Recent perspectives in clinical development of malaria vaccines

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 15, 2025

---

Zika Virus in Malaria-Endemic Populations: A Climate Change-Driven Syndemic in the Sudan Savannah, Nigeria

Microbiology Research, Год журнала: 2025, Номер 16(6), С. 109 - 109

Опубликована: Май 27, 2025

Zika and malaria are important vector-borne febrile illnesses in humans. In this study, we determined the circulation of virus infections, their hotspots, predominant clinical features. A cross-sectional study was carried out six Local Government Areas (LGAs) Kaduna State, Nigeria, from September 2018 to May 2019. Four hundred twenty sera were screened for (ZV) IgM IgG, Plasmodium falciparum antigen using ELISA immunochromatographic test, respectively. Overall, a seroprevalence 14.5% found Zika, 9.3% malaria. Nineteen (4.5%) thirty-five (8.3%) patients seropositive ZV Co-infection rates (ZV IgM) (0.5%: 2/420), IgG (0.7%: 3/420) observed. Lere (10%: 7/70 IgM), Kachia (14.3%: 10/70 IgG) Zaria (18.6%: 13/70 malaria) LGAs identified as hotspots Age significantly associated with (p = 0.008) 0.004). Patients aged 1–10 years had highest (18.4%), while those 21–30 prevalence (6.1%: 7/114). Out pregnant (56/420) tested, 5.37% (3/56) antibodies both recent past infection. significant association between maculopapular rash 0.021) well duration fever infection 0.041). We highlight that is endemic silently circulating, providing baseline data further molecular epidemiological studies.

Язык: Английский

---

Ring hemorrhages in the central nervous system of severely anemic cynomolgus monkeys

Veterinary Pathology, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

Ring hemorrhages are characteristic ring-shaped lesions in the parenchyma of central nervous system (CNS) surrounding small blood vessels and typically reported to occur white matter brain. In humans, they seen various diseases, including pernicious anemia, cerebral fat embolism, malaria. also sporadically CNS animals have been previously 4 nonhuman primate (NHP) species with forms anemia. Here we present results preclinical toxicity studies testing drug candidates different modalities, targets, mechanisms action, indications NHPs (cynomolgus monkeys). Within each study, ring were observed associated severe anemia affected line those reported. They occurred gray occasionally brain spinal cord; brain, thalamus, basal ganglia, cerebellum particularly affected. Lesions comprised a eosinophilic core, sometimes or slightly basophilic amorphous material center, surrounded by red cells and/or microglial microglia aggregates. Fibrin staining confirmed presence fibrin core. No commonality type/cause was noted; one considered spontaneous (non-treatment-related) finding. A thorough examination is therefore recommended anemic conditions animals. Pathologists should be aware this finding its relationship when assessing associations diseases candidates.

Язык: Английский

---

Challenges and Strategies in Administering Anesthesia to Pregnant Patients With Malaria: A Comprehensive Review

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Авг. 20, 2024

Malaria remains a significant global health challenge, particularly in sub-Saharan Africa, where its impact on pregnant women and their fetuses is profound. The disease's complex interaction with pregnancy introduces unique challenges anesthesia management, necessitating thorough understanding of both malaria implications for anesthetic care. This review aims to explore the multifaceted issues associated patients malaria, examining disease specific considerations required effective management. A comprehensive current literature was conducted, focusing physiological effects pregnancy, complications, related challenges. synthesizes findings from clinical studies, case reports, expert guidelines provide an overview best practices strategies. can lead severe complications such as maternal anemia, placental insufficiency, preterm labor, all which complicate identifies key anesthesia, including choice techniques, drug interactions, fluid Specific include managing ensuring adequate hemodynamic stability, mitigating potential risks medications. Effective management requires nuanced approach that addresses changes pregnancy. underscores need tailored strategies highlights areas further research enhance patient safety outcomes. Recommendations are provided guide clinicians optimizing care this vulnerable population.

Язык: Английский

---

Plasmodium SEY1 is a novel druggable target that contributes to imidazolopiperazine mechanism of action

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

The precise mode of action ganaplacide (KAF156), a phase III antimalarial candidate, remains elusive. Here we employ omics-based methods with the closely related chemical analog, GNF179, to search for potential Plasmodium targets. Ranking targets derived from genetics and proteomic affinity chromatography methodologies identifies SEY1, or Synthetic Enhancement YOP1, which is predicted encode an essential dynamin-like GTPase implicated in homotypic fusion endoplasmic reticulum (ER) membranes. We demonstrate that GNF179 decreases SEY1 melting temperature. further show binds recombinant subsequently inhibits its activity, required maintaining ER architecture. Using ultrastructure expansion microscopy, find treatment changes parasite Golgi morphology. also confirm SEY1 gene P. falciparum. These data suggest may contribute mechanism imidazolopiperazines new attractive druggable target.

Язык: Английский

---