Macrophage-based cancer immunotherapy: Challenges and opportunities
Experimental Cell Research,
Год журнала:
2024,
Номер
442(1), С. 114198 - 114198
Опубликована: Авг. 3, 2024
Язык: Английский
Biomineralized and metallized small extracellular vesicles encapsulated in hydrogels for mitochondrial-targeted synergistic tumor therapy
Acta Biomaterialia,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Advances in Stem Cell Therapy for Acute Lung Injury: A Review
Journal of Clinical Personalized Medicine,
Год журнала:
2025,
Номер
04(01), С. 326 - 333
Опубликована: Янв. 1, 2025
Язык: Английский
Precision nanomedicine: navigating the tumor microenvironment for enhanced cancer immunotherapy and targeted drug delivery
Molecular Cancer,
Год журнала:
2025,
Номер
24(1)
Опубликована: Июнь 3, 2025
Cancer
treatment
has
been
revolutionized
by
immunotherapy
and
nanomedicine,
offering
innovative
strategies
to
overcome
the
tumor
microenvironment
(TME)
complexities.
However,
challenges
such
as
therapeutic
resistance,
off-target
effects,
immune
suppression
necessitate
advanced
delivery
systems
combination
approaches.
Recent
advancements
in
nanoparticle-based
therapies,
biomimetic
platforms,
personalized
provide
promising
solutions
enhance
efficacy
while
minimizing
systemic
toxicity.
This
review
explores
recent
nanoparticle-mediated
developments,
highlighting
optimize
drug
delivery,
remodel
TME,
improve
patient-specific
outcomes.
A
comprehensive
of
literature
focused
on
stimuli-responsive
systems,
nanoplatforms,
The
effectiveness
therapies
integrating
physical
immunological
was
also
analyzed.
Nanoparticle-mediated
enables
precise
targeting
controlled
release,
significantly
improving
Biomimetic
nanoplatforms
modulation
bioavailability,
immunotherapy,
guided
predictive
biomarkers,
tailors
individual
patients.
Advanced
nanomedicine
strategies,
including
TME
remodeling,
targeted
genome
editing,
immunotherapies,
offer
avenues
for
overcoming
limitations
conventional
cancer
treatments.
Future
research
should
nanoformulations,
integrate
multi-modal
refine
biomarker-driven
personalization
clinical
Язык: Английский
Nano-enabled regulation of DNA damage in tumor cells to enhance neoantigen-based pancreatic cancer immunotherapy
Biomaterials,
Год журнала:
2024,
Номер
311, С. 122710 - 122710
Опубликована: Июль 21, 2024
Язык: Английский
Application of Macrophage Subtype Analysis in Acute Lung Injury/Acute Respiratory Distress Syndrome
Frontiers in Bioscience-Landmark,
Год журнала:
2024,
Номер
29(12)
Опубликована: Дек. 6, 2024
Acute
lung
injury
(ALI)/acute
respiratory
distress
syndrome
(ARDS)
is
a
common
critical
illness.
Supportive
therapy
still
the
main
strategy
for
ALI/ARDS.
Macrophages
are
predominant
immune
cells
in
lungs
and
play
pivotal
role
maintaining
homeostasis,
regulating
metabolism,
facilitating
tissue
repair.
During
ALI/ARDS,
these
versatile
undergo
polarization
into
distinct
subtypes
with
significant
variations
transcriptional
profiles,
developmental
trajectory,
phenotype,
functionality.
This
review
discusses
developments
analysis
of
alveolar
macrophage
study
potential
value
targeting
new
diagnosis,
prognostic
evaluation,
treatment
Язык: Английский