A smart drug delivery microgel system with phased intervention capabilities and dual physical state of use promotes healing of diabetic infected wounds DOI
Fei Ma, Yuheng Liu, Yu Wang

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Effectively managing infected diabetic wounds involves the elimination of bacteria, neutralization reactive oxygen species (ROS), suppression inflammation, and induction angiogenesis. This study describes development a multifunctional hyaluronic acid (HA)-based microgel system capable serving as either an injectable wet or dry microspheres (MSs). After initially engineering Fe2+/tea polyphenol (TP) metal-polyphenol network (MPN)-functionalized HAMA MS, these particles were found to suppress inflammation facilitate ROS scavenging. A deferoxamine (DFO)-loaded zinc-based metal-organic framework (ZIF-8@DFO) was then coated using phenylboronic (PBA)-functionalized ε-polylysine (PPL) produce PPZD nanoparticles with antibacterial pro-angiogenic properties. The dynamic loading into MPN-functionalized MS (MMS) via boron ester bonds yielded pH/ROS-responsive (MMS@PPZD). PPL coating endowed prepared materials antimicrobial properties while mitigating cytotoxic effects resulting from rapid release Zn2+ DFO in acidic micro-environments. showed superior biocompatibility phased intervention activities aligned various stages wound healing process vitro vivo. Specifically, under conditions, sequentially released TP, PL, Zn2+, DFO, enabling effective scavenging, suppressing exhibiting activity, inducing Overall, this environmentally-responsive, multifunctional, versatile offers significant promise for management.

Язык: Английский

Isoorientin ameliorates H2O2-induced apoptosis and oxidative stress in chondrocytes by regulating MAPK and PI3K/Akt pathways DOI Creative Commons

Tiehan Cui,

Yun Lan, Yu‐Ying Lu

и другие.

Aging, Год журнала: 2023, Номер unknown

Опубликована: Июнь 5, 2023

Osteoarthritis (OA) is a chronic and complicated degenerative disease for which there currently no effective treatment. Isoorientin (ISO) natural plant extract that has antioxidant activity could be used to treat OA. However, due lack of research, it not been widely used. In this study, we investigated the protective effects molecular mechanisms ISO on H2O2-induced chondrocytes, cell model Based RNA-seq bioinformatics, discovered significantly increased chondrocytes induced by H2O2, was associated with apoptosis oxidative stress. Furthermore, combination H2O2 reduced restored mitochondrial membrane potential (MMP), may achieved inhibiting mitogen-activated protein kinase (MAPK) signaling pathways. Moreover, superoxide dismutase (SOD), heme oxygenase 1 (HO-1) quinone oxidoreductase (NQO-1) malondialdehyde (MDA) levels. Finally, inhibited intracellular reactive oxygen species (ROS) in activating nuclear factor erythroid 2-related 2 (Nrf2) phosphatidylinositol 3 kinase/protein B (PI3K/Akt) This study establishes theoretical framework ISO's ability inhibit OA vitro models.

Язык: Английский

Процитировано

13

Advanced manufacturing of nanoparticle formulations of drugs and biologics using microfluidics DOI
Yingnan Shen, Hogyeong Gwak, Bumsoo Han

и другие.

The Analyst, Год журнала: 2023, Номер 149(3), С. 614 - 637

Опубликована: Ноя. 28, 2023

Numerous innovative nanoparticle formulations of drugs and biologics, named nano-formulations, have been developed in the last two decades. However, methods for their scaled-up production are still lagging, as amount needed large animal tests clinical trials is typically orders magnitude larger. This manufacturing challenge poses a critical barrier to successfully translating various nano-formulations. review focuses on how microfluidics technology has become powerful tool overcome this by synthesizing nano-formulations with improved particle properties product purity quantities. microfluidic-based enabled microfluidic mixing, which capable precise continuous control synthesis We further discuss specific applications hydrodynamic flow focusing, staggered herringbone micromixer, T-junction mixer, micro-droplet generator, glass capillary types polymeric, lipid, inorganic, nanocrystals. Various separation purification enhance reviewed, including acoustofluidics, hydrodynamics, dielectrophoresis. challenges being used broader research industrial communities. also provide future outlooks its enormous potential decentralized approach

Язык: Английский

Процитировано

10

Transforming Osteoarthritis Treatment: Embracing Hydrogel Microspheres DOI
Jianan Chen, Xinfeng Zhou,

Yantong Li

и другие.

ACS Materials Letters, Год журнала: 2024, Номер unknown, С. 3862 - 3882

Опубликована: Июль 24, 2024

Osteoarthritis (OA) is a chronic condition characterized by degeneration of the articular cartilage and subsequent bone hyperplasia. With increasing prevalence driven factors such as aging obesity, OA poses growing health economic burden. Current treatments, including NSAIDs corticosteroid injections, offer limited efficacy often result in adverse effects, highlighting urgent need for novel therapeutic approaches. Emerging research has identified hydrogel microspheres promising solution management. These microspheres, with their tunable physicochemical properties biocompatibility, provide conducive environment regeneration sustained drug delivery. Unlike bulk hydrogels, enhanced injectability, uniform distribution, reduced tissue damage. This review discusses recent advancements microsphere technology, focusing on fabrication, unique mechanisms, applications OA. Additionally, we address challenges future directions clinical translation, aim to optimize treatment.

Язык: Английский

Процитировано

3

Three-dimensional gas-foamed scaffolds decorated with metal phenolic networks for cartilage regeneration DOI Creative Commons
Yujie Chen,

Wei Xu,

Zhen Pan

и другие.

Materials Today Bio, Год журнала: 2024, Номер 29, С. 101249 - 101249

Опубликована: Сен. 14, 2024

Язык: Английский

Процитировано

3

A smart drug delivery microgel system with phased intervention capabilities and dual physical state of use promotes healing of diabetic infected wounds DOI
Fei Ma, Yuheng Liu, Yu Wang

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Effectively managing infected diabetic wounds involves the elimination of bacteria, neutralization reactive oxygen species (ROS), suppression inflammation, and induction angiogenesis. This study describes development a multifunctional hyaluronic acid (HA)-based microgel system capable serving as either an injectable wet or dry microspheres (MSs). After initially engineering Fe2+/tea polyphenol (TP) metal-polyphenol network (MPN)-functionalized HAMA MS, these particles were found to suppress inflammation facilitate ROS scavenging. A deferoxamine (DFO)-loaded zinc-based metal-organic framework (ZIF-8@DFO) was then coated using phenylboronic (PBA)-functionalized ε-polylysine (PPL) produce PPZD nanoparticles with antibacterial pro-angiogenic properties. The dynamic loading into MPN-functionalized MS (MMS) via boron ester bonds yielded pH/ROS-responsive (MMS@PPZD). PPL coating endowed prepared materials antimicrobial properties while mitigating cytotoxic effects resulting from rapid release Zn2+ DFO in acidic micro-environments. showed superior biocompatibility phased intervention activities aligned various stages wound healing process vitro vivo. Specifically, under conditions, sequentially released TP, PL, Zn2+, DFO, enabling effective scavenging, suppressing exhibiting activity, inducing Overall, this environmentally-responsive, multifunctional, versatile offers significant promise for management.

Язык: Английский

Процитировано

0