Drug Design Development and Therapy,
Год журнала:
2024,
Номер
Volume 18, С. 6115 - 6132
Опубликована: Дек. 1, 2024
Ciprofol
is
a
novel
intravenous
anesthetic
that
has
been
increasingly
used
in
clinical
anesthesia
and
sedation.
Studies
suggested
ciprofol
reduced
oxidative
stress
inflammatory
responses
to
alleviate
cerebral
ischemia/reperfusion
(I/R)
injury,
but
whether
protects
the
heart
against
I/R
injury
mechanisms
are
unknown.
Herein,
we
assessed
effects
of
on
ferroptosis
during
myocardial
injury.
European Heart Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 21, 2025
Ferroptosis,
an
iron-dependent
form
of
regulated
cell
death,
has
been
identified
as
a
key
factor
in
the
pathogenesis
and
progression
various
cardiovascular
diseases
(CVDs).
The
molecular
basis
ferroptosis
involves
lipid
peroxidation,
iron
dysregulation,
antioxidant
pathways.
Accumulating
evidence
suggests
that
is
associated
with
CVDs,
including
atherosclerosis,
myocardial
ischaemia-reperfusion
injury,
cardiac
hypertrophy,
diverse
cardiomyopathies.
In
addition
to
inhibitors,
several
novel
ferroptosis-targeting
therapies
have
emerged,
new
uses
for
existing
drugs,
plant-derived
compounds,
targeted
drug
delivery.
This
review
synthesizes
current
knowledge,
identifies
research
gaps
summarize
complex
regulatory
mechanisms
ferroptosis,
provides
overview
its
functions
CVDs.
innovative
therapeutic
strategies
targeting
may
lead
paradigm
change
treatment
Nanomedicine,
Год журнала:
2024,
Номер
unknown, С. 1 - 21
Опубликована: Сен. 24, 2024
This
study
aimed
to
construct
an
ischemic
cardiomyocyte-targeted
and
ROS-responsive
drug
release
system
reduce
myocardial
ischemia-reperfusion
injury
(MI/RI).
Drug Design Development and Therapy,
Год журнала:
2024,
Номер
Volume 18, С. 6115 - 6132
Опубликована: Дек. 1, 2024
Ciprofol
is
a
novel
intravenous
anesthetic
that
has
been
increasingly
used
in
clinical
anesthesia
and
sedation.
Studies
suggested
ciprofol
reduced
oxidative
stress
inflammatory
responses
to
alleviate
cerebral
ischemia/reperfusion
(I/R)
injury,
but
whether
protects
the
heart
against
I/R
injury
mechanisms
are
unknown.
Herein,
we
assessed
effects
of
on
ferroptosis
during
myocardial
injury.
