Promising Solutions to Address the Non-Specific Adsorption in Biosensors Based on Coupled Electrochemical-Surface Plasmon Resonance Detection

Chemosensors, Год журнала: 2025, Номер 13(3), С. 92 - 92

Опубликована: Март 5, 2025

Nonspecific adsorption (NSA) impacts the performance of biosensors in complex samples. Coupled electrochemical–surface plasmon resonance (EC-SPR) offer interesting opportunities to evaluate NSA. This review details main solutions minimize fouling electrochemical (EC), surface (SPR) and EC-SPR biosensors. The discussion was centered on blood, serum milk as examples matrices. Emphasis placed antifouling coatings, NSA evaluation protocols universal functionalization strategies obtain In last 5 years, various coatings were developed for EC biosensors, including new peptides, cross-linked protein films hybrid materials. Due comparatively much more scarce literature, SPR extended early 2010s. analysis revealed a wide range materials with tunable conductivity, thickness functional groups that can be tested future EC-SPR. high-throughput screening materials, molecular simulations machine learning-assisted evaluations will even further widen available minimization NSA’s impact analytical signal is moreover facilitated by unique sensing mechanisms associated bioreceptor or particularities detection method. It hoped this encourage research field

Язык: Английский

State-of-the-Art Signal Amplification Strategies for Nucleic Acid and Non-Nucleic Acid Biosensors

Sensors and Actuators Reports, Год журнала: 2024, Номер unknown, С. 100268 - 100268

Опубликована: Дек. 1, 2024

Язык: Английский