International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 136266 - 136266
Опубликована: Окт. 2, 2024
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Апрель 16, 2025
Chemical overexposure is a significant concern in both environmental and occupational settings, often leading to oxidative stress subsequent cellular damage. The review covers the induced by chemical substances such as pesticides (including pyrethroid, deltamethrin, β-cyfluthrin, malathion, triflumuron, methomyl, diquat, cypermethrin, thiamethoxam, profenofos), medications (acetaminophen), nanoparticles zinc oxide, iron, silver, titanium dioxide), heavy metals cadmium, vanadium), some organic chemicals diethylnitrosamine benzo(a)pyrene). Focusing on preclinical evidence from animal models cell-based studies, essential oils have been shown significantly enhance antioxidative enzyme activities, including superoxide dismutase, catalase, glutathione peroxidase, while also increasing levels of non-enzymatic antioxidants uric acid. Additionally, contribute restoration biochemical parameters, creatinine, acid, urea levels, mitigating damage reducing cell membrane injury, apoptosis, histopathological alterations. this evaluates protective benefits against models. underlying mechanism involved alleviating hepatorenal This underscores considerable promise candidates for medicinal applications functional foods or medicines, particularly preventing various overexposure.
Язык: Английский
Процитировано
0
Expert Opinion on Drug Delivery, Год журнала: 2024, Номер 21(10), С. 1415 - 1439
Опубликована: Сен. 14, 2024
Nucleic acid-based therapies are promising advancements in medicine. They offer unparalleled efficacy treating previously untreatable diseases through precise gene manipulation techniques. However, the challenge of achieving targeted delivery to specific cells remains a significant obstacle.
Язык: Английский
Процитировано
3
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(9), С. 10444 - 10461
Опубликована: Сен. 20, 2024
Hyaluronic acid (HA) is a naturally occurring, long, unbranched polysaccharide that plays critical role in maintaining skin structure and hydration. Its unique properties make it valuable component the field of nanopharmaceuticals. The combination HA into nanopharmaceuticals enhances its ability to interact with various therapeutic agents, improving delivery efficacy drugs. HA-based nanoparticles, including solid lipid polymeric nanogels, offer controlled release, enhanced stability, targeted agents. These innovations significantly improve outcomes reduce side effects, making an essential tool modern medicine. In general, HA-modified liposomes enhance drug encapsulation targeting, while nanoparticles (SLNs) provide core for encapsulation, offering release stability. This article provides overview potential applications recent advancements nanopharmaceuticals, emphasizing significant impact on evolving advanced strategies. By delving compatibility this review underscores promising revolutionizing
Язык: Английский
Процитировано
3
Vaccines, Год журнала: 2024, Номер 12(7), С. 764 - 764
Опубликована: Июль 12, 2024
COVID-19, generated by SARS-CoV-2, has significantly affected healthcare systems worldwide. The epidemic highlighted the urgent need for vaccine development. Besides conventional vaccination models, which include live-attenuated, recombinant protein, and inactivated vaccines, nanovaccines present a distinct opportunity to progress research offer convenient alternatives. This review highlights many widely used nanoparticle vectors, outlines their benefits drawbacks, examines recent developments in vaccines prevent SARS-CoV-2. It also offers thorough overview of advantages including an enhanced host immune response, multivalent antigen delivery, efficient drug delivery. main objective is provide reference development innovative antiviral vaccines.
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 136266 - 136266
Опубликована: Окт. 2, 2024
Язык: Английский
Процитировано
2