Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Effectively
managing
infected
diabetic
wounds
involves
the
elimination
of
bacteria,
neutralization
reactive
oxygen
species
(ROS),
suppression
inflammation,
and
induction
angiogenesis.
This
study
describes
development
a
multifunctional
hyaluronic
acid
(HA)-based
microgel
system
capable
serving
as
either
an
injectable
wet
or
dry
microspheres
(MSs).
After
initially
engineering
Fe2+/tea
polyphenol
(TP)
metal-polyphenol
network
(MPN)-functionalized
HAMA
MS,
these
particles
were
found
to
suppress
inflammation
facilitate
ROS
scavenging.
A
deferoxamine
(DFO)-loaded
zinc-based
metal-organic
framework
(ZIF-8@DFO)
was
then
coated
using
phenylboronic
(PBA)-functionalized
ε-polylysine
(PPL)
produce
PPZD
nanoparticles
with
antibacterial
pro-angiogenic
properties.
The
dynamic
loading
into
MPN-functionalized
MS
(MMS)
via
boron
ester
bonds
yielded
pH/ROS-responsive
(MMS@PPZD).
PPL
coating
endowed
prepared
materials
antimicrobial
properties
while
mitigating
cytotoxic
effects
resulting
from
rapid
release
Zn2+
DFO
in
acidic
micro-environments.
showed
superior
biocompatibility
phased
intervention
activities
aligned
various
stages
wound
healing
process
vitro
vivo.
Specifically,
under
conditions,
sequentially
released
TP,
PL,
Zn2+,
DFO,
enabling
effective
scavenging,
suppressing
exhibiting
activity,
inducing
Overall,
this
environmentally-responsive,
multifunctional,
versatile
offers
significant
promise
for
management.
Osteoarthritis
(OA)
is
a
chronic
and
complicated
degenerative
disease
for
which
there
currently
no
effective
treatment.
Isoorientin
(ISO)
natural
plant
extract
that
has
antioxidant
activity
could
be
used
to
treat
OA.
However,
due
lack
of
research,
it
not
been
widely
used.
In
this
study,
we
investigated
the
protective
effects
molecular
mechanisms
ISO
on
H2O2-induced
chondrocytes,
cell
model
Based
RNA-seq
bioinformatics,
discovered
significantly
increased
chondrocytes
induced
by
H2O2,
was
associated
with
apoptosis
oxidative
stress.
Furthermore,
combination
H2O2
reduced
restored
mitochondrial
membrane
potential
(MMP),
may
achieved
inhibiting
mitogen-activated
protein
kinase
(MAPK)
signaling
pathways.
Moreover,
superoxide
dismutase
(SOD),
heme
oxygenase
1
(HO-1)
quinone
oxidoreductase
(NQO-1)
malondialdehyde
(MDA)
levels.
Finally,
inhibited
intracellular
reactive
oxygen
species
(ROS)
in
activating
nuclear
factor
erythroid
2-related
2
(Nrf2)
phosphatidylinositol
3
kinase/protein
B
(PI3K/Akt)
This
study
establishes
theoretical
framework
ISO's
ability
inhibit
OA
vitro
models.
The Analyst,
Год журнала:
2023,
Номер
149(3), С. 614 - 637
Опубликована: Ноя. 28, 2023
Numerous
innovative
nanoparticle
formulations
of
drugs
and
biologics,
named
nano-formulations,
have
been
developed
in
the
last
two
decades.
However,
methods
for
their
scaled-up
production
are
still
lagging,
as
amount
needed
large
animal
tests
clinical
trials
is
typically
orders
magnitude
larger.
This
manufacturing
challenge
poses
a
critical
barrier
to
successfully
translating
various
nano-formulations.
review
focuses
on
how
microfluidics
technology
has
become
powerful
tool
overcome
this
by
synthesizing
nano-formulations
with
improved
particle
properties
product
purity
quantities.
microfluidic-based
enabled
microfluidic
mixing,
which
capable
precise
continuous
control
synthesis
We
further
discuss
specific
applications
hydrodynamic
flow
focusing,
staggered
herringbone
micromixer,
T-junction
mixer,
micro-droplet
generator,
glass
capillary
types
polymeric,
lipid,
inorganic,
nanocrystals.
Various
separation
purification
enhance
reviewed,
including
acoustofluidics,
hydrodynamics,
dielectrophoresis.
challenges
being
used
broader
research
industrial
communities.
also
provide
future
outlooks
its
enormous
potential
decentralized
approach
ACS Materials Letters,
Год журнала:
2024,
Номер
unknown, С. 3862 - 3882
Опубликована: Июль 24, 2024
Osteoarthritis
(OA)
is
a
chronic
condition
characterized
by
degeneration
of
the
articular
cartilage
and
subsequent
bone
hyperplasia.
With
increasing
prevalence
driven
factors
such
as
aging
obesity,
OA
poses
growing
health
economic
burden.
Current
treatments,
including
NSAIDs
corticosteroid
injections,
offer
limited
efficacy
often
result
in
adverse
effects,
highlighting
urgent
need
for
novel
therapeutic
approaches.
Emerging
research
has
identified
hydrogel
microspheres
promising
solution
management.
These
microspheres,
with
their
tunable
physicochemical
properties
biocompatibility,
provide
conducive
environment
regeneration
sustained
drug
delivery.
Unlike
bulk
hydrogels,
enhanced
injectability,
uniform
distribution,
reduced
tissue
damage.
This
review
discusses
recent
advancements
microsphere
technology,
focusing
on
fabrication,
unique
mechanisms,
applications
OA.
Additionally,
we
address
challenges
future
directions
clinical
translation,
aim
to
optimize
treatment.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Effectively
managing
infected
diabetic
wounds
involves
the
elimination
of
bacteria,
neutralization
reactive
oxygen
species
(ROS),
suppression
inflammation,
and
induction
angiogenesis.
This
study
describes
development
a
multifunctional
hyaluronic
acid
(HA)-based
microgel
system
capable
serving
as
either
an
injectable
wet
or
dry
microspheres
(MSs).
After
initially
engineering
Fe2+/tea
polyphenol
(TP)
metal-polyphenol
network
(MPN)-functionalized
HAMA
MS,
these
particles
were
found
to
suppress
inflammation
facilitate
ROS
scavenging.
A
deferoxamine
(DFO)-loaded
zinc-based
metal-organic
framework
(ZIF-8@DFO)
was
then
coated
using
phenylboronic
(PBA)-functionalized
ε-polylysine
(PPL)
produce
PPZD
nanoparticles
with
antibacterial
pro-angiogenic
properties.
The
dynamic
loading
into
MPN-functionalized
MS
(MMS)
via
boron
ester
bonds
yielded
pH/ROS-responsive
(MMS@PPZD).
PPL
coating
endowed
prepared
materials
antimicrobial
properties
while
mitigating
cytotoxic
effects
resulting
from
rapid
release
Zn2+
DFO
in
acidic
micro-environments.
showed
superior
biocompatibility
phased
intervention
activities
aligned
various
stages
wound
healing
process
vitro
vivo.
Specifically,
under
conditions,
sequentially
released
TP,
PL,
Zn2+,
DFO,
enabling
effective
scavenging,
suppressing
exhibiting
activity,
inducing
Overall,
this
environmentally-responsive,
multifunctional,
versatile
offers
significant
promise
for
management.
