Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: A conceptual model for the study of sex and gender differences

Frontiers in Neuroendocrinology, Год журнала: 2024, Номер 73, С. 101121 - 101121

Опубликована: Янв. 20, 2024

Язык: Английский

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Early Life Stress and Pubertal Predictors of Subsequent Substance Use in a National Diverse Sample of Adolescents: Sex and Substance Type Matter

Drug and Alcohol Dependence, Год журнала: 2025, Номер 268, С. 112551 - 112551

Опубликована: Янв. 13, 2025

Early life stress (ELS) increases the risk of substance use disorder (SUD) in adulthood. The pathway from ELS to SUD is hypothesized be influenced by sex. We examine impact on adolescent first use, a common precursor adult SUDs, and test for sex differences relationship between alcohol, nicotine, marijuana. Individuals Adolescent Brain Cognitive Development study (ABCD; N = 8608 US children aged 9-10 at baseline) were assessed multiple measures (Environmental, Family, Trauma), covariates (race/ethnicity, age months baseline, pubertal development score), use. Cox proportional hazards regression was performed total population stratified sex, generating adjusted hazard ratios (aHRs) One unit increase Total scores significantly increased aHRs all substances. Dimensional analysis revealed associations with that differed across type ELS, substance. Females higher Environmental display significant substances, while males Trauma showed nicotine marijuana Findings highlight association illustrating consistency Family risk. Existing family-based prevention intervention strategies should consider addressing protection.

Язык: Английский

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Sex Differences in E-Cigarette Use and Related Health Effects

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(22), С. 7079 - 7079

Опубликована: Ноя. 18, 2023

Background: Electronic cigarettes (e-cigarettes) comprise a variety of products designed to deliver nicotine, flavorings, and other substances. To date, multiple epidemiological experimental studies have reported health issues associated with their use, including respiratory toxicity, exacerbation conditions, behavioral physiological effects. While some these effects appear be sex- and/or gender-related, only portion the research has been conducted considering variables. In this review, we sought summarize available literature on sex-specific sex gender differences, predictors risk factors, organ systems, Methods: We searched selected articles from 2018–2023 that included as variable or differences e-cigarette-associated Results: found 115 relevant published since 2018 in outcomes. The main were related reasons for initiation, smoking history, types devices flavoring, polysubstance responses nicotine toxicants e-liquids, lung disease, factors such anxiety, depression, sexuality, bullying. Conclusions: supports notion both influence susceptibility negative e-cigarette use. Future needs consider variables when addressing toxicity health-related consequences.

Язык: Английский

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The Impact of the COVID-19 Pandemic on Adolescent Substance Use

Current Pediatrics Reports, Год журнала: 2024, Номер 12(3), С. 62 - 68

Опубликована: Июнь 26, 2024

Язык: Английский

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Unraveling Online Mental Health Through the Lens of Early Maladaptive Schemas: AI-Enabled Content Analysis of Online Mental Health Communities

Journal of Medical Internet Research, Год журнала: 2025, Номер 27, С. e59524 - e59524

Опубликована: Фев. 7, 2025

Background Early maladaptive schemas (EMSs) are pervasive, self-defeating patterns of thoughts and emotions underlying most mental health problems central in schema therapy. However, the characteristics EMSs vary across demographics, despite growing use online communities (OMHCs), how manifest these support-seeking environments remains unclear. Understanding could inform design more effective interventions powered by artificial intelligence to address support seekers’ unique therapeutic needs. Objective We aimed uncover associations between within OMHCs examine features as they reflected OMHCs. Methods curated a dataset 29,329 posts from widely accessed OMHCs, labeling each with relevant problems. To identify associations, we conducted chi-square tests independence calculated odds ratios (ORs) dataset. In addition, developed novel group-level case conceptualization technique, leveraging GPT-4 extract OMHC texts key therapy dimensions, such triggers coping responses. Results Several were identified problems, reflecting contexts. Anxiety-related typically highlighted vulnerability harm or illness (OR 5.64, 95% CI 5.34-5.96; P<.001), while depression-related emphasized unmet interpersonal needs, social isolation 3.18, 3.02-3.34; P<.001). Conversely, eating disorders mostly exemplified negative self-perception emotional inhibition 1.89, 1.45-2.46; Personality themes subjugation 2.51, 1.86-3.39; posttraumatic stress disorder involved distressing experiences mistrust 5.04, 4.49-5.66; Substance failure achieve 1.83, 1.35-2.49; Depression, personality disorders, also associated 12, 9, 7 EMSs, respectively, emphasizing their complexities need for comprehensive interventions. contrast, anxiety, disorder, substance related only 2 3 suggesting that better addressed through targeted EMS extracted our averaged 13.27 (SD 3.05) per schema, 2.65 1.07) dimension, supported existing literature. Conclusions uncovered various among seekers, highlighting prominence specific problem terms EMSs. expressed seekers reinforcing relevance These insights valuable understanding characterized can development intelligence–powered tools enhance on platforms.

Язык: Английский

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COVID-19-related stress and positive coping strategies among young adults in Canada and France: A latent class analysis

PLOS mental health., Год журнала: 2025, Номер 2(2), С. e0000261 - e0000261

Опубликована: Фев. 25, 2025

Although there is evidence describing how coping strategies can impact mental health outcomes and inequities among young adults, little known about different sub-groups of adults engage with positive the association challenges. Data were drawn from an online cross-sectional survey (July–December 2021) aged 18–30 years who reported experiencing COVID-19-related stress in Canada (n=2288) France (n=1891) during second year pandemic. Latent class analysis was used to identify classes similar strategies. Multinomial logistic regression models performed each country examine differences between these socio-demographic characteristics health. Four identified: high (33%), socially engaged (47.1%), self-care healthy lifestyle (10.1%), low (9.8%). In both countries, men more likely belong rural residents had increased likelihood belonging class. Differences varied by country. Canada, those financial difficulties classes, while, France, descendants immigrants odds Compared class, perceive not well higher rates depression, anxiety, suicidal thoughts. Our findings highlight that specific (men, rural, racialized, economically disadvantaged) may be less experience risk These also underscore importance investigating influence contextual factors on adults’ ability adopt

Язык: Английский

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Social Cognition and Substance Use

Опубликована: Янв. 1, 2025

Язык: Английский

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Virtual Substance Use Interventions for Youth: A Scoping Review of Literature

International Journal of Mental Health and Addiction, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Язык: Английский

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Loneliness, affective disorders, suicidal ideation, and the use of psychoactive substances in a sample of adolescents during the COVID‐19 pandemic: A cross‐sectional study

Journal of Child and Adolescent Psychiatric Nursing, Год журнала: 2023, Номер 36(3), С. 188 - 198

Опубликована: Март 8, 2023

Abstract Problem The global coronavirus (COVID‐19) pandemic has been challenging for adolescents. Indeed, with the closure of schools and social centers reduction extracurricular activities, increased isolation compounded difficulties in school performance, loneliness, networking. Increased risk mental health problems, substance abuse, affective disorders, suicidal ideation, suicide reported Methods This cross‐sectional study assesses association between depression, anxiety, use networks, achievement a sample Italian adolescents during COVID‐19 pandemic. also explores emotional dysregulation through disorders (depression anxiety), use, networks. comprises first second grades high pandemic; participants received an email explaining purpose e‐research. Data were collected using Strengths Difficulties Questionnaire, Achenbach System Empirically Based Assessment, Loneliness Scale. Findings A total 505 completed web survey. revealed that students experienced problems achievement, activities. mean scores depression anxiety close to borderline range. 14.3% intentionally harmed themselves or attempted suicide. Conclusions raises concerns about impacts on require attention adult reference figures who deal adolescents, such as parents, teachers, healthcare professionals. Results indicate necessity providing early interventions aimed at prevention psychopathologies promotion adolescent due

Язык: Английский

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Examining the Impact of the COVID-19 Pandemic on youth Alcohol Consumption: longitudinal Changes From Pre-to Intra-pandemic Drinking in the COMPASS Study

Journal of Adolescent Health, Год журнала: 2022, Номер 71(6), С. 665 - 672

Опубликована: Сен. 8, 2022

Язык: Английский

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