The COVID-19 legacy: consequences for the human DNA methylome and therapeutic perspectives DOI Creative Commons
Carlo Gaetano, Sandra Atlante, Michela Gottardi Zamperla

и другие.

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

Abstract The COVID-19 pandemic has left a lasting legacy on human health, extending beyond the acute phase of infection. This article explores evidence suggesting that SARS-CoV-2 infection can induce persistent epigenetic modifications, particularly in DNA methylation patterns, with potential long-term consequences for individuals’ health and aging trajectories. review discusses methylation-based biomarkers, such as clocks, to identify individuals at risk accelerated tailor personalized interventions. Integrating clock analysis into clinical management could mark new era treatment COVID-19, possibly helping clinicians understand patient susceptibility severe outcomes establish preventive strategies. Several valuable reviews address role epigenetics infectious diseases, including Sars-CoV-2 However, this provides an original overview current understanding dimensions offering insights implications pandemic. While acknowledging limitations data, we emphasize need future research unravel precise mechanisms underlying COVID-19-induced changes explore approaches target these modifications. Graphical Abstract: Impact landscape individual response Following infection, may develop either normal immune or aberrant one, cytokine storm. Both scenarios result long-lasting consequences, known “long COVID.” condition reshape by altering contributing “epigenetic drift.” drift, further influenced various factors, lead gene expression, functionality, disease susceptibility. One significant consequence drift is acceleration biological aging, which profoundly impact medical Created BioRender.com.

Язык: Английский

The COVID-19 legacy: consequences for the human DNA methylome and therapeutic perspectives DOI Creative Commons
Carlo Gaetano, Sandra Atlante, Michela Gottardi Zamperla

и другие.

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

Abstract The COVID-19 pandemic has left a lasting legacy on human health, extending beyond the acute phase of infection. This article explores evidence suggesting that SARS-CoV-2 infection can induce persistent epigenetic modifications, particularly in DNA methylation patterns, with potential long-term consequences for individuals’ health and aging trajectories. review discusses methylation-based biomarkers, such as clocks, to identify individuals at risk accelerated tailor personalized interventions. Integrating clock analysis into clinical management could mark new era treatment COVID-19, possibly helping clinicians understand patient susceptibility severe outcomes establish preventive strategies. Several valuable reviews address role epigenetics infectious diseases, including Sars-CoV-2 However, this provides an original overview current understanding dimensions offering insights implications pandemic. While acknowledging limitations data, we emphasize need future research unravel precise mechanisms underlying COVID-19-induced changes explore approaches target these modifications. Graphical Abstract: Impact landscape individual response Following infection, may develop either normal immune or aberrant one, cytokine storm. Both scenarios result long-lasting consequences, known “long COVID.” condition reshape by altering contributing “epigenetic drift.” drift, further influenced various factors, lead gene expression, functionality, disease susceptibility. One significant consequence drift is acceleration biological aging, which profoundly impact medical Created BioRender.com.

Язык: Английский

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