
Biomolecules, Год журнала: 2025, Номер 15(2), С. 220 - 220
Опубликована: Фев. 3, 2025
Collagen peptides, as a natural source of possess multiple advantages such anti-aging, anti-inflammatory properties, tissue repair, and the ability to inhibit melanin production. In this study, type I collagen extracted from pig skin was hydrolyzed with 1% 3% hydrochloric acid, yielding peptides CPH1 CPH3. The content tyrosinase activity in B16F10 cells were compared via direct paracrine action when CPH3 used interfere melanogenesis. It found that significantly inhibited melanogenesis through involving HaCaT keratinocytes. intracellular measured at 65.23 ± 1.30%, mRNA levels microphthalmia transcription factor 55.77 6.09% 50.70 8.18% negative control, respectively. Furthermore, pigment deposition assays zebrafish showed that, concentration 1.0 mg/mL, control. Finally, inhibitory identified peptide segment sequence identification molecular dynamics simulation. Nona-AGPPGFPGA, Octa-APGPVGPA, Octa-GLPGPPGP have double effect on inhibition cells.
Язык: Английский