Journal of Biochemical and Molecular Toxicology,
Год журнала:
2024,
Номер
39(1)
Опубликована: Дек. 18, 2024
ABSTRACT
Breast
cancer
has
seriously
affected
women's
physical
and
mental
health.
This
investigation
aims
at
screening
differentially
expressed
genes
(DEGs)
in
breast
illuminating
the
potential
biological
functions
of
Leiomodin
1
(LMOD1)
its
behind
mechanisms
against
cancer.
The
common
DEGs
(co‐DEGs)
between
GSE22820
GSE29431
data
sets
pivotal
were
screened
out
using
bioinformatics
methods.
roles
LMOD1
overexpression
on
malignant
phenotypes
validated
by
functional
assays
impact
fatty
acid
synthesis
was
also
elucidated
cell
lines.
Additionally,
colivelin,
a
STAT3
activator,
applied
for
further
investigating
role
JAK2/STAT3
pathway
vitro.
A
total
208
co‐DEGs
5
focal
through
analysis,
downregulated
retarded
proliferative,
migratory,
invasive
capabilities
cells.
suppressed
synthesis.
Furthermore,
inhibitory
effects
cells
with
partially
abolished
after
colivelin
treatment.
could
impede
Our
study
highlighted
exerted
as
tumor‐suppressive
cancer,
which
correlated
restraining
activation.
Cancer Drug Resistance,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 12, 2024
Breast
cancer
is
one
of
the
most
common
cancers
in
women
globally,
posing
significant
challenges
to
treatment
because
diverse
and
complex
pathological
molecular
subtypes.
The
emergence
immune
checkpoint
inhibitors
(ICIs)
has
revolutionized
breast
cancer,
particularly
for
triple-negative
(TNBC),
significantly
improving
patient
outcomes.
However,
overall
tumor
response
rate
remains
suboptimal
due
drug
resistance
ICIs.
This
primarily
immune-suppressive
microenvironment
(TME),
cells’
ability
evade
surveillance,
other
regulatory
mechanisms.
To
address
these
challenges,
clinical
researchers
are
actively
exploring
combinatorial
therapeutic
strategies
with
Tumor
local
ablation
(TLA)
technology
anticipated
overcome
ICIs
enhance
efficacy
by
ablating
tissue,
releasing
antigens,
remodeling
TME,
stimulating
systemic
responses.
Combination
therapy
TLA
demonstrated
promising
results
preclinical
studies,
underscoring
feasibility
importance
addressing
mechanisms
cancer.
provides
novel
expected
drive
further
advancements
field.
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2024,
Номер
39(1)
Опубликована: Дек. 18, 2024
ABSTRACT
Breast
cancer
has
seriously
affected
women's
physical
and
mental
health.
This
investigation
aims
at
screening
differentially
expressed
genes
(DEGs)
in
breast
illuminating
the
potential
biological
functions
of
Leiomodin
1
(LMOD1)
its
behind
mechanisms
against
cancer.
The
common
DEGs
(co‐DEGs)
between
GSE22820
GSE29431
data
sets
pivotal
were
screened
out
using
bioinformatics
methods.
roles
LMOD1
overexpression
on
malignant
phenotypes
validated
by
functional
assays
impact
fatty
acid
synthesis
was
also
elucidated
cell
lines.
Additionally,
colivelin,
a
STAT3
activator,
applied
for
further
investigating
role
JAK2/STAT3
pathway
vitro.
A
total
208
co‐DEGs
5
focal
through
analysis,
downregulated
retarded
proliferative,
migratory,
invasive
capabilities
cells.
suppressed
synthesis.
Furthermore,
inhibitory
effects
cells
with
partially
abolished
after
colivelin
treatment.
could
impede
Our
study
highlighted
exerted
as
tumor‐suppressive
cancer,
which
correlated
restraining
activation.
