Intermittent fasting and longevity: From animal models to implication for humans

Ageing Research Reviews, Год журнала: 2024, Номер 96, С. 102274 - 102274

Опубликована: Март 17, 2024

Язык: Английский

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Nicotinamide: A Multifaceted Molecule in Skin Health and Beyond

Medicina, Год журнала: 2025, Номер 61(2), С. 254 - 254

Опубликована: Фев. 1, 2025

Nicotinamide (NAM), the amide form of vitamin B3, is a precursor to essential cofactors nicotinamide adenine dinucleotide (NAD⁺) and NADPH. NAD⁺ integral numerous cellular processes, including metabolism regulation, ATP production, mitochondrial respiration, reactive oxygen species (ROS) management, DNA repair, senescence, aging. NAM supplementation has demonstrated efficacy in restoring energy, repairing damage, inhibiting inflammation by suppressing pro-inflammatory cytokines release. Due its natural presence variety foods excellent safety profile—even at high doses up 3 g/day—NAM extensively used chemoprevention non-melanoma skin cancers treatment dermatological conditions such as blistering diseases, atopic dermatitis, rosacea, acne vulgaris. Recently, anti-aging properties have elevated NAM’s prominence skincare formulations. Beyond repair energy replenishment, significantly impacts oxidative stress reduction, cell cycle apoptosis modulation. Despite these multifaceted benefits, comprehensive molecular mechanisms underlying actions remain not fully elucidated. This review consolidates recent research shed light on mechanisms, emphasizing critical role health therapeutic potential. By enhancing our understanding, this work underscores importance continued exploration into applications, aiming inform future clinical practices innovations.

Язык: Английский

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Alternative NADH dehydrogenase: A complex I backup, a drug target, and a tool for mitochondrial gene therapy

Biochimica et Biophysica Acta (BBA) - Bioenergetics, Год журнала: 2024, Номер 1866(2), С. 149529 - 149529

Опубликована: Ноя. 28, 2024

Язык: Английский

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2,4-Dinitrophenol is toxic on a low caloric diet but extends lifespan of Drosophila melanogaster on nutrient-rich diets without an impact on metabolism

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 30, 2024

Uncouplers of mitochondrial electron transport chain, such as 2,4-dinitrophehol (DNP), can mimic calorie restriction by decreasing efficiency adenosine triphosphate (ATP) synthesis. However, DNP is also a toxic substance, whose overdosage be lethal. In the fruit fly, Drosophila melanogaster model, we have found that in concentrations 0.05–0.2 g/L, led to drastic decrease fly survival on low caloric diet (1% sucrose and 1% yeast; 1S-1Y). On 5S-5Y diet, decreased lifespan flies reared only concentration 0.2 whilst 15S-15Y either did not significantly shortened or extended it. The extension high with was accompanied lower activity lactate dehydrogenase activities respiratory chain complexes I, II, V, determined blue native electrophoresis followed in-gel assays. exposure affect key glycolytic enzymes, antioxidant related markers oxidative stress, aconitase amount protein carbonyls. Consumption DNP-supplemented flies’ resistance heat though made male slightly more resistant starvation compared males control food. We observe substantial changes contents metabolic stores, triacylglycerols glycogen, DNP-treated flies. All this suggest nutrient-rich diets provide effective protection against DNP, providing mild uncoupling allows without considerable metabolism.

Язык: Английский

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2,4-Dinitrophenol is toxic on a low caloric diet but extends lifespan of Drosophila melanogaster on nutrient-rich diets without an impact on metabolism

Biogerontology, Год журнала: 2024, Номер 26(1)

Опубликована: Дек. 19, 2024

Язык: Английский

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Posttraumatic Stress Disorder and the Mitochondria

Опубликована: Янв. 1, 2024

Язык: Английский

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