Investigation on Cytotoxicity Against Lung Carcinoma Cell Line at New Metallacyclic Complexes of Titanium(IV) Incorporated With β‐Diketone and 4‐(1,4,5‐Triphenyl‐1H‐Imidazol‐2‐Yl) Benzene‐1,2‐Diol Derivatives DOI
Sathish Thanigachalam, Mahabarathi Subramaniyan, Shivabasayya V. Salimath

и другие.

Applied Organometallic Chemistry, Год журнала: 2025, Номер 39(6)

Опубликована: Май 25, 2025

ABSTRACT A series of eight heteroleptic derivatives titanium(IV) has been synthesized and characterized systematically employing physico‐chemical methods. Derivatives Ti 1 [(C 37 H 32 N 2 O 6 )Ti], 38 34 3 31 FN 4 ClN 5 BrN 8 7 F )Ti] were developed by refluxing an anhydrous benzene solution Ti(OPr i ) , acetylacetone, appropriate bidentate ligands (L ‑L in 1:2:1 stoichiometry. The electronic structure properties complexes (Ti ‑Ti studied density functional theory (DFT). UV–Visible method was used to determine the stability at periodic intervals. Binding interactions bovine serum albumin (BSA) calf thymus DNA (CT‐DNA) with corresponding assessed spectroscopic techniques such as absorption, fluorescence, circular dichroism have established intercalation static quenching for BSA effective manner. docking investigations also revealed that ‐Ti are well engaged via intercalative mode favorably occupy active site protein through hydrogen bonding. Furthermore, cytotoxicity against A549 (lung carcinoma) cell lines MTT (methylthiazolyldiphenyl‐tetrazolium) assay, IC 50 values found be range from 16.77 75.60 μM. displayed significant apoptosis induced cycle arrest G phase line.

Язык: Английский

Investigation on Cytotoxicity Against Lung Carcinoma Cell Line at New Metallacyclic Complexes of Titanium(IV) Incorporated With β‐Diketone and 4‐(1,4,5‐Triphenyl‐1H‐Imidazol‐2‐Yl) Benzene‐1,2‐Diol Derivatives DOI
Sathish Thanigachalam, Mahabarathi Subramaniyan, Shivabasayya V. Salimath

и другие.

Applied Organometallic Chemistry, Год журнала: 2025, Номер 39(6)

Опубликована: Май 25, 2025

ABSTRACT A series of eight heteroleptic derivatives titanium(IV) has been synthesized and characterized systematically employing physico‐chemical methods. Derivatives Ti 1 [(C 37 H 32 N 2 O 6 )Ti], 38 34 3 31 FN 4 ClN 5 BrN 8 7 F )Ti] were developed by refluxing an anhydrous benzene solution Ti(OPr i ) , acetylacetone, appropriate bidentate ligands (L ‑L in 1:2:1 stoichiometry. The electronic structure properties complexes (Ti ‑Ti studied density functional theory (DFT). UV–Visible method was used to determine the stability at periodic intervals. Binding interactions bovine serum albumin (BSA) calf thymus DNA (CT‐DNA) with corresponding assessed spectroscopic techniques such as absorption, fluorescence, circular dichroism have established intercalation static quenching for BSA effective manner. docking investigations also revealed that ‐Ti are well engaged via intercalative mode favorably occupy active site protein through hydrogen bonding. Furthermore, cytotoxicity against A549 (lung carcinoma) cell lines MTT (methylthiazolyldiphenyl‐tetrazolium) assay, IC 50 values found be range from 16.77 75.60 μM. displayed significant apoptosis induced cycle arrest G phase line.

Язык: Английский

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