Polymers for Advanced Technologies,
Год журнала:
2024,
Номер
35(5)
Опубликована: Май 1, 2024
Abstract
The
development
of
electrospun
tissue
engineering
scaffolds
using
silk
fibroin
and
polycaprolactone
(PCL)
has
been
reported.
challenge
in
this
system
is
the
design
a
suitable
solvent
with
high
stability.
In
study,
mat
was
PCL‐fibroin
fibers
an
emulsion
consisting
PCL
blend
polyethylene
oxide
(PEO).
effects
different
concentrations
PEO
ratios
formic
acid:
distilled
water
(FA:DW,
for
PEO)
chloroform:
acid
(Chl:FA,
PCL)
were
studied.
FA:DW
Chl:FA
70:30
proved
to
make
optimized
stable
system.
addition,
by
controlling
absorption
mat,
we
its
weight
loss
maintained
integrity
up
14
days.
Also,
mechanical
cell
attachment
properties
as
expected.
Chorioallantoic
membrane
(CAM)
assay
exhibited
potential
mats
induce
angiogenesis.
Furthermore,
subcutaneous
implantation
mouse
model
elicited
no
significant
inflammatory
response.
This
study
provides
simple
promising
electrospinning
fabrication
applications.
OBM Neurobiology,
Год журнала:
2025,
Номер
09(01), С. 1 - 20
Опубликована: Янв. 20, 2025
Regenerating
injured
nerves
is
difficult
because
they
have
little
spontaneous
regeneration
potential.
Advances
in
tissue
engineering
and
regenerative
medicine
emphasized
the
possibility
of
biomaterial-based
methods
for
nerve
healing.
Natural
protein-based
biomaterials
benefits
over
synthetic
ones,
such
as
biocompatibility,
non-immunogenicity,
biodegradability.
Silk
fibroin,
generated
from
mulberry
non-mulberry
silkworms,
especially
promising
its
abundance,
simplicity
processing
into
nerve-like
structures,
adjustable
biodegradability,
mechanical
robustness.
Furthermore,
silk
fibroin
contains
cell-affinitive
RGD
tripeptide,
which
enhances
ability
to
repair
nerves.
Studies
using
(SF)--based
conduits
demonstrated
rates
up
80–90%
compared
autografts,
remain
clinical
gold
standard.
SF
exhibit
outstanding
properties,
with
tensile
strengths
300
MPa
elastic
moduli
between
kPa-MPa
range,
closely
mimic
native
ensure
durability
dynamic
environments.
This
review
explores
diverse
types
silkworm
(SSF)
their
applications
Peripheral
Nerve
Repair
(PNR).
It
discusses
integration
SSF
other
biopolymers
polymers,
highlighting
advancements
guidance
channels
incorporating
electro-conductive
materials
enhance
rates.
The
literature
search
was
primarily
conducted
Web
Science
database,
employing
relevant
keyword
combinations
“silk
+
repair,”
peripheral
electrical
stimulation.”
As
this
focuses
on
silk-based
biomaterials,
studies
involving
spider
or
recombinant
were
excluded.
period
considered
began
earliest
studies,
an
emphasis
more
recent
November
2024
capture
latest
developments
field.
Identified
categorized
based
biomaterial
composition,
including
pure
biopolymer
binary
composites,
silk-hybrid
composites.
Key
findings
synthesized
highlight
progress,
challenges,
future
directions
applying
fibroin-based
scaffolds
stimulation
technologies
repair.
provide
insights
potential
SSF-based
propose
developing
advanced
strategies.
