Pulmonary inhalation for disease treatment: Basic research and clinical translations

Materials Today Bio, Год журнала: 2024, Номер 25, С. 100966 - 100966

Опубликована: Янв. 22, 2024

Pulmonary drug delivery has the advantages of being rapid, efficient, and well-targeted, with few systemic side effects. In addition, it is non-invasive good patient compliance, making a highly promising mode. However, there have been limited studies on via pulmonary inhalation compared oral intravenous modes. This paper summarizes basic research clinical translation for treatment diseases provides insights into latest advances in delivery. The discusses processing methods delivery, carriers (with focus various types nanoparticles), devices, applications (e.g., COVID-19, inhaled vaccines, diagnosis diseases, diabetes mellitus) an updated summary recent advances. Furthermore, this describes progress lung expands use drugs other diseases.

Язык: Английский

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Pulmonary delivery nanomedicines towards circumventing physiological barriers: Strategies and characterization approaches

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 185, С. 114309 - 114309

Опубликована: Апрель 22, 2022

Язык: Английский

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Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery

Journal of Controlled Release, Год журнала: 2022, Номер 352, С. 970 - 993

Опубликована: Ноя. 16, 2022

Язык: Английский

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Mucus Penetration of Surface-Engineered Nanoparticles in Various pH Microenvironments

ACS Nano, Год журнала: 2023, Номер 17(3), С. 2813 - 2828

Опубликована: Янв. 31, 2023

The penetration behavior of nanoparticles in mucous depends on physicochemical properties the and mucus microenvironment, due to particle–mucin interactions presence mucin mesh space filtration effect. To date, it is still unclear how surface influence their behaviors various physiological pathophysiological conditions. In this study, we have prepared a comprehensive library amine-, carboxyl-, PEG-modified silica (SNPs) with controlled ligand densities. Using multiple particle tracking, studied mechanism responsible for these SNPs. It was found that PEG- amine-modified SNPs exhibited pH-independent immobilization under iso-density conditions, while carboxyl-modified enhanced movement only weakly alkaline mucus. Biophysical characterizations demonstrated amine- were trapped electrostatic hydrogen bonding mucin. contrast, high-density PEGylated formed brush conformation shields interactions. We further investigated property-dependent using murine airway distribution model. This study provides insights designing efficient transmucosal nanocarriers prevention treatment pulmonary diseases.

Язык: Английский

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Elucidating inhaled liposome surface charge on its interaction with biological barriers in the lung

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2022, Номер 172, С. 101 - 111

Опубликована: Фев. 9, 2022

Язык: Английский

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Protein adsorption determines pulmonary cell uptake of lipid-based nanoparticles

Journal of Colloid and Interface Science, Год журнала: 2023, Номер 641, С. 36 - 47

Опубликована: Март 11, 2023

The inhalable administration of lipid nanoparticles is an effective strategy for localised delivery therapeutics against various lung diseases. Of this, improved intracellular pharmaceuticals infectious disease and cancer management high significance. However, the influence nanoparticle composition structure on uptake in pulmonary cell lines, especially presence biologically relevant media poorly understood. Here, lamellar (liposomes) versus non-lamellar (cubosomes) macrophages epithelial cells was quantified bronchoalveolar lavage fluid (BALF), containing native protein surfactant molecules determined. Cubosome both strongly mediated by a percentage molecular function regulatory binding proteins present within corona. In contrast, corona did not liposomes cells. macrophages, rapid internalisation, followed exocytosis after 6 h incubation. These findings biological regulating mechanisms may guide future development optimal systems via route.

Язык: Английский

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Opportunities and Challenges for Inhalable Nanomedicine Formulations in Respiratory Diseases: A Review

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 1509 - 1538

Опубликована: Фев. 1, 2024

Abstract: Lungs experience frequent interactions with the external environment and have an abundant supply of blood; therefore, they are susceptible to invasion by pathogenic microorganisms tumor cells. However, limited pharmacokinetics conventional drugs in lungs poses a clinical challenge. The emergence different nano-formulations has been facilitated advancements nanotechnology. Inhaled nanomedicines exhibit better targeting prolonged therapeutic effects. Although great potential, still present several unknown risks. Herein, we review (1) physiological anatomy their biological barriers, (2) toxicology nanomaterial formulations lungs; (3) current nanomaterials that can be applied respiratory system related design strategies, (4) applications inhaled treating disorders, vaccine design, imaging detection based on characteristics nanomaterials. Finally, (5) analyze summarize challenges prospects for disease applications. We believe nanomaterials, particularly nano-formulations, excellent application diseases. emphasize simultaneous toxic side effects must considered during these emerging medicines. This study aims offer comprehensive guidelines valuable insights conducting research domain system. Keywords: nanoparticles, system, lungs, nanotechnology

Язык: Английский

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A PEG-assisted membrane coating to prepare biomimetic mesoporous silicon for PET/CT imaging of triple-negative breast cancer

International Journal of Pharmaceutics, Год журнала: 2024, Номер 652, С. 123764 - 123764

Опубликована: Янв. 2, 2024

Triple-negative breast cancer (TNBC) diagnosis remains challenging without expressing critical receptors. Cancer cell membrane (CCm) coating has been extensively studied for targeted diagnostics due to attractive features such as good biocompatibility and homotypic tumor-targeting. However, the present study found that widely used CCm approaches, extrusion, were not applicable functionalizing irregularly shaped nanoparticles (NPs), porous silicon (PSi). To tackle this challenge, we proposed a novel approach employs polyethylene glycol (PEG)-assisted coating, wherein PEG are respectively functionalized on PSi NPs through chemical conjugation physical absorption. Meanwhile, grafted with bisphosphonate (BP) molecules radiolabeling. Thanks chelating ability of BP tumor targeting PSi-based contrast agent (CCm-PEG-

Язык: Английский

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A Mucous Permeable Local Delivery Strategy Based on Manganese-Enhanced Bacterial Cuproptosis-like Death for Bacterial Pneumonia Treatment

ACS Nano, Год журнала: 2024, Номер 18(46), С. 31923 - 31940

Опубликована: Ноя. 7, 2024

Bacterial pneumonia is one of the most challenging global infectious diseases with high morbidity and mortality. Considering antibiotic abuse resistance bacterial biofilms, a variety metal-based materials have been developed. However, due to oxygen environment lungs, some aerobic infection bacteria tolerance ROS, based on ROS may not achieve good therapeutic effects. Inspired by sensitivity cuproptosis respiratory cells, we designed copper composite antibacterial nanoparticle found that it can effectively induce cuproptosis-like death in lungs. To address challenge

Язык: Английский

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Smart and Multi-Functional Magnetic Nanoparticles for Cancer Treatment Applications: Clinical Challenges and Future Prospects

Nanomaterials, Год журнала: 2022, Номер 12(20), С. 3567 - 3567

Опубликована: Окт. 12, 2022

Iron oxide nanoparticle (IONPs) have become a subject of interest in various biomedical fields due to their magnetism and biocompatibility. They can be utilized as heat mediators magnetic hyperthermia (MHT) or contrast media resonance imaging (MRI), ultrasound (US). In addition, high drug-loading capacity enabled them therapeutic agent transporters for malignancy treatment. Hence, smartening allows an intelligent controlled drug release (CDR) targeted delivery (TDD). Smart nanoparticles (SMNPs) overcome the impediments faced by classical chemo-treatment strategies, since they navigated via external internal stimuli. Recently, been synchronized with other modalities, e.g., MRI, MHT, US, dual/multimodal theranostic applications single platform. Herein, we provide overview attributes MNPs cancer application, fabrication procedures, surface coatings, targeting approaches, recent advancement SMNPs. Even though feature numerous privileges over chemotherapy agents, obstacles remain clinical usage. This review particular covers predicaments SMNPs future research scopes field theranostics.

Язык: Английский

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