Antibacterial Crosslinker for Ternary PCL-Reinforced Hydrogels Based on Chitosan, Polyvinyl Alcohol, and Gelatin for Tissue Engineering DOI Open Access

Karina Del Ángel-Sánchez,

Ana Victoria Treviño-Pacheco,

Imperio Anel Perales-Martínez

и другие.

Polymers, Год журнала: 2025, Номер 17(11), С. 1520 - 1520

Опубликована: Май 29, 2025

Current hydrogels used for cartilage tissue engineering often lack the mechanical strength and structural integrity required to mimic native human cartilage. This study addresses this limitation by developing reinforced based on a ternary polymer blend of poly(vinyl) alcohol (PVA), gelatin (GL), chitosan (CH), with gentamicin sulfate (GS) as an antimicrobial agent crosslinker. The were produced using two crosslinking methods, freeze/thaw heated cycles, forcespun polycaprolactone (PCL) nanofiber improve performance. Chemical characterization revealed that GS forms weak hydrogen bonds polymers, leading esterification PVA, covalent are formed result free amino group (-NH2) reacts carboxylic acid (-COOH) gelatin. SEM images help us see how fibers via force spinning technology, while properties evaluated uniaxial tensile compressive tests. Water retention measurements performed examine process’s influence hydrogel’s water retention, hydrogel surface roughness was obtained confocal microscopy images. A constitutive model non-Gaussian strain energy density introduced predict experimental behavior data hydrogel, considering non-monotonous softening function. Loading unloading tests demonstrated enhanced without compromising or biocompatibility because reaction between CH PCL-reinforced PVA/GL/CH shows strong potential repair applications.

Язык: Английский

Revolutionizing Food Packaging with Biobased Polymers, Active and Intelligent Materials for Enhanced Food Safety and Sustainability: Review DOI
Aminu Abdullahi, Tarangini Korumilli, K. Jagajjanani Rao

и другие.

Food and Bioprocess Technology, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

Язык: Английский

Процитировано

0

Injectable Biopolymer-Based Hydrogels: A Next-Generation Platform for Minimally Invasive Therapeutics DOI Creative Commons
Nargish Parvin, Sang Woo Joo, Tapas Kumar Mandal

и другие.

Gels, Год журнала: 2025, Номер 11(6), С. 383 - 383

Опубликована: Май 23, 2025

Injectable biopolymer-based hydrogels have emerged as a powerful class of biomaterials designed for minimally invasive therapeutic strategies in modern medicine. These smart hydrogels, derived from natural biopolymers, such alginate, chitosan, gelatin, hyaluronic acid, and collagen, offer unique advantages, including biocompatibility, biodegradability, the ability to mimic extracellular matrix. This review provides comprehensive overview recent advancements design, crosslinking mechanisms, biofunctionality injectable tailored targeted drug delivery tissue regeneration. Special attention is given their role situ gelling systems, cancer therapy, musculoskeletal repair, neural Challenges related mechanical strength, degradation control, clinical translation are also discussed, along with future perspectives scalable manufacturing regulatory approval.

Язык: Английский

Процитировано

0

Gel-Based Approaches to Vegan Leather: Opportunities and Challenges in Mimicking Leather Properties DOI Creative Commons
Soon Mo Choi, Do Hyun Lee,

Sun Mi Zo

и другие.

Gels, Год журнала: 2025, Номер 11(6), С. 395 - 395

Опубликована: Май 27, 2025

Recently, increased global awareness of environmental sustainability and ethical consumerism has amplified the demand for sustainable alternatives to animal-derived leather. Traditional leather manufacturing faces significant ecological challenges, including greenhouse gas emissions, excessive water consumption, deforestation, toxic chemical usage. Vegan emerged as a promising solution, predominantly fabricated from petroleum-based synthetic materials such polyurethane (PU) polyvinyl chloride (PVC). However, these have limitations due their non-biodegradability associated burdens. To overcome issues, this review critically explores feasibility developing vegan using gel-based derived natural polymers. These offer precise structural controllability, excellent biodegradability, potential significantly improved mechanical performance through hybridization nanocomposite strategies. Despite attributes, face limitations, insufficient tensile strength, poor abrasion resistance, susceptibility swelling, limited long-term stability, challenges in scaling up industrial production. This paper outlines physical properties required viable substitutes, reviews opportunities provided by materials, addresses technical proposes comprehensive strategies enhancing sustainable, eco-friendly production processes. Future research directions emphasize hybrid composite development, nanoparticle integration, circular processes, multi-disciplinary collaboration establish viable, market-competitive alternative conventional animal

Язык: Английский

Процитировано

0

Cellulose nanocrystal-based intelligent hydrogels: Innovations, challenges, and prospective application in advanced wound healing DOI
Santiago Martín, Lu Gan, Lingli Zhang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 316, С. 144752 - 144752

Опубликована: Май 27, 2025

Язык: Английский

Процитировано

0

Antibacterial Crosslinker for Ternary PCL-Reinforced Hydrogels Based on Chitosan, Polyvinyl Alcohol, and Gelatin for Tissue Engineering DOI Open Access

Karina Del Ángel-Sánchez,

Ana Victoria Treviño-Pacheco,

Imperio Anel Perales-Martínez

и другие.

Polymers, Год журнала: 2025, Номер 17(11), С. 1520 - 1520

Опубликована: Май 29, 2025

Current hydrogels used for cartilage tissue engineering often lack the mechanical strength and structural integrity required to mimic native human cartilage. This study addresses this limitation by developing reinforced based on a ternary polymer blend of poly(vinyl) alcohol (PVA), gelatin (GL), chitosan (CH), with gentamicin sulfate (GS) as an antimicrobial agent crosslinker. The were produced using two crosslinking methods, freeze/thaw heated cycles, forcespun polycaprolactone (PCL) nanofiber improve performance. Chemical characterization revealed that GS forms weak hydrogen bonds polymers, leading esterification PVA, covalent are formed result free amino group (-NH2) reacts carboxylic acid (-COOH) gelatin. SEM images help us see how fibers via force spinning technology, while properties evaluated uniaxial tensile compressive tests. Water retention measurements performed examine process’s influence hydrogel’s water retention, hydrogel surface roughness was obtained confocal microscopy images. A constitutive model non-Gaussian strain energy density introduced predict experimental behavior data hydrogel, considering non-monotonous softening function. Loading unloading tests demonstrated enhanced without compromising or biocompatibility because reaction between CH PCL-reinforced PVA/GL/CH shows strong potential repair applications.

Язык: Английский

Процитировано

0