Role of Cyclins and Cytoskeletal Proteins in Endometriosis: Insights into Pathophysiology

Cancers, Год журнала: 2024, Номер 16(4), С. 836 - 836

Опубликована: Фев. 19, 2024

Endometriosis is a gynecological condition where endometrium-like tissue grows outside the uterus, posing challenges in understanding and treatment. This article delves into deep cellular molecular processes underlying endometriosis, with focus on crucial roles played by cyclins cytoskeletal proteins its pathogenesis, particularly context of Epithelial–Mesenchymal Transition (EMT). The investigation begins examining activities cyclins, elucidating their diverse biological such as cell cycle control, proliferation, evasion apoptosis, angiogenesis among ectopic endometrial cells. A comprehensive analysis follows, emphasizing fundamental specific significance to endometriotic features. review sheds light interconnected pathways through which converge, contributing genesis progression endometriosis. Understanding these complexities not only provides insight causes disease but also holds promise for development therapeutic approaches, ushering new era management this devastating disorder.

Язык: Английский

---

Cell cycle checkpoint revolution: targeted therapies in the fight against malignant tumors

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Окт. 11, 2024

Malignant tumors are among the most important causes of death worldwide. The pathogenesis a malignant tumor is complex and has not been fully elucidated. Studies have shown that such related to abnormal cell cycle progression. expression levels cyclins, cyclin-dependent kinases (CDKs), CDK inhibitors as well functions checkpoints determine whether progression smooth. Cell-cycle-targeting drugs advantages high specificity, low toxicity, side effects, drug resistance. Identifying target applying them in clinical treatments expected promote chemotherapeutic developments against tumors. This article aims review targeted their action mechanisms.

Язык: Английский

---

CELF Family Proteins in Cancer: Highlights on the RNA-Binding Protein/Noncoding RNA Regulatory Axis

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(20), С. 11056 - 11056

Опубликована: Окт. 14, 2021

Post-transcriptional modifications to coding and non-coding RNAs are unquestionably a pivotal way in which human mRNA protein diversity can influence the different phases of transcript's life cycle. CELF (CUGBP Elav-like family) proteins RBPs (RNA-binding proteins) with pleiotropic capabilities RNA processing. Their responsibilities extend from alternative splicing transcript editing nucleus stability, translation into cytoplasm. In this way, family members have been connected global alterations cancer proliferation invasion, leading their identification as potential tumor suppressors or even oncogenes. Notably, genetic variants, splicing, phosphorylation, acetylation, subcellular distribution, competition other RBPs, ultimately lncRNAs, miRNAs, circRNAs all impact regulation. Discoveries emerged about control functions, particularly via noncoding RNAs, identified competing, antagonizing, regulating agents biogenesis. On hand, CELFs an intriguing example through broaden our understanding RBP/noncoding regulatory axis. Balancing these complex pathways is undeniably deserves further research. This review outlines some mechanisms regulation functional consequences physiology.

Язык: Английский

---

Mechanisms of resistance to cyclin-dependent kinase 4/6 inhibitors

Molecular Biology Reports, Год журнала: 2021, Номер 48(1), С. 915 - 925

Опубликована: Янв. 1, 2021

Язык: Английский

---

Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells

Cancers, Год журнала: 2021, Номер 13(22), С. 5741 - 5741

Опубликована: Ноя. 16, 2021

Cannabinoid receptors, which are widely distributed in the body, have been considered as possible pharmacological targets for management of several tumors. type 2 receptors (CB2Rs) belong to G protein-coupled receptor family and mainly expressed hematopoietic immune cells, such B-cells, T-cells, macrophages; thus, CB2R activation might be useful treating cancers affecting plasma multiple myeloma (MM). Previous studies shown that stimulation may anti-proliferative effects; therefore, purpose present study was explore antitumor effect beta-caryophyllene (BCP), a agonist, an vitro model MM. Dexamethasone-resistant (MM.1R) sensitive (MM.1S) human cell lines were used this study. Cells treated with different concentrations BCP 24 h, group cells pre-incubated AM630, specific antagonist. treatment reduced proliferation through stimulation; notably, considerably increased pro-apoptotic protein Bax decreased anti-apoptotic molecule Bcl-2. Furthermore, increase caspase 3 levels detected following incubation, thus demonstrating its apoptosis activation. In addition, regulated AKT, Wnt1, beta-catenin expression, showing decrease cancer by modulating Wnt/β-catenin signaling. These effects counteracted AM630 co-incubation, confirming BCP's mechanism action is related modulation. A β-catenin impaired cycle especially promoted cyclin D1 CDK 4/6 reduction. Taken together, these data revealed significant effective anti-cancer MM activating apoptosis, molecular pathways, downregulating cycle.

Язык: Английский

---