Advances in Clinical Medicine, Год журнала: 2024, Номер 14(11), С. 1337 - 1343
Опубликована: Янв. 1, 2024
Язык: Английский
Materials Today Energy, Год журнала: 2025, Номер 48, С. 101800 - 101800
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
3
Nano Trends, Год журнала: 2025, Номер unknown, С. 100087 - 100087
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
3
Elsevier eBooks, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Biosensors, Год журнала: 2025, Номер 15(3), С. 127 - 127
Опубликована: Фев. 20, 2025
MXenes, a class of two-dimensional materials, have emerged as promising candidates for developing advanced electrochemical biosensors due to their exceptional electrical conductivity, large surface area, and rich chemistry. These unique properties enable high sensitivity, rapid response, versatile functionalization, making MXene-based highly suitable detecting biomolecules pathogens in biomedical applications. This review explores recent advancements from 2020 2024, focusing on design principles, fabrication strategies, integration with microfluidic platforms enhanced performance. The potential MXene sensors achieve real-time multiplexed detection is highlighted, alongside the associated challenges. Emphasis placed role MXenes addressing critical needs disease diagnostics, personalized medicine, point-of-care testing, providing insights into future trends transformative possibilities field sensing technologies.
Язык: Английский
Процитировано
0
JOM, Год журнала: 2025, Номер unknown
Опубликована: Март 14, 2025
Язык: Английский
Процитировано
0
Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(4), С. 235 - 235
Опубликована: Март 28, 2025
Cancer is a significant global health challenge, where early diagnosis crucial for enhancing patient survival and mitigating the treatment burden on patients. Exosomes are extracellular vesicles released through fusion of multivesicular bodies with cell membranes, carrying disease-associated information from donor cells. This makes exosomes key biomarker in liquid biopsy analysis, particularly cancer detection. Developing cost-effective, straightforward, sensitive exosome biosensing technologies practical importance. To date, large number fluorescence-based biosensors have relied Fluorescence Resonance Energy Transfer (FRET) principle. review introduces basic background field principle FRET-based sensors, followed by systematic summary their progress categorized different transduction elements or mechanisms. Finally, this work discusses current challenges proposes potential solutions future prospects, aiming to encourage inspire development new approaches advanced FRET biosensors.
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 14, 2025
An electrochemical sandwich immunoassay was fabricated to measure the prostate-specific antigen (PSA) biomarker. The PSA immunosensor developed by altering surface of a glassy carbon electrode (GCE) with nanocomposite comprising carboxyl-functionalized dots that support gold nanoparticles (AuNPs), which were then combined hydroxylated boron nitride nanosheets (HO-BN). This construction possesses distinctive signal enhancement characteristics and prepared via facile method. Considering high biological affinity AuNPs for biomolecules, (CDs) carboxyl (COOH) groups make suitable substrate modification. alteration allows antibody (Ab1) attachment, resulting in sandwich-like configuration. Additionally, dot-stabilized integrated into HO-BN nanosheet nanocomposites considerably boost electron transfer rate, leading remarkable potential sensor applications. By utilizing horseradish peroxidase (HRP)-conjugated antifree (Ab2), reduction hydrogen peroxide (H2O2) achieved within cell. led increased current, attributed concentration, is required biosensor analysis perform properly. revealed linear correlation concentrations ranging from 1.0 3500 pg mL-1, achieving low detection limit 0.136 mL-1. Furthermore, aptasensor demonstrates excellent selectivity, stability, commendable reproducibility, indicating its significant clinical research diagnostic
Язык: Английский
Процитировано
0
Advances in Colloid and Interface Science, Год журнала: 2025, Номер 343, С. 103557 - 103557
Опубликована: Май 15, 2025
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Май 30, 2025
Diabetes, a widespread chronic disease, is characterized by dysregulated blood glucose levels, necessitating early diagnosis for effective management and complication prevention. To address the need more comprehensive diagnostic approach, we present novel dual-mode electrochemical biosensor capable of simultaneously detecting two clinical biomarkers─glycated albumin (GA) glucose─a combination not previously reported on single platform. While reflects immediate glycemic status, GA provides insight into short- to intermediate-term control; thus, their concurrent detection enables holistic assessment, enhancing accuracy. This simultaneous demonstrates competitive immunoassay enzymatic detection. The integrates polyethylenimine-capped gold nanoparticles, graphene oxide, two-dimensional bimetallic molybdenum tungsten disulfide onto working area screen-printed carbon electrodes, sensitivity performance. For detection, oxidase ferrocene monocarboxylic acid function as enzyme catalyst redox mediator, while immunosensor employing methylene blue signal selectively identifies GA. Differential pulse voltammetry facilitates high-precision biomarker quantification. Validated in 50-fold diluted human serum, exhibited remarkable ranges 500-25,000 pg mL-1 0.5-8.0 mM glucose, achieving limits 320 0.15 mM, respectively. By integrating fasting plasma assessments, this innovative design enhances accuracy, addressing limitations individual methods paving way robust diabetes monitoring system that transforms strategies improved patient outcomes.
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 17 - 39
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0