica Del Hospital General De México, Год журнала: 2024, Номер 87(1)

Опубликована: Фев. 21, 2024

Background:In Mexico, 29% of mortality resulting from SARS-CoV-2 was associated with one or more comorbidities.Diabetes mellitus the most frequently increasing in-hospital mortality.Objective: This study aimed at determining impact nosocomial infections in diabetic patients diagnosed COVID-19.Materials and methods: An analysis 930 performed, grouping data April 2020 to December 2021.Survival, hospital stay, causative agents, antimicrobial resistance, comorbidities were variables interest.Results: About 30% had diabetes mellitus, which presented a greater number concomitant such as arterial hypertension 50%, chronic kidney disease 13%.The survival function higher without mellitus.Conclusions: The association between increased length stay mortality, is why multidisciplinary teams are important carry out prevention programs establish sanitation measures.

Язык: Английский

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Narrative Review of Factors Associated With SARS-CoV-2 Coinfection in Middle Eastern Countries and the Need to Vaccinate Against Preventable Disease

Journal of Infection and Public Health, Год журнала: 2024, Номер 18(1), С. 102600 - 102600

Опубликована: Ноя. 26, 2024

Язык: Английский

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Predictive role of culture-based MIC testing vs. genotyping for carbapenem-resistant Enterobacterales in a non-universal screening, highly resourced setting

Electronic Journal of General Medicine, Год журнала: 2023, Номер 20(4), С. em495 - em495

Опубликована: Апрель 12, 2023

A lack of evidence accuracy for various testing modalities carbapenem-resistant Enterobacterales (CRE) reduces the efficiency screening and delays isolation carriers. This study examined performance phenotypic detection CRE in comparison to molecular testing. cross-sectional was conducted an academic medical institution Saudi Arabia on CRE-screened patients during a 36-month period (April 1, 2019, through March 31, 2022). Cases were followed up their susceptibility status by gradient method genotypes. Of 3,116 samples tested, 359 carbapenemase genes detected 297 strains (9.5%) belonging 292 patients. Oxacilliniase-48 (OXA-48) most frequently genotype (n=190, 64%), combined New Delhi metallo-B-lactamase (NDM)/OXA-48 (n=77, 25.9%). Variable missed days encountered genotypes (0-18.5 days), with excellent clinical utility index obtained OXA-48 phenotypically. The data provided some insights into predictive role shortcomings e-test alone screening. While it reasonable approach population dominated genotypes, more likely miss NDM-incurred carbapenemase. Thus, local epidemiology must be considered when designing protocol addition consideration cost turnaround time.

Язык: Английский

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Synthesis, Antimicrobial Activity and Dual Target Docking Studies of Novel 1-(5-Chloro-1-benzofuran-2-yl)-3-substituted Phenyl Prop-2-en-1-ones

Asian Journal of Chemistry, Год журнала: 2023, Номер 35(12), С. 2979 - 2986

Опубликована: Дек. 2, 2023

This study involved synthesizing five novel derivatives of 1-(5-chloro-1-benzofuran-2-yl)-3-substituted phenyl prop-2-en-1-ones throughthe Claisen-Schmidt condensation reaction, using 5-chloro-2-acetyl benzofuran and aromatic aldehydes in the presence base catalyst. The chemical structures these compounds were confirmed by IR spectroscopy, 1H NMR spectroscopy mass spectrometry. Schrödinger docking simulations employed to ascertain binding affinity synthesized Mycobacterium tuberculosis enoyl-ACP reductase Escherichia coli Topoisomerase IV. Subsequently, anti-tubercular vitro antibacterial activities also investigated. Anti-tubercular efficacy was determined MABA method, while effectiveness assessed against both Gram-positive Gram-negative bacterial strains through agar cup plate. findings from assays provide insights into potential as agents possessing characteristics, thereby offering promising prospects for further investigation field drug development.

Язык: Английский

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Critically ill children with SARS-COV-2 Omicron infection at a national children medical center, Guangdong, China

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Дек. 21, 2023

Abstract Background SARS-CoV-2 infection is described as asymptomatic, mild, or moderate disease in most children. related death children and adolescents rare according to the current reports. COVID-19 cases increased significantly China during Omicron surge, clinical data regarding pediatric critical patients infected with omicron variant limited. In this study, we aim provide an overview of characteristics outcomes admitted Pediatric Intensive Care Unit (PICU) at a national children's medical center Guangdong Province, China, outbreak infection. Methods We conducted retrospective study from November 25, 2022, February 8, 2023, which included 63 critically ill children, under age 18, diagnosed The were referred institutions province. records these carefully analyzed summarized. Results During period, included. median was 2 years (IQR: 1.0–8.0), sex-ratio (male/female) 1.52. Twelve (age ≥ 3 years) vaccinated. length hospital stay 14 days 6.5–23) duration fever 5 3-8.5). 30 had clear contact history family members who SARS-CoV-2. Three tested positive for did not show any abnormalities on chest imaging examination. Out total patients, 33 bacterial co-infection, Staphylococcus aureus being commonly detected pathogen. Our cohort exhibited respiratory nervous system involvement primary features. Furthermore, 50 required mechanical ventilation, 7 (IQR 3.75–13.0). Among 35 developed failure, 16 experienced deteriorating progression symptoms ultimately succumbed illness, multiple organ failure attributed cause death. Conclusion present case series variant. While there evidence suggesting that may less severe symptoms, it important continue striving measures can minimize pathogenic impact

Язык: Английский

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