Advanced Dressings for Chronic Wound Management

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(5), С. 2660 - 2676

Опубликована: Май 9, 2024

Wound healing, particularly for chronic wounds, presents a considerable difficulty due to differences in biochemical and cellular processes that occur different types of wounds. Recent technological breakthroughs have notably advanced the understanding diagnostic therapeutic approaches wound healing. The evolution care has seen transition from traditional textile dressings variety alternatives, including self-healing hydrogels, hydrofibers, foams, hydrocolloids, environment responsive dressings, growth factor-based therapy, bioengineered skin substitutes, stem cell gene therapy. Technological advancements, such as 3D printing electronic (e-skin) contribute customization Despite these effectively managing wounds remains challenging. This necessitates development treatments consider performance, risk–benefit balance, cost-effectiveness. review discusses innovative strategies healing Incorporating biomarkers into coupled with corresponding biosensors drug delivery formulations, enables theranostic approach treatment Furthermore, integrating power sources user interfaces like near-field communication, radio frequency identification, Bluetooth enhances real-time monitoring on-demand delivery. It also provides thorough evaluation advantages, patient compliance, costs, durability emphasizing smart formulations their preparation methods.

Язык: Английский

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Interfacial Engineering Enhancing Electron Transfer of CaF₂ Nanoparticles for Periodontitis Treatment of Sonotherapy and Bone Resorption

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Conventional periodontitis treatments can be superseded by sonodynamic therapy. In this study, a Zn(OH)F/CaF2 heterojunction was synthesized via hydrothermal method, which exhibited good biocompatibility and antibacterial properties. The band gap decreased significantly after the formation of heterojunction, thereby enhancing internal electron transfer. addition, bacteria contact with material, electrons transport chain turn to affect its steady state. Ultimately, H2O2 in an inflammatory environment used react facilitate transfer under influence ultrasound, ultimately catalytic activity. exhibits significant efficacy against Porphyromonas gingivalis Staphylococcus aureus. Trace elements Ca Zn promote tissue repair osteogenic differentiation, resulting less bone destruction intact gingival treatment. This therapy provides rapid antibacterial, effective, deep therapeutic method for treating periodontitis.

Язык: Английский

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Synergistic Photothermal and Photodynamic Therapy against Bacterial Infections Using Carbon Quantum Dots Modified Molybdenum Disulfide

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Язык: Английский

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Stable and biocompatible multivalent polymer‐grafted gold nanorods for enhanced photothermal antibacterial therapy

Journal of Applied Polymer Science, Год журнала: 2024, Номер unknown

Опубликована: Сен. 4, 2024

Abstract Near‐infrared laser‐activated gold nanorods (AuNRs) with excellent photothermal property and tunable surface functionalization are considered as an ideal platform for biomedical applications. However, bare AuNRs have cytotoxicity against normal cells prone to agglomeration during laser irradiation. Herein, multivalent polymer‐functionalized (AuNRs@pDMAEMA‐C 4 ) was constructed a highly stable biocompatible agent enhanced antibacterial therapy. The functionalized polymer synthetized via the reversible addition‐fragmentation chain transfer polymerization subsequently quaternized. Moreover, positively charged AuNRs@pDMAEMA‐C can easily capture bacterial electrostatic interactions. integration of therapy chemotherapy achieve effects. Under 808 nm irradiation, possessed conversion capability kill gram‐positive gram‐negative bacteria. Study mechanism indicated that action prepared cause serious damage outer membranes, result in cytoplasm leakage death. nanocomposites combining near‐infrared irradiation facilitate rapid healing bacteria‐infected wound by rat model infection histological analysis tissues. These results suggest be used potential strategy fabricate light‐activated therapeutic

Язык: Английский

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POM‐Based Hydrogels for Efficient Synergistic Chemodynamic/Low‐Temperature Photothermal Antibacterial Therapy

Macromolecular Rapid Communications, Год журнала: 2024, Номер 45(23)

Опубликована: Окт. 14, 2024

Abstract Bacterial infection of wound surfaces has posed a significant threat to human health and represents formidable challenge in the clinical treatment. In this study, novel antimicrobial hydrogel utilizing POM is synthesized as primary component, with gelatin sodium alginate structural framework. The resultant demonstrates exceptional mechanical properties viscoelasticity attributed hydrogen‐bonded cross‐linking between gelatin, well ionic Ca 2+ . addition, integration CuS nanoparticles conferred photothermal system. To address concerns regarding potential thermal damage surrounding normal cells, study employs LT‐PTT combined CDT approach achieve enhanced efficacy while minimizing inadvertent harm healthy cells. findings suggested that POM‐based hydrogels, serving an inorganic–organic hybrid material, will represent promising solution offer valuable insights for development non‐antibiotic materials.

Язык: Английский

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Enhanced bactericidal performance of textiles through compound antimicrobial agents

Biointerphases, Год журнала: 2024, Номер 19(3)

Опубликована: Май 1, 2024

This study aims to explore the essential functional requirements associated with controlling proliferation of microbes in domain textiles used public health areas. Herein, three antimicrobial agents, specifically iodopropylbutylcarbamate (IPBC), 1-hydroxypyridine-2-thioketone zinc (ZPT), and 2-octyl-3-isothiazolinone (OIT), were chosen for fabric finishing based on their notable effectiveness, minimal toxicity, cost-efficiency, chemical stability. Utilizing Staphylococcus aureus (S. aureus) Escherichia coli (E. coli) as representative bacterial strains, Minimum Inhibitory Concentration (MIC50) individual combined agents was measured, effectiveness rigorously evaluated. Concurrently, whiteness, mechanical durability following treatment thoroughly examined. The results demonstrate that some combinations elicit additive effects both S. E. coli. Notably, at an equivalent ratio IPBC, ZPT, OIT a total concentration 0.2 wt. %, inhibition rates against strains surpass 99%. Upon application nylon fabric, treated material demonstrates significant properties, reduction observed whiteness tensile strength nylon. provides practicable strategies relevant production endowed properties.

Язык: Английский

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MXene/Metal–Organic Framework Heterojunctions Facilitate Bacterial-Infected Wound Repair via Exogenous and Endogenous Synergistic Stimulations

ACS Materials Letters, Год журнала: 2024, Номер 6(10), С. 4596 - 4605

Опубликована: Сен. 4, 2024

Язык: Английский

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