Extracellular matrix mimicking dynamic interpenetrating network hydrogel for skin tissue engineering

Chemical Engineering Journal, Год журнала: 2023, Номер 457, С. 141362 - 141362

Опубликована: Янв. 7, 2023

Язык: Английский

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A Multifunctional, Tough, Stretchable, and Transparent Curcumin Hydrogel with Potent Antimicrobial, Antioxidative, Anti-inflammatory, and Angiogenesis Capabilities for Diabetic Wound Healing

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(8), С. 9749 - 9767

Опубликована: Фев. 15, 2024

The treatment of diabetic chronic wounds is still faced with great challenges, mainly due to wound infection, excessive inflammation, and peripheral vascular disease in the area. Therefore, it importance develop a novel multifunctional hydrogel high efficiency accelerate healing. Curcumin (Cur), Chinese herbal, has shown potential enhancing healing because its immunomodulatory pro-angiogenic properties. However, low aqueous solubility, poor bioavailability, chemical instability have limited clinical applications. To address these current bottlenecks, poly(vinyl alcohol) (PVA)–chitosan (CS)/sodium alginate (SA)–Cur (PCSA) hydrogels were prepared for first time, they demonstrated all above intriguing performances by Michael addition reaction CS Cur. PCSA show multiple dynamic bonds, which possess strong mechanical properties (tensile stress: ∼0.980 MPa; toughness: ∼258.45 kJ/m3; compressive strength: ∼7.38 MPa at strain 80%). These provided an optimal microenvironment cell migration proliferation also promoted growth blood vessels, leading early angiogenesis. Importantly, experimental results that can effectively transform pro-inflammatory M1 macrophages into anti-inflammatory M2 without need additional ingredients vitro. Benefiting from characteristics, full-thickness rat model via ROS-scavenging, downregulation IL-1β, upregulation CD31 expression, resulting angiogenesis collagen deposition. This strategy not only provides simple safe Cur-based but highlights significant development high-performance biomaterials promoting using traditional medicine.

Язык: Английский

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Bioengineered skin organoids: from development to applications

Military Medical Research, Год журнала: 2023, Номер 10(1)

Опубликована: Авг. 22, 2023

Abstract Significant advancements have been made in recent years the development of highly sophisticated skin organoids. Serving as three-dimensional models that mimic human skin, these organoids evolved into complex structures and are increasingly recognized effective alternatives to traditional culture due their ability overcome limitations two-dimensional systems ethical concerns. The inherent plasticity allows for construction physiological pathological models, enabling study dynamic changes. This review provides an overview pivotal work progression from 3D layered epidermis cyst-like with appendages. Furthermore, it highlights latest organoid facilitated by state-of-the-art engineering techniques, such printing microfluidic devices. also summarizes discusses diverse applications developmental biology, disease modelling, regenerative medicine, personalized while considering prospects limitations.

Язык: Английский

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Marine Collagen-Based Bioink for 3D Bioprinting of a Bilayered Skin Model

Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1331 - 1331

Опубликована: Апрель 24, 2023

Marine organisms (i.e., fish, jellyfish, sponges or seaweeds) represent an abundant and eco-friendly source of collagen. collagen, compared to mammalian can be easily extracted, is water-soluble, avoids transmissible diseases owns anti-microbial activities. Recent studies have reported marine collagen as a suitable biomaterial for skin tissue regeneration. The aim this work was investigate, the first time, from basa fish development bioink extrusion 3D bioprinting bilayered model. bioinks were obtained by mixing semi-crosslinked alginate with 10 20 mg/mL characterised evaluating printability in terms homogeneity, spreading ratio, shape fidelity rheological properties. Morphology, degradation rate, swelling properties antibacterial activity also evaluated. alginate-based containing selected skin-like constructs human fibroblasts keratinocytes. bioprinted showed homogeneous distribution viable proliferating cells at days 1, 7 14 culture evaluated qualitative (live/dead) (XTT) assays, histological (H&E) gene expression analysis. In conclusion, successfully used formulate bioprinting. particular, printed structures able support keratinocytes viability proliferation.

Язык: Английский

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3D Printing‐Based Hydrogel Dressings for Wound Healing

Advanced Science, Год журнала: 2024, Номер 11(47)

Опубликована: Ноя. 18, 2024

Abstract Skin wounds have become an important issue that affects human health and burdens global medical care. Hydrogel materials similar to the natural extracellular matrix (ECM) are one of best candidates for ideal wound dressings most feasible choices printing inks. Distinct from hydrogels made by traditional technologies, which lack bionic mechanical properties, 3D can promptly accurately create with complex bioactive structures potential promote tissue regeneration healing. Herein, a comprehensive review multi‐functional printing‐based hydrogel healing is presented. The first summarizes techniques dressings, including photo‐curing, extrusion, inkjet, laser‐assisted printing. Then, properties design approaches series bioinks composed natural, synthetic, composite polymers described. Thereafter, application in variety environments discussed depth, hemostasis, anti‐inflammation, antibacterial, skin appendage regeneration, intelligent monitoring, machine learning‐assisted therapy. Finally, challenges prospects

Язык: Английский

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Recent Advances in Environment-Friendly Polyurethanes from Polyols Recovered from the Recycling and Renewable Resources: A Review

Polymers, Год журнала: 2024, Номер 16(13), С. 1889 - 1889

Опубликована: Июль 2, 2024

Polyurethane (PU) is among the most universal polymers and has been extensively applied in many fields, such as construction, machinery, furniture, clothing, textile, packaging biomedicine. Traditionally, main starting materials for PU, polyols deeply depend on petroleum stock. From perspective of recycling environmental friendliness, advanced PU synthesis, using diversified resources feedstocks, aims to develop versatile products with excellent properties achieve transformation from a fossil fuel-driven energy economy renewable sustainable ones. This review focuses recent development synthesis modification by extracting value-added monomers waste natural bio-based polymers, recycled polymers: polyethylene terephthalate (PET), polycarbonate (PC); biomaterials: vegetable oil, lignin, cashew nut shell liquid plant straw; biomacromolecules: polysaccharides protein. To design these polyurethane formulations, it essential understand structure-property relationships polyols. In word, this bottom-up path provides material approach printing packaging, well biomedical, building wearable electronics applications.

Язык: Английский

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Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration

Exploration, Год журнала: 2024, Номер 4(5)

Опубликована: Апрель 17, 2024

Abstract Scaffold‐based tissue engineering provides an efficient approach for repairing uterine defects and restoring fertility. In the current study, a novel trilayer scaffold with high similarity to in structure was designed fabricated via 4D printing, electrospinning 3D bioprinting regeneration. Highly stretchable poly( l ‐lactide‐ co ‐trimethylene carbonate) (PLLA‐ ‐TMC, “PTMC” short)/thermoplastic polyurethane (TPU) polymer blend scaffolds were firstly made printing. To improve biocompatibility, porous poly(lactic acid‐ ‐glycolic acid) (PLGA)/gelatin methacryloyl (GelMA) fibers incorporated polydopamine (PDA) particles produced on PTMC/TPU electrospinning. Importantly, estradiol (E2) encapsulated PDA particles. The bilayer thus could provide controlled sustained release of E2. Subsequently, bone marrow derived mesenchymal stem cells (BMSCs) mixed gelatin (GelMA)‐based inks formulated bioinks used fabricate cell‐laden hydrogel layer bioprinting, forming ultimately biomimicking formed exhibited shape morphing ability by transforming from planar tubular structures when immersed culture medium at 37°C. under development would new insights

Язык: Английский

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3D-printed biodegradable polymer scaffolds for tissue engineering: An overview, current stage and future perspectives

Next Materials, Год журнала: 2025, Номер 8, С. 100647 - 100647

Опубликована: Апрель 16, 2025

Язык: Английский

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Porous gradient hydrogel promotes skin regeneration by angiogenesis

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 671, С. 312 - 324

Опубликована: Май 17, 2024

Язык: Английский

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A sustainable strategy for generating highly stable human skin equivalents based on fish collagen

Biomaterials Advances, Год журнала: 2024, Номер 158, С. 213780 - 213780

Опубликована: Янв. 24, 2024

Язык: Английский

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