Fe-quercetin nanozyme: unveiling the chemistry of phenol metal-ligand complexes in reactive oxygen species scavenging DOI

Sarthak Bansal,

Akanksha Deshwal, Priti Singh

и другие.

Advances in Natural Sciences Nanoscience and Nanotechnology, Год журнала: 2025, Номер 16(2), С. 025013 - 025013

Опубликована: Апрель 17, 2025

Abstract Reactive oxygen species (ROS) are necessary for cellular metabolism and defence signals, however, imbalanced amounts can lead to major health consequences. Conventional methods use natural enzymes as well chemical antioxidants scavenging ROS. Natural exhibit limitations related stability, cost-effectiveness, efficacy in physiological environments. To address these challenges, we synthesized an iron-quercetin (FeQ) coupled nanozyme that integrates iron's catalytic characteristics with quercetin’s antioxidant capabilities. The ROS activity of was analyzed using crystal violet dye Fenton reaction. We optimized various factors influence FeQ activity, including hydrogen peroxide (H 2 O ), dye, concentrations. This research evaluates the effect H on generation across a concentration range 1–15 mM, demonstrating 10 mM achieved degradation efficiency 65.7%. optimal concentrations were determined between 68.6 274.4 μM, achieving 75.78% 137.2 μM. impact evaluated at ranging from 0.04 0.1 mg ml −1 , notable observed 0.08 resulting 72.48%. nanozyme, effectively scavenged while maintaining integrity Approximately 70% degraded under control conditions, but only 8% presence nanozymes. nanozymes properties suggest therapeutic implications neurological disorders, cancer, inflammation.

Язык: Английский

Auriferous Nanozymes: Advances in diagnostic and therapeutic applications DOI
Akanksha Deshwal, Ravi Mani Tripathi, Kirti Saxena

и другие.

Nanotechnology, Год журнала: 2024, Номер 35(50), С. 502003 - 502003

Опубликована: Сен. 25, 2024

Nanozymes are a group of nanomaterials that garnered significant attention due to their enzyme-mimicking properties and catalytic activities comparable those natural enzymes. The ability nanozymes emulate crucial biological processes which can conquer the drawbacks enzymes, such as restricted thermostability well substrate range. Auriferous (gold) possess remarkable enzyme-like properties, reductase, peroxidase, superoxide dismutase, oxidase, catalase. This characteristic makes them strong competitor for possible applications in fields biomedicine biochemical analysis, especially when compared along with simple manufacturing, adaptable features, biocompatibility, affordability. review evaluates factors affect activity auriferous nanozymes. We offer thorough investigation diagnostic applications, including detecting cancer, microorganisms, glucose, cysteine, uric acid. Furthermore, we delve into gold nanozyme therapeutics chemodynamic therapy, radiotherapy, photothermal therapy. In contrast previous review, our highlights various advantages diagnostics therapies provides novel insights diverse encompassing current research studies.

Язык: Английский

Процитировано

4
Research progress on the synthesis, performance regulation, and applications of Prussian blue nanozymes DOI
Yiyang Wang, Lei Gao, Yue Cao

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 295, С. 139535 - 139535

Опубликована: Янв. 5, 2025

Язык: Английский

Процитировано

0
Colorimetric and smartphone-based dual modality sensing platform for detection of ascorbic acid DOI
Ekta Arjundas Kukreja, Ravi Mani Tripathi, Sang J. Chung

и другие.

Sensors and Actuators A Physical, Год журнала: 2025, Номер unknown, С. 116573 - 116573

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Fe-quercetin nanozyme: unveiling the chemistry of phenol metal-ligand complexes in reactive oxygen species scavenging DOI

Sarthak Bansal,

Akanksha Deshwal, Priti Singh

и другие.

Advances in Natural Sciences Nanoscience and Nanotechnology, Год журнала: 2025, Номер 16(2), С. 025013 - 025013

Опубликована: Апрель 17, 2025

Abstract Reactive oxygen species (ROS) are necessary for cellular metabolism and defence signals, however, imbalanced amounts can lead to major health consequences. Conventional methods use natural enzymes as well chemical antioxidants scavenging ROS. Natural exhibit limitations related stability, cost-effectiveness, efficacy in physiological environments. To address these challenges, we synthesized an iron-quercetin (FeQ) coupled nanozyme that integrates iron's catalytic characteristics with quercetin’s antioxidant capabilities. The ROS activity of was analyzed using crystal violet dye Fenton reaction. We optimized various factors influence FeQ activity, including hydrogen peroxide (H 2 O ), dye, concentrations. This research evaluates the effect H on generation across a concentration range 1–15 mM, demonstrating 10 mM achieved degradation efficiency 65.7%. optimal concentrations were determined between 68.6 274.4 μM, achieving 75.78% 137.2 μM. impact evaluated at ranging from 0.04 0.1 mg ml −1 , notable observed 0.08 resulting 72.48%. nanozyme, effectively scavenged while maintaining integrity Approximately 70% degraded under control conditions, but only 8% presence nanozymes. nanozymes properties suggest therapeutic implications neurological disorders, cancer, inflammation.

Язык: Английский

Процитировано

0