Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110802 - 110802
Опубликована: Дек. 1, 2024
Язык: Английский
Biomaterials, Год журнала: 2024, Номер 306, С. 122478 - 122478
Опубликована: Янв. 21, 2024
Язык: Английский
Процитировано
24
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2071 - 2071
Опубликована: Фев. 8, 2024
Nanoencapsulation has become a recent advancement in drug delivery, enhancing stability, bioavailability, and enabling controlled, targeted substance delivery to specific cells or tissues. However, traditional nanoparticle faces challenges such as short circulation time immune recognition. To tackle these issues, cell membrane-coated nanoparticles have been suggested practical alternative. The production process involves three main stages: lysis membrane fragmentation, isolation, coating. Cell membranes are typically fragmented using hypotonic with homogenization sonication. Subsequent fragments isolated through multiple centrifugation steps. Coating can be achieved extrusion, sonication, combination of both methods. Notably, this analysis reveals the absence universally applicable method for coating, stages differ significantly their procedures. This review explores current developments approaches nanoparticles, highlighting potential an effective alternative various therapeutic applications.
Язык: Английский
Процитировано
17
Journal of Colloid and Interface Science, Год журнала: 2024, Номер 662, С. 413 - 425
Опубликована: Фев. 9, 2024
Язык: Английский
Процитировано
13
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101534 - 101534
Опубликована: Янв. 29, 2025
The treatment and management of kidney diseases pose a significant global burden. Due to the presence blood circulation barriers glomerular filtration barriers, drug therapy for faces challenges such as poor renal targeting, short half-life, severe systemic side effects, severely hindering therapeutic progress. Therefore, research development kidney-targeted agents is great clinical significance. In recent years, application nanotechnology in field nephrology has shown potential revolutionizing diagnosis diseases. Carefully designed nanomaterials can exhibit optimal biological characteristics, influencing various aspects circulation, retention, excretion. Rationally designing modifying based on anatomical structure pathophysiological environment achieve highly specific or nanodrug delivery systems both feasible promising. Based targeted diseases, this review discusses advantages limitations current nanomedicine summarizes active/passive targeting strategies, order further promote through preliminary summary previous studies future prospects.
Язык: Английский
Процитировано
2
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Фев. 28, 2025
Abstract Current diagnostics for sepsis‐associated acute kidney injury (SA‐AKI) detect damage only at advanced stages, limiting opportunities timely intervention. A DNA origami‐based nanoplatform is developed the early diagnosis and treatment of SA‐AKI. Modified with a fluorophore (Cy5) quencher (BHQ3), origami remains nonfluorescent under normal conditions. During SA‐AKI, elevated microRNA‐21 triggers strand displacement reaction that restores fluorescence signal, enabling real‐time detection. Additionally, photoacoustic changes BHQ3, driven by different excretion rates nanostructure released strands, enable dual‐mode imaging, enhancing diagnostic accuracy. Therapeutically, scavenges reactive oxygen species and, when conjugated antimicrobial peptide Leucine‐Leucine‐37 (LL‐37), exhibits bactericidal effects. This combination boosts survival 80% in SA‐AKI models. dual‐response integrates precise imaging targeted therapy, offering powerful strategy management advancing applications precision nanomedicine.
Язык: Английский
Процитировано
2
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Март 29, 2025
Acute kidney injury (AKI) involves the activation of intrarenal hemostatic and inflammatory pathways. Platelets rapidly migrate to affected sites AKI release extracellular vesicles (EVs) laden with bioactive mediators that regulate inflammation hemostasis. While small interfering RNA (siRNA) is a potent gene-silencing tool for biomedical applications, its therapeutic application in vivo remains challenging. We developed an innovative nucleic acid delivery platform by hybridizing synthetic transformation-related protein 53 (p53) siRNA autologous plasma incubating complex platelets. These engineered platelets selectively delivered p53 injured renal tubular cells via EV-mediated cargo release, resulting targeted suppression subsequent attenuation progression. This platelet-centric translational strategy demonstrates significant potential advancing precision therapies exploiting endogenous platelet trafficking deliver therapeutics directly sites.
Язык: Английский
Процитировано
1
Pharmaceutics, Год журнала: 2024, Номер 16(5), С. 651 - 651
Опубликована: Май 11, 2024
Myasthenia gravis (MG) is a rare chronic autoimmune disease caused by the production of autoantibodies against postsynaptic membrane receptors present at neuromuscular junction. This condition characterized fatigue and muscle weakness, including diplopia, ptosis, systemic impairment. Emerging evidence suggests that in addition to immune dysregulation, pathogenesis MG may involve mitochondrial damage ferroptosis. Mitochondria are primary site energy production, reactive oxygen species (ROS) generated due dysfunction can induce Nanomedicines have been extensively employed treat various disorders their modifiability good biocompatibility, but application management has rather limited. Nevertheless, nanodrug delivery systems carry immunomodulatory agents, anti-oxidants, or ferroptosis inhibitors could be effective for treatment MG. Therefore, this review focuses on nanoplatforms aimed attenuating restoring function, inhibiting potentially serve as promising agents targeted therapy.
Язык: Английский
Процитировано
7
International Journal of Dentistry, Год журнала: 2025, Номер 2025(1)
Опубликована: Янв. 1, 2025
Objectives: At 31%, the risk of postoperative bleeding after tooth extraction is particularly high in patients who receive rivaroxaban therapy. The aim this rodent study was to compare hemostyptic properties and gingival healing between novel polyurethane-based adhesive VIVO gelatin sponge (GESP) under ongoing therapy over a period 10 days. Materials: In total, 120 extractions first upper molar were proceeded rodents treated with rivaroxaban. Of these, 60 postextraction sites GESP. duration surgical procedure clinical parameters wound evaluation score recorded. vivo fluorescence imaging laser Doppler flowmetry tissue spectrophotometry (LDF-TS) performed. Results: GESP provided faster at 1:06 ± 0:17 min, but time significantly shorter sockets 1:39 0:03 min. Nonsignificant mild events comparable scores recorded both treatments. LDF-TS showed significant increase mean oxygen saturation SO2 (%) blood flow (AU) for Only relative hemoglobin (rHb). Conclusion: context study, favorable hemostasis promising
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Авг. 9, 2024
The field of oncology has transformed in recent years, with treatments shifting from traditional surgical resection and radiation therapy to more diverse customized approaches, one which is immunotherapy. ICD (immunogenic cell death) belongs a class regulatory death modalities that reactivate the immune response by facilitating interaction between apoptotic cells releasing specific signaling molecules, DAMPs (damage-associated molecular patterns). inducers can elevate expression proteins optimize TME (tumor microenvironment). use nanotechnology shown its unique potential. Nanomaterials, due their tunability, targeting, biocompatibility, have become powerful tools for drug delivery, immunomodulators, etc., significant efficacy clinical trials. In particular, these nanomaterials effectively activate ICD, trigger potent anti-tumor response, maintain long-term tumor suppression. Different types nanomaterials, such as biological membrane-modified nanoparticles, self-assembled nanostructures, metallic mesoporous materials, hydrogels, play respective roles induction structures mechanisms action. Therefore, this review will explore latest advances application common discuss how they provide new strategies cancer therapy. By gaining deeper understanding mechanism action researchers develop precise effective therapeutic approaches improve prognosis quality life patients. Moreover, hold promise overcome resistance conventional therapies, minimize side effects, lead personalized treatment regimens, ultimately benefiting treatment.
Язык: Английский
Процитировано
6
Acta Biomaterialia, Год журнала: 2024, Номер 186, С. 1 - 29
Опубликована: Авг. 14, 2024
Язык: Английский
Процитировано
4