Nanomaterials,
Год журнала:
2025,
Номер
15(3), С. 224 - 224
Опубликована: Янв. 30, 2025
In
this
work,
we
report
for
the
first
time
development
and
complex
characterization
of
new
bioceramics
based
on
hydroxyapatite
(HAp,
Ca10(PO4)6(OH)2).
On
other
hand,
lyophilization
process
was
used
in
research.
The
samples
were
obtained
by
a
modified
coprecipitation
method
dried
(lyophilized
(HApLF)
lyophilized
zinc-doped
(5ZnHApLF)).
Valuable
information
about
HApLF
5ZnHApLF
stability
through
nondestructive
ultrasound
measurements.
X-ray
diffraction
(XRD)
studies
revealed
phase
effects
incorporation
Zn
ions
into
HAp
structure.
chemical
composition
evaluated
energy
dispersive
analysis
(EDS)
photoelectron
spectroscopy
(XPS).
Information
functional
groups
present
using
Fourier
Transform
Infrared
Spectroscopy
(FTIR)
studies.
morphology
pellets
observed
scanning
electron
microscopy
(SEM).
surface
topography
studied
with
aid
atomic
force
(AFM).
Details
regarding
roughness
also
AFM
topographies
SEM
images.
A
complementary
study
carried
out
larger
Scanning
Acoustic
Microscope
(SAM).
SAM
to
analyze
5ZnHAp
pellets.
biological
properties
investigated
MG63
human
gingival
fibroblasts
(HGF-1)
cell
lines.
results
viability
assay
highlighted
that
both
exhibited
good
activity.
Moreover,
conducted
order
emphasize
HGF-1
cells
pellet’s
surface.
Both
images
depicted
pellets’
favored
attachment
cells.
Furthermore,
antimicrobial
against
Escherichia
coli
ATCC
25922,
Staphylococcus
aureus
25923,
Candida
albicans
10231.
assays
strong
activity
tested
microbial
strains.
suggested
show
great
potential
being
novel
materials
biomedical
applications.
Advances in Colloid and Interface Science,
Год журнала:
2023,
Номер
321, С. 103013 - 103013
Опубликована: Окт. 7, 2023
Hydroxyapatite
(HAp),
a
well-known
biomaterial,
has
witnessed
remarkable
evolution
over
the
years,
transforming
from
simple
biocompatible
substance
to
an
advanced
functional
material
with
wide
range
of
applications.
This
abstract
provides
overview
significant
advancements
in
field
HAp
and
its
journey
towards
becoming
multifunctional
material.
Initially
recognized
for
exceptional
biocompatibility
bioactivity,
gained
prominence
bone
tissue
engineering
dental
Its
ability
integrate
surrounding
tissues,
promote
cellular
adhesion,
facilitate
osseointegration
made
it
ideal
candidate
various
biomedical
implants
coatings.
As
understanding
grew,
researchers
explored
potential
beyond
traditional
biomaterial
With
advances
synthesis
engineering,
began
exhibit
unique
properties
that
extended
utility
other
disciplines.
Researchers
successfully
tailored
composition,
morphology,
surface
characteristics
HAp,
leading
enhanced
mechanical
strength,
controlled
drug
release
capabilities,
improved
biodegradability.
These
modifications
enabled
utilization
delivery
systems,
biosensors,
scaffolds,
regenerative
medicine
Moreover,
biomineralization
allowed
incorporation
ions
molecules
during
synthesis,
development
bioactive
coatings
composites
specific
therapeutic
functionalities.
functionalized
materials
have
demonstrated
promising
results
antimicrobial
coatings,
systems
growth
factors
agents,
even
as
catalysts
chemical
reactions.
In
recent
nanoparticles
nanostructured
emerged
focal
point
research
due
their
physicochemical
targeted
delivery,
imaging,
theranostic
The
manipulate
size,
shape,
chemistry
at
nanoscale
paved
way
innovative
approaches
personalized
therapies.
highlights
exploration
novel
methods,
modifications,
nanoengineering
techniques
expanded
horizon
applications,
enabling
integration
into
diverse
fields
ranging
biomedicine
catalysis.
Additionally,
this
manuscript
discusses
emerging
prospects
HAp-based
photocatalysis,
sensing,
energy
storage,
showcasing
realm
progresses,
future
holds
tremendous
revolutionize
medical
treatments
contribute
advancement
science
technology.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(17), С. 13157 - 13157
Опубликована: Авг. 24, 2023
Bone
tissue
engineering
has
attracted
great
interest
in
the
last
few
years,
as
frequency
of
tissue-damaging
or
degenerative
diseases
increased
exponentially.
To
obtain
an
ideal
treatment
solution,
researchers
have
focused
on
development
optimum
biomaterials
to
be
applied
for
enhancement
bioactivity
and
regeneration
process,
which
are
necessary
support
proper
healing
process
osseous
tissues.
In
this
regard,
hydroxyapatite
(HA)
been
most
widely
used
material
biomedical
field
due
its
biocompatibility
similarity
with
native
apatite
from
human
bone.
However,
HA
still
presents
some
deficiencies
related
mechanical
properties,
essential
load-bearing
applications.
Bioactivity
is
another
vital
property
further
improve
antibacterial
activity.
These
drawbacks
can
solved
by
doping
trace
elements,
adapting
properties
material,
and,
finally,
sustaining
bone
without
occurrence
implant
failure.
Considering
these
aspects,
review,
we
presented
general
information
about
synthesis
methods,
applications,
necessity
addition
ions
into
structure.
Also,
their
influence
HA,
well
latest
applications
doped
materials
field.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(9), С. 4490 - 4606
Опубликована: Янв. 1, 2024
This
review
discusses
recent
advances,
challenges,
future
research
directions
and
perspectives
in
biomineralized
tissues,
providing
in-depth
insights
into
derived
guidelines
for
design
preparation
of
high-performance
biomimetic
materials.
ACS Applied Bio Materials,
Год журнала:
2023,
Номер
6(7), С. 2591 - 2613
Опубликована: Июнь 15, 2023
Cardiovascular
disease
is
a
global
health
threat,
and
detecting
cardiac
biomarkers
essential
for
early-stage
diagnosis
personalized
treatment.
Traditional
approaches
have
limitations,
but
optical
nanobiosensors
offer
rapid,
highly
selective,
sensitive
detection.
Optical
generate
biosignals
that
transfer
light
signals
while
analytes
bind
with
the
bioreceptors.
advantages
such
as
ease
of
monitoring,
low
cost,
wide
detection
range,
high
sensitivity
without
any
interference.
An
nanobiosensor
platform
promising
approach
point-of-care
biomarker
limit.
This
review
mainly
focuses
on
cardiovascular
based
various
been
reported
during
last
five
years,
we
categorized
them
signal
readouts.
A
detailed
discussion
classification
biomarkers,
design
strategies
biosensors,
types
optically
active
nanomaterials,
bioreceptors,
functionalization
techniques,
assay
types,
sensing
mechanisms
presented.
Then,
summarize
signaling
readout-based
systems
biomarkers.
Finally,
conclude
recent
development
testing
(PoCT)
used
in
readout
techniques.
Advanced Materials,
Год журнала:
2023,
Номер
36(2)
Опубликована: Ноя. 17, 2023
Abstract
Titanium
implants
are
widely
used
;
however,
implantation
occasionally
fails
due
to
infections
during
the
surgery
or
poor
osseointegration
after
surgery.
To
solve
problem,
an
intelligent
functional
surface
on
titanium
implant
that
can
sequentially
eradicate
bacteria
biofilm
at
initial
period
and
promote
late
of
post‐surgery
time
is
designed.
Such
surfaces
be
excited
by
near
infrared
light
(NIR),
with
rare
earth
nanoparticles
upconvert
NIR
visible
range
adsorb
Au
nanoparticles,
supported
oxide
porous
film
implants.
Under
irradiation,
converts
energy
phonon
hot
electrons
lattice
vibrations,
while
former
flows
directly
contact
substance
partially
reacts
surrounding
generate
reactive
oxygen
species,
latter
leads
local
temperature
increase.
The
microbes
eradicated
treatment
in
vitro
vivo.
Additionally,
exhibits
superior
biocompatibility
for
cell
survival,
adhesion,
proliferation,
osteogenic
differentiation,
which
provides
foundation
osseointegration.
In
vivo
experiments
demonstrate
also
promoted.
This
work
thus
demonstrates
NIR‐generated
biofilms
regulate
process,
providing
new
solutions
fabricate
efficient
surfaces.
ACS Omega,
Год журнала:
2025,
Номер
10(6), С. 5351 - 5361
Опубликована: Фев. 3, 2025
Photocatalysis
heterogeneous
is
an
essential
method
for
water
treatment.
In
this
study,
a
novel
photocatalytic
erbium-doped
hydroxyapatite-decorated
titanium
dioxide
(TiO2@Er-Hap)
was
obtained
using
the
sol-gel
and
applied
to
remove
ciprofloxacin
(CIP)
drug
methylene
blue
(MB)
dye
contaminants.
The
sample's
structural,
physical,
morphological,
properties
were
investigated.
X-ray
diffraction
(XRD)
confirmed
presence
of
anatase
phase
in
TiO2@Er-Hap.
oxide
nanoparticles
deposited
on
Hap
surface,
proposed
material
presented
band
gap
energy
3.33
eV.
Furthermore,
TiO2@Er-Hap
larger
surface
area
when
compared
with
not
decorated
oxide.
tests
performed
under
ultraviolet
(UV)
irradiation
showed
that
removed
MB
(100%)
CIP
(71.16%),
despite
low
mineralization
evidenced
TOC
analysis.
irradiated
pollutant
solution
after
photocatalysis
process
nontoxic,
as
observed
ecotoxic
test,
indicating
worked.
Inhibitor
•OH
radicals
main
species
involved
performed.
demonstrated
activity
even
five
consecutive
cycles
use.
Finally,
results
suggest
suitable
candidate
decontamination
via
processes.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Год журнала:
2023,
Номер
140, С. 105722 - 105722
