Trajectories of Single- or Multiple-Substance Use in a Population Representative Sample of Adolescents: Association with Substance-Related and Psychosocial Problems at Age 17

Brain Sciences, Год журнала: 2025, Номер 15(4), С. 331 - 331

Опубликована: Март 22, 2025

Background: Research is limited regarding the relationship between adolescent substance use and polysubstance (SU/PSU) as well their outcomes later in adolescence, while accounting for early risk factors. This study explored substance-related psychosocial at age 17 associated with SU/PSU developmental trajectories a population-representative cohort from Quebec, Canada (N = 1593; 48.4% male), controlling preadolescent individual, familial, social included concurrent of alcohol (AL), cannabis (CA), other illicit drugs (ODs). Methods: Self-reported data were collected ages 12, 13, 15, 17. Latent growth modeling identified five trajectories: Non-Users (12.8%) four classes (5.8–37.5%) varying severity based on onset, frequency, type. Multinomial regression, using non-users reference group, assessed trajectory associations age-17 outcomes. Individual, factors 10–12 served control variables. Results: Adolescents high-risk showed most negative compared to lower-risk classes. Lower-risk higher maladjustment than non-users. Conclusions: The findings highlight dose–response late-adolescent outcomes, independent Results emphasize importance longitudinal studies that incorporate multiple substances better capture complexity teenagers’ involvement throughout adolescence.

Язык: Английский

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Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Апрель 7, 2022

Globally, millions of people suffer from various substance use disorders (SUD), including mono-and polydrug opioids and methamphetamine. Brain regions such as the cingulate cortex, infralimbic dorsal striatum, nucleus accumbens, basolateral central amygdala have been shown to play important roles in addiction-related behavioral changes. Clinical pre-clinical studies characterized these brain their corresponding neurochemical changes numerous phases drug dependence acute use, intoxication, craving, withdrawal, relapse. At present, many reported individual effects However, little is known about combined effects. Co-use drugs produces greater than either alone, where one decreases side other, combination a prolonged intoxication period or more desirable effect. An increasing number associated abuse with poorer treatment outcomes, drug-related deaths, severe psychopathologies. To date, pharmacological efficacy for vague, still at experimental stage. This present review discusses human animal behavioral, neuroanatomical, underlying both morphine methamphetamine separately, well its combination. narrative also delineates recent advances pharmacotherapy mono- poly drug-use clinical preclinical stages.

Язык: Английский

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The interdependence of cigarette, alcohol, and marijuana use in the context of school-based social networks

PLoS ONE, Год журнала: 2018, Номер 13(7), С. e0200904 - e0200904

Опубликована: Июль 20, 2018

The concurrent or sequential usage of multiple substances during adolescence is a serious public health problem. Given the importance understanding interdependence in substance use adolescence, purpose this study to examine co-evolution cigarette smoking, alcohol, and marijuana within ever-changing landscape adolescent friendship networks, which are primary socialization context for use. Utilizing Stochastic Actor-Based models, we how simultaneous social processes co-evolve with drinking, networks using two school samples from early waves National Longitudinal Study Adolescent Adult Health (Add Health). We also estimate separate models examining effects one initiation cessation other each sample. Based on initial model results, simulate forward time by turning off key effect estimated at time, observe distribution changes. find evidence unilateral causal relationship subsequent smoking drinking behaviors, resulting behavior. Marijuana associated low level, high level. In addition, simulation excluding behavior, number smokers drinkers decreases precipitously. Overall, our findings indicate some drug use, as increased behavior that an adolescent's level affects continuation drinking.

Язык: Английский

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Substance use classes and symptoms of anxiety and depression among Canadian secondary school students

Health Promotion and Chronic Disease Prevention in Canada, Год журнала: 2021, Номер 41(5), С. 153 - 164

Опубликована: Май 1, 2021

Few studies have assessed patterns of substance use among Canadian adolescents. This cross-sectional study examined classes secondary school students and associations with anxiety depression.This used data from Year 6 (2017/18) the COMPASS study. Students (n = 51 767) reported their (alcohol, cannabis, cigarette e-cigarette use) depression symptoms. We employed latent class analysis to identify multinomial logistic regression examine how were associated membership.Overall, 40% indicated having and/or (50% in females; 29% males) 60% (60% 61% males). identified three classes: poly-use, dual use, non-use. Females both had highest odds being poly-use compared non-use (odds ratio [OR] 4.09; 95% confidence interval [CI]: 3.59-4.65) followed by females only (OR 2.65; CI: 2.31-3.04) males 2.48; 2.19-2.80). Symptomatology was also belonging except 1.13; 0.94-1.37).Canadian are engaging poly-substance such use. a higher prevalence should be priority population for mental health programming.Peu d’études ont évalué les habitudes de consommation substances chez adolescents canadiens. Cette étude transversale porte sur catégories élèves du secondaire au Canada et leurs avec l’anxiété la dépression.Cette repose des données l’année (2017-2018) l’étude COMPASS. Les fait état leur (alcool, cigarettes électroniques) symptômes d’anxiété dépression. Nous avons utilisé une analyse par latentes pour créer régression logistique multinomiale examiner manière dont dépression étaient associées à l’appartenance catégorie.Dans l’ensemble, 40 % indiqué souffrir ou (50 filles 29 garçons) 60 d’une (60 61 garçons). établi trois : polyconsommation, double non-consommation. plus susceptibles d’appartenir catégorie polyconsommation plutôt qu’à non-consommation souffrant fois (rapport cote [RC] 4,09; intervalle confiance [IC] 95 3,59 4,65]), suivies uniquement (RC 2,65; IC 2,31 3,04) garçons 2,48; 2,19 2,80). La symptomatologie également été associée consommation, sauf 1,13; 0,94 1,37).Les s’adonnent substances, on pu associer ces types consommation. affichent prévalence élevée devraient, ce fait, constituer priorité en matière programmation santé mentale.40% vs. 29%). Overall, class.40 substances. affichaient contre %). De générale, relever

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The Mood Boost from Tobacco Cigarettes is More Erratic with the Additions of Cannabis and Alcohol

Nicotine & Tobacco Research, Год журнала: 2022, Номер 24(8), С. 1169 - 1176

Опубликована: Янв. 5, 2022

A large body of literature indicates that nicotine results in an acute mood "boost," including increased positive affect and decreased negative affect. Young adults frequently engage polysubstance use cigarettes with cannabis alcohol-a trend is likely to accelerate the expanding legalization cannabis. However, little known about whether use, defined here as combustible tobacco cigarette within same hour alcohol, associated changes boost. The present study aimed address this gap.Young (N = 202, 52% female, mean age 21 years at time 1) provided ecological moments assessment (EMA) reports over two 7-day bursts spaced 1 year apart. In each report, participants rated levels before after smoking, indicated alcohol use. Mixed-effects location-scale modeling simultaneously tested variability related smoking events and/or compared smoking-only events.From decreased, on average. Overall, additions had nonsignificant associations these changes. well cigarette-cannabis co-use, were significantly greater within-person smoking.The benefits more erratic contexts co-use. Potential implications for young adults' long-term trajectories are discussed.Among who smoke cigarettes, "boost" from may be erratic-which say, either amplified or attenuated-with together, alone. On occasions when seek out enhance their boost, but instead experience a dampening effect, they might consume nicotine, contributing dependence. Future investigation warranted, particular attention nicotine-cannabis

Язык: Английский

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Intergenerational residential school attendance and increased substance use among First Nation adults living off-reserve: An analysis of the aboriginal peoples survey 2017

Frontiers in Public Health, Год журнала: 2023, Номер 10

Опубликована: Янв. 20, 2023

Introduction The Truth and Reconciliation Commission of Canada (TRCC) published 94 Calls to Action in 2015 address long-term, intergenerational effects the residential school system, highlighting pervasive impact colonialism on wellbeing Indigenous peoples Canada. Indeed, research with populations has captured that prior experiences schools contributes transmission mental physical health disparities. Despite these studies, further is needed contextualizes influence within broader frameworks consider social determinants As such, purpose present study was examine patterns substance use among individuals a history attendance (RSA) reporting parent or two-generation (parent grandparent) RSA. Method Data from Aboriginal Peoples Survey (2017), involving 10,030 First Nations living off reserve, were analyzed. Results Self-reported scores significantly lower those had attended schools, whose parents grandparents when compared who did not. Further, family RSA associated increased participants, though findings variable based sex specific Meanwhile, individual not likelihood diagnosis. Discussion These provide additional support for how both parental histories are outcomes. articulate need TRCC's be actually implemented, including community-based approaches harness strength people communities aim close gap disparities their children families.

Язык: Английский

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High school sport participation and substance use: A cross-sectional analysis of students from the COMPASS study

Addictive Behaviors Reports, Год журнала: 2020, Номер 12, С. 100298 - 100298

Опубликована: Авг. 15, 2020

The objective of this study was to examine the association between participation in school sports and substance use behaviors both male female high students.The current used cross-sectional data from 60,601 students Year 6 (2017-2018) COMPASS study. Students reported their physical activity (none, intramurals only, varsity both) past 30-day (binge drinking, cannabis use, cigarette e-cigarette use). Hierarchical logistic regression models predicted odds by sex.55% did not participate any 32% use. Intramurals were negatively associated with among all females. Varsity lower males. In contrast, participating increased binge drinking students. Participating but decreased use.Intramurals found be protective against Although they a risk factor for Substance prevention efforts should focus teams, especially

Язык: Английский

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Changes in cannabis use modes among Canadian youth across recreational cannabis legalization: Data from the COMPASS prospective cohort study

Addictive Behaviors, Год журнала: 2021, Номер 122, С. 107025 - 107025

Опубликована: Июнь 23, 2021

Язык: Английский

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Prevalence Of Substance Use and Related Behaviors Among Tertiary Students: A Cross-Sectional Survey in Yaoundé, Cameroon

American Journal of Biomedical Science & Research, Год журнала: 2024, Номер 21(2), С. 120 - 128

Опубликована: Янв. 13, 2024

Background: The use of psychoactive substances is a major global public health problem. People aged 15-24 years are more likely to abuse than the general population. Substances among youth, especially students in higher education increasing rapidly worldwide. This study aimed assess prevalence university and describe their behavioral profiles.

Язык: Английский

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The Role of Attachment in Poly-Drug Use Disorder: An Overview of the Literature, Recent Findings and Clinical Implications

Frontiers in Psychiatry, Год журнала: 2019, Номер 10

Опубликована: Авг. 27, 2019

Background: Substance use disorders (SUDs) represent a worldwide epidemic with extensive costs to the individual and society. Occasionally described as an attachment disorder, they have been linked various impairments in self-regulation social functioning. However, while there significant advances development validation of treatment strategies for SUD recent years, components these approaches yet be fully explored. The characteristics polydrug disorder (PUD) especially need addressed more detail, this diagnosis is highly common individuals seeking treatment, simultaneously being associated poor success. Aim Scope: This review aims at further exploring relevance PUD its treatment. To end, provides concise summary relevant theories on general, including related parameters attachment, emotion regulation, neuroscience. Furthermore, several studies focused specifically are detail. These explored connections between personality structure, primary higher emotions (including spirituality), well structural functional neural inpatients healthy controls. Most notably, highlight that insecure structure present PUD. In addition, paralleled by white matter integrity, tracts connected facets regulation. Conclusions: Based our findings, we emphasize conceptualization Attachment Disorder, behavioral level. point out importance integrated bio-psycho-social approach research area. Consequently, future might closely focus influence attachment-based interventions regulation abilities potentially neuroplasticity. Neuroplastic changes, which still rather unexplored, important assessment outcomes long-term

Язык: Английский

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