Data-driven inverse design of novel spinodoid bone scaffolds with highly matched mechanical properties in three orthogonal directions

Materials & Design, Год журнала: 2025, Номер unknown, С. 113697 - 113697

Опубликована: Фев. 1, 2025

Язык: Английский

---

Design exploration of staggered hybrid minimal surface magnesium alloy bone scaffolds

International Journal of Mechanical Sciences, Год журнала: 2024, Номер 281, С. 109566 - 109566

Опубликована: Июль 15, 2024

Язык: Английский

---

Shape/properties collaborative intelligent manufacturing of artificial bone scaffold: structural design and additive manufacturing process

Biofabrication, Год журнала: 2024, Номер 17(1), С. 012005 - 012005

Опубликована: Ноя. 8, 2024

Abstract Artificial bone graft stands out for avoiding limited source of autograft as well susceptibility to infection allograft, which makes it a current research hotspot in the field defect repair. However, traditional design and manufacturing method cannot fabricate scaffold that mimics complicated bone-like shape with interconnected porous structure multiple properties akin human natural bone. Additive manufacturing, can achieve implant’s tailored external contour controllable fabrication internal microporous structure, is able form almost any designed via layer-by-layer process. As additive promising building artificial scaffold, only combining excellent structural appropriate process produce ideal biological mechanical properties. In this article, we sum up analyze state art methods realize shape/properties collaborative intelligent manufacturing. Scaffold be mainly classified into based on unit cells whole while basic 3D bioprinting are recommended suitable fabrication. The challenges future perspectives manufactured also discussed.

Язык: Английский

---

Development of an equiatomic octonary TiNbTaZrMoHfWCr super-high-entropy alloy for biomedical applications

Materials Chemistry and Physics, Год журнала: 2024, Номер 316, С. 129120 - 129120

Опубликована: Фев. 21, 2024

A super-high-entropy alloy (SHEA) with ΔSmix > 2.0R (where R is the gas constant) was designed to produce metallic materials superior mechanical properties conventional alloys. As an alternative quinary high-entropy alloys (HEAs), herein, octonary SHEAs for biomedical applications (BioSHEA) are proposed first time, and TiNbTaZrMoHfWCr BioSHEA fabricated. Arc-melted exhibited extremely high yield strength of 1953 ± 84 MPa, which approximately 500 MPa higher than that TiNbTaZrMo BioHEA. This considerably estimated by rule mixtures pure metals, confirming achievement significant solid-solution strengthening induced a supermulticomponent solid solution composed elements different atomic radii. Its biocompatibility comparable Ti BioHEA, SUS316L. study demonstrates validity novel entropy-based guideline increasing mixing entropy achieve ultrahigh strength.

Язык: Английский

---

A Finite Element Study of Simulated Fusion in an L4-L5 Model: Influence of the Combination of Materials in the Screw-and-Rod Fixation System on Reproducing Natural Bone Behavior

Biomimetics, Год журнала: 2025, Номер 10(2), С. 72 - 72

Опубликована: Янв. 24, 2025

The mechanical properties of materials for spinal fixation can significantly affect surgical outcomes. Traditional such as titanium exhibit high stiffness, which lead to stress shielding and adjacent segment degeneration. This study investigates the biomechanical performance PEEK (polyetheretherketone) in using finite element analysis, through evaluation Shielding Strength Factor (SSF). Methods: A three-dimensional analysis (FEA) model an L4/L5 functional unit was developed simulate behavior three systems: screws rods (model A), with B), C). evaluated distribution load transfer under physiological conditions, comparison intact spine (baseline model). Results: showed that systems resulted higher effects, a significant difference compared PEEK. maximum recorded neutral position 24.145 MPa PEEK, indicating better compatibility. Conclusions: results suggest may be attractive alternative fixation, promoting more healthy minimizing risk complications.

Язык: Английский

---

Mimicking Nature: Effect of Architectural Design Inspired by Cancellous Bone on the Biological Response of hMSC Cultured on Titanium Scaffolds Fabricated by Laser Beam Powder Bed Fusion

Journal of Biomedical Materials Research Part A, Год журнала: 2025, Номер 113(1)

Опубликована: Янв. 1, 2025

ABSTRACT Bone tissue regeneration can be affected by various architectonical features of 3D porous scaffold, for example, pore size and shape, strut size, curvature, or porosity. However, the design additively manufactured structures studied so far was based on uniform geometrical figures unit cell structures, which often do not resemble natural architecture cancellous bone. Therefore, aim this study to investigate effect (aka printed) titanium scaffolds designed microtomographic scans fragments human femurs individuals different ages in vitro response bone‐derived mesenchymal stem cells (hMSC). Four types scaffold (33Y, 48Y, 56Y, 63Y, where number indicates age individual) were fabricated using laser beam powder bed fusion (PBF‐LB) characterized with respect dimensional features, permeability, stiffness. hMSC seeded onto MTS, DNA, alkaline phosphatase, alizarin red assays used viability, proliferation, osteogenic differentiation. Microcomputed tomography revealed that largest average 63Y (543 ± 200 μm), nearly twice as large smallest pores 56Y. Moreover, exhibited highest porosity (~61%), while other architectures had ~43%–44%. Scaffolds also lowest surface area‐to‐volume ratio (11.07 0.05 mm −1 ), whereas 56Y (14.80 0.06 ). Furthermore, 33Y (398 124 exceeding (the size) over 1.5 times. CFD simulations indicated hydraulic permeability (5.24 × 10 −9 m 2 ; order magnitude higher than architectures). Stiffness investigated scaffolds, determined finite element modeling, ranged from ~29 GPa (63Y) ~60 (56Y). This demonstrates manufacturing accuracy printed architectural designs inspired bone could achieved when moderate sizes, pores, permeability. The (i.e., 63Y) yielded retention. Regarding differentiation, a correlation found between mineralization deposited extracellular matrix but

Язык: Английский

---

3D-Printed Thermally Activated Shape Memory PLA/TBC Composite Scaffold with Body-Compatible Temperature for Minimally Invasive Bone Repair

ACS Applied Polymer Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Язык: Английский

---

Structure and Property Evolution of Microinjection Molded PLA/PCL/Bioactive Glass Composite

Polymers, Год журнала: 2025, Номер 17(7), С. 991 - 991

Опубликована: Апрель 6, 2025

In this study, the microinjection molding technology was adopted to prepare polylactic acid (PLA)/polycaprolactone (PCL)/bioactive glass (BG) composites with varying BG contents for biomedical applications. The various measurement techniques, including scanning electronic microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, water contact angle (WCA) test, mechanical and in vitro biological evaluations, were applied characterize above interesting biocomposites. experimental results show that extremely strong shear force field generated during process could induce situ formation of micron PCL dispersed phase fibril structures strongly promote homogeneous dispersion filler particles PLA/PCL polymer matrix, which therefore leads a significant improvement specific property PLA/PCL/BG composite. For example, fillers content increasing 10 wt%, Young's modulus obtained composite reach 2122.9 MPa, is 1.47 times higher than unfilled blend material. addition, it also found under simulated body fluid (SBF) environment, incorporated matrix be effectively transformed into hydroxyapatite (HA) components on treated sample surface, thus being greatly advantageous enhancing material's bioactivity. Obviously, molded biocomposites exhibit excellent comprehensive performance, revealing processing method hold great potential industrialization applications resulting biodegradable materials.

Язык: Английский

---

Design, Manufacture, and Characterization of a Critical-Sized Gradient Porosity Dual-Material Tibial Defect Scaffold

Bioengineering, Год журнала: 2024, Номер 11(4), С. 308 - 308

Опубликована: Март 25, 2024

This study proposed a composite tibia defect scaffold with radial gradient porosity, utilizing finite element analysis to assess stress in the tibial region significant critical-sized defects. Simulations for scaffolds different porosities were conducted, designing an optimal porosity repairing and replacing critical bone Radial resulted more uniform distribution, reducing titanium alloy stiffness alleviating shielding effects. The was manufactured using selective laser melting (SLM) technology relief annealing simplify porous structure fabrication. used New Zealand white rabbits’ sites as simulation parameters, reconstructing 3D model implanting scaffold. Finite ANSYS-Workbench simulated forces under high-activity conditions, analyzing distribution strain. In simulation, bore maximum of 122.8626 MPa, while centrally encapsulated HAp material delivered 27.92 MPa. design demonstrated superior structural strength, thereby concentration. SLM, method determine collection optimum parameters. Nanoindentation compression tests influence on elastic modulus, hardness, strain energy

Язык: Английский

---

Surface engineering of Orthopedic implants for better clinical adoption

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(44), С. 11302 - 11335

Опубликована: Янв. 1, 2024

Enhancing cell-material interactions through surface engineering to create biomimetic environments and extend implant life.

Язык: Английский

---