Leveraging artificial intelligence in vaccine development: A narrative review

Journal of Microbiological Methods, Год журнала: 2024, Номер 224, С. 106998 - 106998

Опубликована: Июль 15, 2024

Vaccine development stands as a cornerstone of public health efforts, pivotal in curbing infectious diseases and reducing global morbidity mortality. However, traditional vaccine methods are often time-consuming, costly, inefficient. The advent artificial intelligence (AI) has ushered new era design, offering unprecedented opportunities to expedite the process. This narrative review explores role AI development, focusing on antigen selection, epitope prediction, adjuvant identification, optimization strategies. algorithms, including machine learning deep learning, leverage genomic data, protein structures, immune system interactions predict antigenic epitopes, assess immunogenicity, prioritize antigens for experimentation. Furthermore, AI-driven approaches facilitate rational design immunogens identification novel candidates with optimal safety efficacy profiles. Challenges such data heterogeneity, model interpretability, regulatory considerations must be addressed realize full potential development. Integrating emerging technologies, single-cell omics synthetic biology, promises enhance precision scalability. underscores transformative impact highlights need interdisciplinary collaborations harmonization accelerate delivery safe effective vaccines against diseases.

Язык: Английский

---

Role of the Extracellular Matrix in Cancer: Insights into Tumor Progression and Therapy

Advanced Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Abstract The extracellular matrix (ECM) serves not only as a structural scaffold but also an active regulator of cancer progression, profoundly influencing tumor behaviour and the microenvironment (TME). This review focuses into pivotal role ECM alterations in facilitating metastasis explores therapeutic strategies aimed at counteracting these changes. We analyse targeted interventions against collagen, including approaches to inhibit its biosynthesis disrupt associated signalling pathways critical for architecture cell migration. Additionally, therapies addressing hyaluronan are reviewed, highlighting methods suppress synthesis enzymatic degrade it, thereby mitigating tumor‐promoting effects. discussion extends innovative modulating stiffness, focusing on roles cancer‐associated fibroblasts lysyl oxidases, which key contributors remodelling mechanical signalling. By strategically modifying components, aim enhance efficacy existing treatments, tackle resistance mechanisms, achieve more durable outcomes. Insights from recent studies clinical trials highlight promise overcoming treatment improving patient Advancing our understanding biology leads development effective therapies.

Язык: Английский

---

Macrophage membrane-camouflaged pure-drug nanomedicine for synergistic chemo- and interstitial photodynamic therapy against glioblastoma

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

---

Natural Biogenic Templates for Nanomaterial Synthesis: Advances, Applications, and Environmental Perspectives

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

This review explores the use of biogenic templates in nanomaterial synthesis, emphasizing their role promoting environmentally sustainable nanotechnology. It categorizes various templates, including agricultural byproducts and microorganisms, stating suitability for forming nanostructures due to distinct properties. A comparative analysis monostep multistep synthesis methods is provided, focusing on efficiencies outcomes when using templates. Further, this also highlights how these can generate complex hybrid materials with enhanced functionalities. Applications across biomedicine, biotechnology, environmental science, energy are discussed along utilization scope agriculture electronics. Benefits from biotemplates include sustainability, low cost, reduced toxicity, but challenges like scalability, reproducibility, regulatory compliance persist. Future research focuses improving techniques, discovering new evaluating cytotoxic impacts, especially biomedical uses. In conclusion, reaffirms potential while highlighting ongoing that need be addressed broader adoption.

Язык: Английский

---

Nanomaterials in Biomedicine

Опубликована: Янв. 1, 2024

Язык: Английский

---

Nanoparticles in Drug Delivery Systems: Challenges, Innovations, And Surface Modification for Targeted Therapeutics

Indus journal of bioscience research., Год журнала: 2025, Номер 3(1), С. 325 - 336

Опубликована: Янв. 16, 2025

Nanoparticles have become a transforming platform in drug delivery systems. Their remarkable advancement over traditional methods builds upon an improvement bioavailability, stability, and controlled of therapeutic agents. Here, we discuss the broad spectrum potential nanoparticle-based Challenges, innovations, surface modification strategies that affect their clinical translation are discussed. Notwithstanding they present, challenges including biocompatibility, toxicity, targeting efficiency persist restricting extensive utilization. The review emphasizes recent advancements, stimuli-responsive nanoparticles, which provide release reaction to environmental triggers, as well targeted delivery, facilitates selective accumulation agents at designated sites disease. Besides, techniques, such PEGylation, ligand conjugation, charge modulation, been highly promising improving stability reducing immunogenicity, enhancing cellular uptake. future systems based on nanoparticles will address these through new innovations nanoparticle design effect more effective treatments. While research advances, likely bring revolution personalized medicine, tailoring medical therapy for different diseases with minimal side effects better patient outcomes.

Язык: Английский

---

Neoantigen mRNA vaccines and A ₂ A receptor antagonism: A strategy to enhance T cell immunity

Human Vaccines & Immunotherapeutics, Год журнала: 2025, Номер 21(1)

Опубликована: Янв. 30, 2025

Although neo-antigen mRNA vaccines are promising for personalized cancer therapy, their effectiveness is often limited by the immunosuppressive tumor microenvironment (TME). The adenosine A2A receptor (A2AR) inhibits dendritic cell (DC) function and weakens antitumor T responses through hypoxia-driven mechanisms within TME. This review explores a novel strategy combining with A2AR antagonists (A2ARi). By targeting A2AR, this approach reduces TME-induced immunosuppression, enhances DC activation, improves presentation. also discusses lipid nanoparticles (LNPs) to co-deliver A2ARi vaccines, optimizing effectiveness. integration of mRNA-LNPs modulation offers overcome stimulate achieve precise anti-tumor minimal off-target effects. synergy represents significant progress in immunotherapy, advancing potential neoantigen therapies.

Язык: Английский

---

Tungsten-based polyoxometalate nanoclusters as ferroptosis inhibitors modulating S100A8/A9-mediated iron metabolism pathway for managing intracerebral haemorrhage

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 19, 2025

Intracerebral haemorrhage (ICH) is a devastating neurological disorder with high morbidity and mortality rates, largely owing to the lack of effective therapeutic strategies. Growing evidence has underscored pivotal role ferroptosis in intracerebral haemorrhage, its contribution neuronal death exacerbation brain injury, thus establishing it as crucial target for intervention. In recent years, polyoxometalate nanoclusters (NCs) have been applied various neurodegenerative diseases, demonstrating neuroprotective effects. However, their impact on iron content function following ICH yet be reported. Here, we explored potential tungsten-based (W-POM) NCs inhibitors targeting metabolic pathway mediated by S100A8/A9 treatment ICH. We successfully synthesized ultra-small reduced W-POM that can rapidly cross blood-brain barrier are cleared through kidney. vitro experiments demonstrated exhibit significant stable ROS scavenging activity while effectively alleviating overload associated damage. vivo, restored metabolism homeostasis, suppressed neuroinflammation oxidative stress, ultimately severe damage motor deficits mice. Proteomic combined bioinformatic analyses identified two core genes, S100A8 S100A9, most intervention Further confirmed act modulating toll-like receptor 4/hepcidin/ferroportin signaling pathway, thereby regulating reducing secondary injury. This study pioneers application polyoxometalates offering novel promising approach management ferroptosis-related injuries.

Язык: Английский

---

Liposome‐Enabled Nanomaterials for Muscle Regeneration

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Abstract Muscle regeneration is a vital biological process that crucial for maintaining muscle function and integrity, particularly the treatment of diseases such as sarcopenia muscular dystrophy. Generally, tissues can self‐repair regenerate under various conditions, including acute or chronic injuries, aging, genetic mutation. However, becomes challenging beyond certain threshold, in severe injuries progressive diseases. In recent years, liposome‐based nanotechnologies have shown potential promising therapeutic strategies regeneration. Liposomes offer an adaptable platform targeted drug delivery due to their cell membrane‐like structure excellent biocompatibility. They enhance solubility, stability, while minimizing systemic side effects by different mechanisms. This review summarizes advancements, discusses current applications mechanisms, highlights challenges future directions possible clinical translation nanomaterials It hoped this offers new insights into development liposome‐enabled nanomedicine address limitations.

Язык: Английский

---

Stimuli‐Responsive Nano Drug Delivery Systems for the Treatment of Neurological Diseases

Small, Год журнала: 2025, Номер 21(9)

Опубликована: Янв. 22, 2025

Abstract Nanomaterials with unparalleled physical and chemical attributes have become a cornerstone in the field of nanomedicine delivery. These materials can be engineered into various functionalized nanocarriers, which focus research. Stimulus‐responsive nanodrug delivery systems (SRDDS) stand out as sophisticated class nanocarriers that release drugs response to environmental cues. Due complex pathogenesis multifaceted pathological environment nervous system, developing accurate effective drug therapy low side‐effects is formidable task. In recent years, SRDDS been widely used treatment neurological diseases. By customizing align specific microenvironment system tissues or external stimulation, efficacy enhanced. This review provides an in‐depth look at characteristics diseases highlights case studies tailored treat these disorders based on unique stimulation criteria triggers. Additionally, this comprehensive overview progress future prospects technology diseases, providing valuable guidance for its transition from fundamental research clinical application.

Язык: Английский

---