Application of Macrophage Subtype Analysis in Acute Lung Injury/Acute Respiratory Distress Syndrome DOI Creative Commons

Jiajia Tang,

Jun Shi,

Zhihai Han

и другие.

Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(12)

Опубликована: Дек. 6, 2024

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common critical illness. Supportive therapy still the main strategy for ALI/ARDS. Macrophages are predominant immune cells in lungs and play pivotal role maintaining homeostasis, regulating metabolism, facilitating tissue repair. During ALI/ARDS, these versatile undergo polarization into distinct subtypes with significant variations transcriptional profiles, developmental trajectory, phenotype, functionality. This review discusses developments analysis of alveolar macrophage study potential value targeting new diagnosis, prognostic evaluation, treatment

Язык: Английский

Macrophage-based cancer immunotherapy: Challenges and opportunities DOI
Haotian Bai, Li Feng,

F Schmid

и другие.

Experimental Cell Research, Год журнала: 2024, Номер 442(1), С. 114198 - 114198

Опубликована: Авг. 3, 2024

Язык: Английский

Процитировано

6

Biomineralized and metallized small extracellular vesicles encapsulated in hydrogels for mitochondrial-targeted synergistic tumor therapy DOI
Qi Zhang,

Ruofei Ma,

Siwen Chen

и другие.

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Advances in Stem Cell Therapy for Acute Lung Injury: A Review DOI Open Access

阳 杨

Journal of Clinical Personalized Medicine, Год журнала: 2025, Номер 04(01), С. 326 - 333

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Precision nanomedicine: navigating the tumor microenvironment for enhanced cancer immunotherapy and targeted drug delivery DOI Creative Commons
Hussein Sabit, Timothy M. Pawlik,

Faisal F.Y. Radwan

и другие.

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Июнь 3, 2025

Cancer treatment has been revolutionized by immunotherapy and nanomedicine, offering innovative strategies to overcome the tumor microenvironment (TME) complexities. However, challenges such as therapeutic resistance, off-target effects, immune suppression necessitate advanced delivery systems combination approaches. Recent advancements in nanoparticle-based therapies, biomimetic platforms, personalized provide promising solutions enhance efficacy while minimizing systemic toxicity. This review explores recent nanoparticle-mediated developments, highlighting optimize drug delivery, remodel TME, improve patient-specific outcomes. A comprehensive of literature focused on stimuli-responsive systems, nanoplatforms, The effectiveness therapies integrating physical immunological was also analyzed. Nanoparticle-mediated enables precise targeting controlled release, significantly improving Biomimetic nanoplatforms modulation bioavailability, immunotherapy, guided predictive biomarkers, tailors individual patients. Advanced nanomedicine strategies, including TME remodeling, targeted genome editing, immunotherapies, offer avenues for overcoming limitations conventional cancer treatments. Future research should nanoformulations, integrate multi-modal refine biomarker-driven personalization clinical

Язык: Английский

Процитировано

0

Nano-enabled regulation of DNA damage in tumor cells to enhance neoantigen-based pancreatic cancer immunotherapy DOI
Jilong Wang,

Chenghu Wu,

Yiran Wang

и другие.

Biomaterials, Год журнала: 2024, Номер 311, С. 122710 - 122710

Опубликована: Июль 21, 2024

Язык: Английский

Процитировано

2

Application of Macrophage Subtype Analysis in Acute Lung Injury/Acute Respiratory Distress Syndrome DOI Creative Commons

Jiajia Tang,

Jun Shi,

Zhihai Han

и другие.

Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(12)

Опубликована: Дек. 6, 2024

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common critical illness. Supportive therapy still the main strategy for ALI/ARDS. Macrophages are predominant immune cells in lungs and play pivotal role maintaining homeostasis, regulating metabolism, facilitating tissue repair. During ALI/ARDS, these versatile undergo polarization into distinct subtypes with significant variations transcriptional profiles, developmental trajectory, phenotype, functionality. This review discusses developments analysis of alveolar macrophage study potential value targeting new diagnosis, prognostic evaluation, treatment

Язык: Английский

Процитировано

0