Immunogenic cell death in cancer: concept and therapeutic implications

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Март 2, 2023

Abstract Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant cell death that elicits adaptive immune responses. As immunogenic (ICD) only occur in precise cellular and organismal context, it should be conceptually differentiated from instances immunostimulation or inflammatory responses do not mechanistically depend on demise. Here, we critically discuss key conceptual mechanistic aspects ICD its implications for cancer (immuno)therapy.

Язык: Английский

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Autophagy in Its (Proper) Context: Molecular Basis, Biological Relevance, Pharmacological Modulation, and Lifestyle Medicine

International Journal of Biological Sciences, Год журнала: 2024, Номер 20(7), С. 2532 - 2554

Опубликована: Янв. 1, 2024

Autophagy plays a critical role in maintaining cellular homeostasis and responding to various stress conditions by the degradation of intracellular components.In this narrative review, we provide comprehensive overview autophagy's molecular basis, biological significance, pharmacological modulation, its relevance lifestyle medicine.We delve into intricate mechanisms that govern autophagy, including macroautophagy, microautophagy chaperone-mediated autophagy.Moreover, highlight significance autophagy aging, immunity, metabolism, apoptosis, tissue differentiation systemic diseases, such as neurodegenerative or cardiovascular diseases cancer.We also discuss latest advancements modulation their potential implications clinical settings.Finally, explore intimate connection between factors emphasizing how nutrition, exercise, sleep patterns environmental can significantly impact autophagic process.The integration medicine research opens new avenues for promoting health longevity through personalized interventions.

Язык: Английский

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Molecular determinants of immunogenic cell death elicited by radiation therapy

Immunological Reviews, Год журнала: 2023, Номер 321(1), С. 20 - 32

Опубликована: Сен. 7, 2023

Summary Cancer cells undergoing immunogenic cell death (ICD) can initiate adaptive immune responses against dead cell‐associated antigens, provided that (1) said antigens are not perfectly covered by central tolerance (antigenicity), (2) occurs along with the emission of immunostimulatory cytokines and damage‐associated molecular patterns (DAMPs) actively engage effector mechanisms (adjuvanticity), (3) microenvironment dying is permissive for initiation immunity. Finally, ICD‐driven only operate exert cytotoxic functions if target cancer enables infiltration activity. Multiple forms radiation, including non‐ionizing (ultraviolet) ionizing elicit bona fide ICD as they increase both antigenicity adjuvanticity cells. Here, we review determinants elicited radiation critically discuss strategies to reinforce immunogenicity succumbing clinically available strategies.

Язык: Английский

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Molecular targets of spermidine: implications for cancer suppression

Cell Stress, Год журнала: 2023, Номер 7(7), С. 50 - 58

Опубликована: Июнь 26, 2023

Spermidine is a ubiquitous, natural polyamine with geroprotective features. Supplementation of spermidine extends the lifespan yeast, worms, flies, and mice, dietary intake correlates reduced human mortality. However, crucial role polyamines in cell proliferation has also implicated metabolism neoplastic diseases, such as cancer. While depleting intracellular biosynthesis halts tumor growth mouse models, lifelong external administration mice does not increase cancer incidence. In contrast, series recent findings points to anti-neoplastic properties context immunotherapy. Various molecular mechanisms for anti-aging anti-cancer have been proposed, including promotion autophagy, enhanced translational control, augmented mitochondrial function. For instance, allosterically activates trifunctional protein (MTP), bipartite complex that mediates three four steps fatty acid (β-oxidation. Through this action, supplementation able restore MTP-mediated respiratory capacity naïve CD8+ T cells juvenile levels thereby improves activation aged mice. Here, we put finding into previously described target space spermidine.

Язык: Английский

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Dietary intake of polyamines in a Spanish adult population: Age-dependent and correlation with the healthy dietary index and dietary inflammatory index scores

Nutrition, Год журнала: 2024, Номер 130, С. 112608 - 112608

Опубликована: Окт. 28, 2024

Язык: Английский

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Harnessing Autophagy to Overcome Antigen-Specific T-Cell Dysfunction: Implication for People Living with HIV-1

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 11018 - 11018

Опубликована: Июль 3, 2023

Like other chronic viral infections, HIV-1 persistence inhibits the development of antigen-specific memory T-cells, resulting in exhaustion immune response and inflammation. Autophagy is a major lysosome-dependent mechanism intracellular large-target degradation such as lipid protein aggregates, damaged organelles, pathogens. Although it known that autophagy may target for elimination, knowledge its function metabolic contributor infection only infancy. Recent data show elite controllers (EC), who are HIV-1-infected subjects with natural long-term antigen (Ag)-specific T-cell protection against virus, characterized by distinct autophagy-dependent features their T-cells compared to people living (PLWH). Despite durable control antiretroviral therapy (ART), HIV-1-specific dysfunction does not normalize non-controller PLWH. Therefore, hypothesis inducing strengthen Ag-specific immunity starts be an enticing concept. The aim this review critically analyze promises potential limitations pharmacological dietary interventions activate attempt rescue among

Язык: Английский

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Cellular senescence and aging at the crossroad between immunity and cancer

Methods in cell biology, Год журнала: 2024, Номер unknown, С. xvii - xxiv

Опубликована: Янв. 1, 2024

Язык: Английский

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