Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 19, 2024
Abstract
Fusobacterium
nucleatum
(
Fn
),
as
an
intestinal
pathogenic
bacterium,
is
closely
related
to
the
occurrence,
progression,
and
limited
therapeutic
efficacy
of
colorectal
cancer
(CRC).
The
presence
within
CRC
communities
induces
inflammatory
immunosuppressive
microenvironment
while
promoting
new
vessel
formation.
Therefore,
developing
novel
methods
efficiently
eliminate
enhance
outcomes
against
‐associated
great
significance.
Herein,
a
nanosystem
named
AFGTs‐PEG
,
which
integrates
antimicrobial
agent
lauric
acid
(LA),
antiangiogenic
gene
(sFlt‐1),
targeted
polymer
(OEI‐LA/PBA,
OLP),
DSPE‐mPEG,
boost
therapy
‐infected
CRC,
developed.
sFlt‐1
delivered
cells
through
lysosome
escape,
remarkably
inhibiting
formation
at
site
ultimately
leading
cell
death.
In
principle,
LA
used
its
biofilms,
remodel
by
restraining
generation
factors
preventing
polarization
M1
into
M2
macrophages,
thereby
mitigating
adverse
effects
on
therapy.
This
study
holds
promise
for
treatment
bacteria‐colonized
tumors.
Materials,
Год журнала:
2024,
Номер
17(24), С. 6064 - 6064
Опубликована: Дек. 11, 2024
Magnetic
nanoparticles
have
attracted
significant
attention
in
nanoscience
and
nanotechnology
due
to
their
unique
physicochemical
properties.
These
properties
enable
great
potential
various
biomedical
applications,
such
as
hyperthermia,
drug
delivery,
tissue
engineering,
theranostics,
lab-on-a-chip
technologies.
Physical
chemical
methods
are
conventionally
used
for
the
synthesis
of
nanoparticles;
however,
several
limitations
these
methods,
research
focus
has
recently
shifted
towards
developing
clean
eco-friendly
protocols
while
maintaining
desirable
physical
In
this
study,
iron
oxide
(FeNPs)
were
synthesized
first
time
using
green
method
with
extracts
from
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(43), С. 11110 - 11122
Опубликована: Янв. 1, 2024
The
challenge
of
enhancing
wound
healing
and
skin
regeneration,
particularly
in
conditions
like
burns
diabetic
wounds,
necessitates
innovative
solutions.
Cholesterol,
often
associated
with
cardiovascular
diseases,
plays
vital
roles
cellular
functions,
maintaining
integrity
preserving
the
barrier.
Here,
we
explore
cholesterol's
significance,
its
influence
on
keratinocytes,
potential
application
regeneration.
study
utilizes
electrospun
polyimide
(PI)
fibers
as
a
cholesterol
carrier
model
investigates
impact
HaCaT
marking
first
time
tracked
delivery
from
scaffold
into
cells.
We
demonstrate
that
an
optimal
concentration
0.7
mM
medium
enhances
cell
proliferation,
while
higher
concentrations
have
negative
effects.
Cholesterol-enriched
scaffolds
significantly
increase
proliferation
replicative
activity,
especially
3D
culture
environment.
Moreover,
influences
keratinocyte
differentiation,
promoting
early
differentiation
inhibiting
late
differentiation.
These
findings
suggest
cholesterol-loaded
can
applications
by
growth,
regulating
potentially
accelerating
closure.
Further
research
this
area
will
lead
to
management
tissue
regeneration
strategies.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
Cancer-related
anemia
(CRA),
a
complication
of
cancer,
is
considered
the
primary
cause
high
mortality
for
cancer
patients.
Safe
and
effective
theranostics
are
desirable
realizing
diagnostic
accuracy
tumors
ameliorating
CRA
in
clinic.
However,
available
do
not
support
dual-modal
imaging
amelioration
at
same
time.
In
this
study,
we
synthesized
functionalized
iron
oxide
nanoparticles
(Fe3O4
NPs)
modified
with
protoporphyrin
IX
(PPIX)
folic
acid
(FA)
by
one-step
modification
strategy
(Fe3O4@NH-PPIX&FA
or
step-by-step
(Fe3O4@NH-PPIX-FA
NPs),
aiming
both
magnetic
resonance
imaging/fluorescence
(MRI/FI)
erythropoiesis.
Fe3O4@NH-PPIX-FA
NPs
displayed
better
ability
MRI/FI
than
Fe3O4@NH-PPIX&FA
had
an
efficient
tumor
targeting
45
min
after
tail
vein
injection
owing
to
reduction
steric
effect
extension
FA
groups.
exhibited
satisfactory
erythropoiesis
up
20%
elevation
red
blood
cell
(RBC)
counts
hemoglobin
concentrations
mice
CRA,
which
provided
safe
alternative
RBC
transfusions,
especially
patients
needing
recurrent
transfusions.
With
excellent
performance
erythropoiesis,
could
be
powerful
tool
anemia.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 19, 2024
Abstract
Fusobacterium
nucleatum
(
Fn
),
as
an
intestinal
pathogenic
bacterium,
is
closely
related
to
the
occurrence,
progression,
and
limited
therapeutic
efficacy
of
colorectal
cancer
(CRC).
The
presence
within
CRC
communities
induces
inflammatory
immunosuppressive
microenvironment
while
promoting
new
vessel
formation.
Therefore,
developing
novel
methods
efficiently
eliminate
enhance
outcomes
against
‐associated
great
significance.
Herein,
a
nanosystem
named
AFGTs‐PEG
,
which
integrates
antimicrobial
agent
lauric
acid
(LA),
antiangiogenic
gene
(sFlt‐1),
targeted
polymer
(OEI‐LA/PBA,
OLP),
DSPE‐mPEG,
boost
therapy
‐infected
CRC,
developed.
sFlt‐1
delivered
cells
through
lysosome
escape,
remarkably
inhibiting
formation
at
site
ultimately
leading
cell
death.
In
principle,
LA
used
its
biofilms,
remodel
by
restraining
generation
factors
preventing
polarization
M1
into
M2
macrophages,
thereby
mitigating
adverse
effects
on
therapy.
This
study
holds
promise
for
treatment
bacteria‐colonized
tumors.
