Plant‐derived extracellular vesicles: Current status and challenges for developing a new paradigm in therapeutics development
View,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Abstract
Extracellular
vesicles
(EVs)
are
nano‐sized
surrounded
by
a
lipid
bilayer
containing
bioactive
materials,
including
proteins,
nucleic
acids,
lipids,
and
metabolites.
They
function
as
messengers
secreted
cells,
playing
crucial
role
in
cell‐to‐cell
communication.
Plant‐derived
extracellular
(P‐EVs),
plant
being
investigated
therapeutic
agents
drug
delivery
carriers
due
to
their
high
biocompatibility,
productivity,
effective
cellular
delivery,
exerting
effects
through
physiological
pathways.
However,
methods
for
EV
production
directly
from
plants
P‐EV
identification
components
have
not
yet
been
established.
A
comprehensive
understanding
of
the
potential
biodistribution
P‐EVs
is
essential
application
systemic
therapeutics
carriers.
This
review
covers
recent
separating
explores
identification.
It
also
summarizes
intrinsic
applications
engineered
P‐EVs.
Finally,
it
provides
tailored
strategies
examining
according
route
administration
analyzing
application.
Given
diversity
distinctiveness
plants,
development
using
shows
great
promise
anticipated
create
new
paradigm
therapeutics.
Язык: Английский
Use of Exosomes for Cosmetics Applications
Cosmetics,
Год журнала:
2025,
Номер
12(1), С. 9 - 9
Опубликована: Янв. 13, 2025
This
study
addresses
a
significant
gap
in
the
clinical
validation
and
standardization
of
exosome-based
applications
within
domains
cosmetics
regenerative
medicine.
Despite
offering
thorough
overview
potential
therapeutic
benefits
underlying
mechanisms
exosomes,
manuscript
underscores
several
unresolved
challenges,
including
paucity
evidence,
regulatory
barriers,
inconsistencies
standardization,
incomplete
mechanistic
understanding.
The
primary
aim
this
research
is
to
conduct
systematic
comprehensive
review
existing
studies
on
exosomes
skincare.
To
achieve
this,
literature
was
performed,
drawing
major
medical
database
PubMed.
approach
facilitated
collection
meta-analysis
relevant
data,
ensuring
rigorous
assessment
recent
advancements
exosome
research.
main
outcomes
highlight
multifaceted
roles
promoting
skin
rejuvenation
mitigating
signs
aging.
Specific
discussed
include
pigmentation
correction,
wound
healing,
tissue
repair,
innovative
delivery
mechanisms.
Moreover,
examines
emerging
plastic
surgery
Challenges
limitations,
such
as
constraints,
hurdles,
need
for
further
validation,
are
critically
analyzed,
providing
framework
future
directions.
Язык: Английский
The Role of Bovine Milk-Derived Exosomes in Human Health and Disease
Molecules,
Год журнала:
2024,
Номер
29(24), С. 5835 - 5835
Опубликована: Дек. 11, 2024
Bovine
milk
is
widely
recognized
as
one
of
the
most
valuable
sources
nutrients
such
proteins,
fats,
vitamins,
and
minerals
that
support
development
health
body.
In
recent
years,
there
has
been
increasing
scientific
interest
in
exosomes,
small
membrane-bound
vesicles
found
milk.
Through
their
content
(e.g.,
microRNA),
exosomes
can
influence
gene
expression
modulate
key
signaling
pathways
within
target
cells.
Results
from
vitro
vivo
studies
have
shown
bovine
milk-derived
alleviate
intestinal
inflammation
by
regulating
positively
influencing
composition
gut
microbiota.
They
also
improve
cognitive
function
nervous
system
regeneration.
addition,
promote
bone
stimulating
osteoblast
formation
inhibiting
resorption,
helping
to
prevent
osteoporosis.
Studies
beneficial
effects
on
skin
promoting
collagen
production,
protecting
cells
oxidative
stress,
delaying
ageing
process.
are
a
promising
tool
for
treatment
prevention
variety
diseases,
particularly
those
related
tissue
Although
these
results
promising,
further
needed
fully
understand
mechanisms
action
potential
clinical
application
different
diseases.
Язык: Английский