The Chemical Record,
Год журнала:
2023,
Номер
23(5)
Опубликована: Апрель 3, 2023
Abstract
Rhodium
(Rh)
is
a
non‐toxic
transition
metal
used
as
various
nanomaterials
with
unique
structures
and
properties.
Rh‐based
nanozymes
can
mimic
the
activities
of
natural
enzymes,
overcome
limitation
application
scope
interact
biological
microenvironments
to
play
variety
functions.
be
synthesized
in
ways,
different
modification
regulation
methods
also
enable
users
control
catalytic
performance
by
adjusting
enzyme
active
sites.
The
construction
has
attracted
great
interest
biomedical
field
impacted
industry
other
areas.
This
paper
reviews
typical
synthesis
strategies,
properties,
applications,
challenges,
prospects
nanozymes.
Next,
features
are
emphasized,
including
adjustable
enzyme‐like
activity,
stability,
biocompatibility.
In
addition,
we
discuss
biosensors
detection,
therapy,
industrial
applications.
Finally,
future
challenges
proposed.
ACS Nano,
Год журнала:
2024,
Номер
18(44), С. 30345 - 30359
Опубликована: Окт. 21, 2024
Lactate-enriched
tumor
microenvironment
(TME)
fosters
an
immunosuppressive
milieu
to
hamper
the
functionality
of
tumor-associated
macrophages
(TAMs).
However,
tackling
effects
wrought
by
lactate
accumulation
is
still
a
big
challenge.
Herein,
we
construct
dual
enzyme-driven
cascade
reaction
platform
(ILH)
with
TME
modulation
for
photoacoustic
(PA)
imaging-guided
catalytic
therapy
and
immune
activation.
The
ILH
composed
iridium
(Ir)
metallene
nanozyme,
oxidase
(LOx),
hyaluronic
acid
(HA).
combination
Ir
nanozyme
LOx
can
not
only
efficiently
consume
reverse
into
immunoreactive
one
promoting
polarization
TAMs
from
M2
M1
phenotype,
thus
enhancing
antitumor
defense,
but
also
alleviate
hypoxia
as
well
induce
strong
oxidative
stress,
triggering
immunogenic
cell
death
(ICD)
activating
immunity.
Furthermore,
photothermal
performance
strengthen
ability
endow
PA
response.
Based
on
changes
in
signals
endogenous
molecules,
three-dimensional
multispectral
imaging
was
utilized
track
process
vivo.
This
work
provides
nanoplatform
activation
regulating
TME.
The Chemical Record,
Год журнала:
2023,
Номер
23(5)
Опубликована: Апрель 3, 2023
Abstract
Rhodium
(Rh)
is
a
non‐toxic
transition
metal
used
as
various
nanomaterials
with
unique
structures
and
properties.
Rh‐based
nanozymes
can
mimic
the
activities
of
natural
enzymes,
overcome
limitation
application
scope
interact
biological
microenvironments
to
play
variety
functions.
be
synthesized
in
ways,
different
modification
regulation
methods
also
enable
users
control
catalytic
performance
by
adjusting
enzyme
active
sites.
The
construction
has
attracted
great
interest
biomedical
field
impacted
industry
other
areas.
This
paper
reviews
typical
synthesis
strategies,
properties,
applications,
challenges,
prospects
nanozymes.
Next,
features
are
emphasized,
including
adjustable
enzyme‐like
activity,
stability,
biocompatibility.
In
addition,
we
discuss
biosensors
detection,
therapy,
industrial
applications.
Finally,
future
challenges
proposed.
