Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Biomechanical
complications,
such
as
stress
shielding,
bone
resorption,
and
reconstruction
failure,
are
prevalently
associated
with
solid
titanium
mandible
plates.
This
study
evaluates
the
potential
of
metamaterial
designs
porous
gyroid
microarchitectures,
to
enhance
biomechanical
stimulation
mitigate
these
complications.
A
novel
plate
is
compared
plates,
both
patient-specifically
designed
fabricated
from
Ti6Al4
V
alloy.
Stress
shielding
assessed
through
photoelasticity
experiments
validated
finite
element
analysis
(FEA).
Transparent
models
loaded
incrementally
(0-1000
N)
analyze
distributions
in
implants,
screws,
segments.
The
reduces
concentrations
distant
mandibular
regions
defect,
while
increasing
around
screws
near
favoring
local
mechanical
stimulation.
FEA
confirms
improved
load
distribution
(p
=
0.003).
However,
exhibited
a
lower
load-bearing
capacity,
failing
at
775
N,
withstood
1800
N
without
failure.
Yet,
design
effectively
reduced
thereby
enhancing
function
critical
regions.
Hence,
despite
their
they
can,
potentially,
preserve
integrity
prevent
implant
failure
that
should
be
future
(pre-)clinical
studies.
Biofabrication,
Год журнала:
2024,
Номер
17(1), С. 012005 - 012005
Опубликована: Ноя. 8, 2024
Abstract
Artificial
bone
graft
stands
out
for
avoiding
limited
source
of
autograft
as
well
susceptibility
to
infection
allograft,
which
makes
it
a
current
research
hotspot
in
the
field
defect
repair.
However,
traditional
design
and
manufacturing
method
cannot
fabricate
scaffold
that
mimics
complicated
bone-like
shape
with
interconnected
porous
structure
multiple
properties
akin
human
natural
bone.
Additive
manufacturing,
can
achieve
implant’s
tailored
external
contour
controllable
fabrication
internal
microporous
structure,
is
able
form
almost
any
designed
via
layer-by-layer
process.
As
additive
promising
building
artificial
scaffold,
only
combining
excellent
structural
appropriate
process
produce
ideal
biological
mechanical
properties.
In
this
article,
we
sum
up
analyze
state
art
methods
realize
shape/properties
collaborative
intelligent
manufacturing.
Scaffold
be
mainly
classified
into
based
on
unit
cells
whole
while
basic
3D
bioprinting
are
recommended
suitable
fabrication.
The
challenges
future
perspectives
manufactured
also
discussed.
Materials Chemistry and Physics,
Год журнала:
2024,
Номер
316, С. 129120 - 129120
Опубликована: Фев. 21, 2024
A
super-high-entropy
alloy
(SHEA)
with
ΔSmix
>
2.0R
(where
R
is
the
gas
constant)
was
designed
to
produce
metallic
materials
superior
mechanical
properties
conventional
alloys.
As
an
alternative
quinary
high-entropy
alloys
(HEAs),
herein,
octonary
SHEAs
for
biomedical
applications
(BioSHEA)
are
proposed
first
time,
and
TiNbTaZrMoHfWCr
BioSHEA
fabricated.
Arc-melted
exhibited
extremely
high
yield
strength
of
1953
±
84
MPa,
which
approximately
500
MPa
higher
than
that
TiNbTaZrMo
BioHEA.
This
considerably
estimated
by
rule
mixtures
pure
metals,
confirming
achievement
significant
solid-solution
strengthening
induced
a
supermulticomponent
solid
solution
composed
elements
different
atomic
radii.
Its
biocompatibility
comparable
Ti
BioHEA,
SUS316L.
study
demonstrates
validity
novel
entropy-based
guideline
increasing
mixing
entropy
achieve
ultrahigh
strength.
Biomimetics,
Год журнала:
2025,
Номер
10(2), С. 72 - 72
Опубликована: Янв. 24, 2025
The
mechanical
properties
of
materials
for
spinal
fixation
can
significantly
affect
surgical
outcomes.
Traditional
such
as
titanium
exhibit
high
stiffness,
which
lead
to
stress
shielding
and
adjacent
segment
degeneration.
This
study
investigates
the
biomechanical
performance
PEEK
(polyetheretherketone)
in
using
finite
element
analysis,
through
evaluation
Shielding
Strength
Factor
(SSF).
Methods:
A
three-dimensional
analysis
(FEA)
model
an
L4/L5
functional
unit
was
developed
simulate
behavior
three
systems:
screws
rods
(model
A),
with
B),
C).
evaluated
distribution
load
transfer
under
physiological
conditions,
comparison
intact
spine
(baseline
model).
Results:
showed
that
systems
resulted
higher
effects,
a
significant
difference
compared
PEEK.
maximum
recorded
neutral
position
24.145
MPa
PEEK,
indicating
better
compatibility.
Conclusions:
results
suggest
may
be
attractive
alternative
fixation,
promoting
more
healthy
minimizing
risk
complications.
Journal of Biomedical Materials Research Part A,
Год журнала:
2025,
Номер
113(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Bone
tissue
regeneration
can
be
affected
by
various
architectonical
features
of
3D
porous
scaffold,
for
example,
pore
size
and
shape,
strut
size,
curvature,
or
porosity.
However,
the
design
additively
manufactured
structures
studied
so
far
was
based
on
uniform
geometrical
figures
unit
cell
structures,
which
often
do
not
resemble
natural
architecture
cancellous
bone.
Therefore,
aim
this
study
to
investigate
effect
(aka
printed)
titanium
scaffolds
designed
microtomographic
scans
fragments
human
femurs
individuals
different
ages
in
vitro
response
bone‐derived
mesenchymal
stem
cells
(hMSC).
Four
types
scaffold
(33Y,
48Y,
56Y,
63Y,
where
number
indicates
age
individual)
were
fabricated
using
laser
beam
powder
bed
fusion
(PBF‐LB)
characterized
with
respect
dimensional
features,
permeability,
stiffness.
hMSC
seeded
onto
MTS,
DNA,
alkaline
phosphatase,
alizarin
red
assays
used
viability,
proliferation,
osteogenic
differentiation.
Microcomputed
tomography
revealed
that
largest
average
63Y
(543
±
200
μm),
nearly
twice
as
large
smallest
pores
56Y.
Moreover,
exhibited
highest
porosity
(~61%),
while
other
architectures
had
~43%–44%.
Scaffolds
also
lowest
surface
area‐to‐volume
ratio
(11.07
0.05
mm
−1
),
whereas
56Y
(14.80
0.06
).
Furthermore,
33Y
(398
124
exceeding
(the
size)
over
1.5
times.
CFD
simulations
indicated
hydraulic
permeability
(5.24
×
10
−9
m
2
;
order
magnitude
higher
than
architectures).
Stiffness
investigated
scaffolds,
determined
finite
element
modeling,
ranged
from
~29
GPa
(63Y)
~60
(56Y).
This
demonstrates
manufacturing
accuracy
printed
architectural
designs
inspired
bone
could
achieved
when
moderate
sizes,
pores,
permeability.
The
(i.e.,
63Y)
yielded
retention.
Regarding
differentiation,
a
correlation
found
between
mineralization
deposited
extracellular
matrix
but
Polymers,
Год журнала:
2025,
Номер
17(7), С. 991 - 991
Опубликована: Апрель 6, 2025
In
this
study,
the
microinjection
molding
technology
was
adopted
to
prepare
polylactic
acid
(PLA)/polycaprolactone
(PCL)/bioactive
glass
(BG)
composites
with
varying
BG
contents
for
biomedical
applications.
The
various
measurement
techniques,
including
scanning
electronic
microscopy
(SEM),
X-ray
diffraction
(XRD),
Fourier
transform
infrared
(FT-IR)
spectroscopy,
water
contact
angle
(WCA)
test,
mechanical
and
in
vitro
biological
evaluations,
were
applied
characterize
above
interesting
biocomposites.
experimental
results
show
that
extremely
strong
shear
force
field
generated
during
process
could
induce
situ
formation
of
micron
PCL
dispersed
phase
fibril
structures
strongly
promote
homogeneous
dispersion
filler
particles
PLA/PCL
polymer
matrix,
which
therefore
leads
a
significant
improvement
specific
property
PLA/PCL/BG
composite.
For
example,
fillers
content
increasing
10
wt%,
Young's
modulus
obtained
composite
reach
2122.9
MPa,
is
1.47
times
higher
than
unfilled
blend
material.
addition,
it
also
found
under
simulated
body
fluid
(SBF)
environment,
incorporated
matrix
be
effectively
transformed
into
hydroxyapatite
(HA)
components
on
treated
sample
surface,
thus
being
greatly
advantageous
enhancing
material's
bioactivity.
Obviously,
molded
biocomposites
exhibit
excellent
comprehensive
performance,
revealing
processing
method
hold
great
potential
industrialization
applications
resulting
biodegradable
materials.
Bioengineering,
Год журнала:
2024,
Номер
11(4), С. 308 - 308
Опубликована: Март 25, 2024
This
study
proposed
a
composite
tibia
defect
scaffold
with
radial
gradient
porosity,
utilizing
finite
element
analysis
to
assess
stress
in
the
tibial
region
significant
critical-sized
defects.
Simulations
for
scaffolds
different
porosities
were
conducted,
designing
an
optimal
porosity
repairing
and
replacing
critical
bone
Radial
resulted
more
uniform
distribution,
reducing
titanium
alloy
stiffness
alleviating
shielding
effects.
The
was
manufactured
using
selective
laser
melting
(SLM)
technology
relief
annealing
simplify
porous
structure
fabrication.
used
New
Zealand
white
rabbits’
sites
as
simulation
parameters,
reconstructing
3D
model
implanting
scaffold.
Finite
ANSYS-Workbench
simulated
forces
under
high-activity
conditions,
analyzing
distribution
strain.
In
simulation,
bore
maximum
of
122.8626
MPa,
while
centrally
encapsulated
HAp
material
delivered
27.92
MPa.
design
demonstrated
superior
structural
strength,
thereby
concentration.
SLM,
method
determine
collection
optimum
parameters.
Nanoindentation
compression
tests
influence
on
elastic
modulus,
hardness,
strain
energy