ACS Applied Bio Materials,
Год журнала:
2022,
Номер
5(9), С. 4055 - 4085
Опубликована: Авг. 18, 2022
Currently,
the
clinic's
treatment
of
acute/chronic
wounds
is
still
unsatisfactory
due
to
lack
functional
and
appropriate
wound
dressings.
Intelligent
multifunctional
dressings
are
considered
most
advanced
modalities.
It
essential
design
develop
with
required
functions
according
microenvironment
in
clinical
treatment.
This
work
summarizes
characteristics
various
common
wounds,
such
as
acute
wound,
diabetic
burns
scalded
mucosal
ulcers
wound.
Furthermore,
factors
transformation
from
chronic
were
analyzed.
Then
we
focused
on
summarizing
how
researchers
fully
thoroughly
combined
complex
modern
technology
ensure
usability
value
dressing,
photothermal-sensitive
dressings,
dressing
(pH-sensitive
ROS-sensitive
osmotic
pressure
dressings),
hemostatic
guiding
tissue
regeneration
microneedle
3D/4D
printing
Finally,
revolutionary
development
transform
existing
into
needs
soon
possible
have
carried
out
a
reasonable
meaningful
outlook.
Journal of Materials Chemistry B,
Год журнала:
2022,
Номер
10(14), С. 2384 - 2429
Опубликована: Янв. 1, 2022
The
design
of
antimicrobial
peptide-based
materials
for
biomedical
applications
such
as
fighting
infections
in
various
organs,
cancer
therapy,
gene
delivery
and
detection
bacteria.
Bioactive Materials,
Год журнала:
2022,
Номер
20, С. 610 - 626
Опубликована: Июль 1, 2022
A
novel
sprayable
adhesive
is
established
(ZnMet-PF127)
by
the
combination
of
a
thermosensitive
hydrogel
(Pluronic
F127,
PF127)
and
coordination
complex
zinc
metformin
(ZnMet).
Here
we
demonstrate
that
ZnMet-PF127
potently
promotes
healing
traumatic
skin
defect
burn
injury
promoting
cell
proliferation,
angiogenesis,
collagen
formation.
Furthermore,
find
ZnMet
could
inhibit
reactive
oxygen
species
(ROS)
production
through
activation
autophagy,
thereby
protecting
from
oxidative
stress
induced
damage
wound.
exerts
better
effects
on
wound
than
ZnCl2
or
alone.
also
displays
excellent
antibacterial
activity
against
Staphylococcus
aureus
Escherichia
coli,
which
reduce
incidence
infections.
Collectively,
PF127
be
used
as
new
drug
delivery
system
for
treatment
injury.
The
advantages
this
are
obvious:
(1)
It
convenient
to
use;
(2)
can
cover
irregular
sites
evenly
in
liquid
state.
In
with
system,
establish
it
potential
clinical
Materials Today Bio,
Год журнала:
2023,
Номер
23, С. 100823 - 100823
Опубликована: Окт. 1, 2023
Wound
care
and
treatment
can
be
critical
from
a
clinical
standpoint.
While
different
strategies
for
the
management
of
skin
wounds
have
been
developed,
limitations
inherent
in
current
approaches
necessitate
development
more
effective
alternative
strategies.
Advances
tissue
engineering
resulted
novel
promising
accelerating
wound
healing.
The
use
various
biomaterials
capable
regeneration
damaged
is
engineering.
In
this
regard,
cerium
oxide
nanoparticles
(CeO
Pharmaceutics,
Год журнала:
2022,
Номер
14(8), С. 1574 - 1574
Опубликована: Июль 28, 2022
The
healing
of
wounds
is
a
dynamic
function
that
necessitates
coordination
among
multiple
cell
types
and
an
optimal
extracellular
milieu.
Much
the
research
focused
on
finding
new
techniques
to
improve
manage
dermal
injuries,
chronic
burn
sepsis,
which
are
frequent
medical
concerns.
A
strategy
involves
developing
multifunctional
dressings
aid
innate
combat
numerous
issues
trouble
incompletely
healed
such
as
extreme
inflammation,
ischemic
damage,
scarring,
wound
infection.
Natural
origin-based
compounds
offer
distinct
characteristics,
excellent
biocompatibility,
cost-effectiveness,
low
toxicity.
Researchers
have
developed
biopolymer-based
with
drugs,
biomacromolecules,
cells
cytocompatible,
hemostatic,
initiate
skin
rejuvenation
rapid
healing,
possess
anti-inflammatory
antimicrobial
activity.
main
goal
would
be
mimic
characteristics
fetal
tissue
regeneration
in
adult
phase,
including
complete
hair
glandular
restoration
without
delay
or
scarring.
Emerging
treatments
based
biomaterials,
nanoparticles,
biomimetic
proteases
keys
improving
care
will
vital
addition
therapeutic
toolkit
for
slow-healing
wounds.
This
study
focuses
recent
discoveries
several
undergone
extensive
pre-clinical
development
now
undergoing
fundamental
research.
ACS Applied Bio Materials,
Год журнала:
2022,
Номер
5(9), С. 4055 - 4085
Опубликована: Авг. 18, 2022
Currently,
the
clinic's
treatment
of
acute/chronic
wounds
is
still
unsatisfactory
due
to
lack
functional
and
appropriate
wound
dressings.
Intelligent
multifunctional
dressings
are
considered
most
advanced
modalities.
It
essential
design
develop
with
required
functions
according
microenvironment
in
clinical
treatment.
This
work
summarizes
characteristics
various
common
wounds,
such
as
acute
wound,
diabetic
burns
scalded
mucosal
ulcers
wound.
Furthermore,
factors
transformation
from
chronic
were
analyzed.
Then
we
focused
on
summarizing
how
researchers
fully
thoroughly
combined
complex
modern
technology
ensure
usability
value
dressing,
photothermal-sensitive
dressings,
dressing
(pH-sensitive
ROS-sensitive
osmotic
pressure
dressings),
hemostatic
guiding
tissue
regeneration
microneedle
3D/4D
printing
Finally,
revolutionary
development
transform
existing
into
needs
soon
possible
have
carried
out
a
reasonable
meaningful
outlook.
