Mapping the knowledge domains of literature on hepatocellular carcinoma and liver failure: a bibliometric approach DOI Creative Commons
Jun Pu,

Zhao Ya-min,

Siming Zhang

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Апрель 16, 2025

Background Hepatocellular carcinoma (HCC) accounts for 75-85% of primary liver cancers, with its incidence continually rising, posing a threat to socio-economic development. Currently, resection is the standard treatment HCC. However, post-hepatectomy failure (PHLF) severe and formidable postoperative complication that increases patients’ medical expenses mortality risk. Additionally, can occur at any stage HCC development, severely affecting quality life prognosis. Method Using Web Science Core Collection, this bibliometric study analyzed English articles reviews on from 2003 2023. Bibliometric tools like CiteSpace, VOSviewer, R-studio were employed data visualization analysis, focusing publication trends, citation metrics, explosive intensity, collaborative networks. Use Comparative Toxicogenomics Genecards databases screen genes related failure, perform enrichment analyses using Gene Ontology, Kyoto Encyclopedia Genes Genomes, PubMed identified differentially expressed genes. Results The significant increase in publications key contributions journals such as World Journal Gastroenterology Hepatology. United States, China, Japan leading countries research output. Prominent authors institutions, including Kudo Masatoshi Sun Yat-sen University, identified. Enrichment analysis showed drug metabolism, oxidative stress, lipid other pathways are closely field. Research hotspots included risk prediction models novel therapies. Conclusion This highlights growing interest advancements failure. Future should focus improving prediction, developing new therapies, enhancing international collaboration address these critical health issues.

Язык: Английский

Mapping the knowledge domains of literature on hepatocellular carcinoma and liver failure: a bibliometric approach DOI Creative Commons
Jun Pu,

Zhao Ya-min,

Siming Zhang

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Апрель 16, 2025

Background Hepatocellular carcinoma (HCC) accounts for 75-85% of primary liver cancers, with its incidence continually rising, posing a threat to socio-economic development. Currently, resection is the standard treatment HCC. However, post-hepatectomy failure (PHLF) severe and formidable postoperative complication that increases patients’ medical expenses mortality risk. Additionally, can occur at any stage HCC development, severely affecting quality life prognosis. Method Using Web Science Core Collection, this bibliometric study analyzed English articles reviews on from 2003 2023. Bibliometric tools like CiteSpace, VOSviewer, R-studio were employed data visualization analysis, focusing publication trends, citation metrics, explosive intensity, collaborative networks. Use Comparative Toxicogenomics Genecards databases screen genes related failure, perform enrichment analyses using Gene Ontology, Kyoto Encyclopedia Genes Genomes, PubMed identified differentially expressed genes. Results The significant increase in publications key contributions journals such as World Journal Gastroenterology Hepatology. United States, China, Japan leading countries research output. Prominent authors institutions, including Kudo Masatoshi Sun Yat-sen University, identified. Enrichment analysis showed drug metabolism, oxidative stress, lipid other pathways are closely field. Research hotspots included risk prediction models novel therapies. Conclusion This highlights growing interest advancements failure. Future should focus improving prediction, developing new therapies, enhancing international collaboration address these critical health issues.

Язык: Английский

Процитировано

0