Targeting Ferroptosis as an Advance Strategy in Cancer Therapy
Antioxidants and Redox Signaling,
Год журнала:
2024,
Номер
41(10-12), С. 616 - 636
Опубликована: Июль 3, 2024
This
study
innovates
by
systematically
integrating
the
molecular
mechanisms
of
iron
death
and
its
application
in
cancer
therapy.
By
deeply
analyzing
interaction
between
tumor
microenvironment,
provides
a
new
theoretical
basis
for
treatment
directions
developing
more
effective
strategies.
In
addition,
points
to
critical
issues
barriers
that
need
be
addressed
future
research,
providing
valuable
insights
into
use
clinical
translation.
Язык: Английский
Mitochondria-targeted H2O2 homeostatic disruptors: Harnessing glutathione autoxidation and reversing GSDME “silencing” for ferroptotic and dual-pathway pyroptotic oncotherapy
Nano Today,
Год журнала:
2025,
Номер
61, С. 102640 - 102640
Опубликована: Янв. 14, 2025
Язык: Английский
Biomedical Micro/nanomotors: Driven mechanism, preparation and physiological barriers breakthrough
Coordination Chemistry Reviews,
Год журнала:
2025,
Номер
530, С. 216441 - 216441
Опубликована: Фев. 4, 2025
Язык: Английский
Antiprotein Corona-Fouling Effect of the Double-Stranded DNA Coating Layer on the Gold Nanoparticles-Small Molecule Adsorbent Probe
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 4, 2025
The
formation
of
a
protein
corona
(PC)
can
significantly
impact
the
detection
ability
gold
nanoparticles
(AuNPs)-small
molecule
adsorbent
probes
based
on
competitive
adsorption.
To
alleviate
this
problem,
in
study,
double-stranded
DNA
(dsDNA)
was
introduced
to
modify
AuNP
mitigate
negative
effect
PCs
small
molecules
by
taking
AuNPs-dichlorofluorescein
(DCF)
probe-based
ambroxol
hydrochloride
(AMB)
as
study
model.
It
found
that
dsDNA-modified
AuNPs-DCF
probe
(dsDNA@AuNPs-DCF),
accuracy
for
AMB
improved,
which
might
be
attributed
isolation
proteins
from
surface
AuNPs
while
still
allowing
access
due
introduction
rigid
dsDNA.
Further,
strand
length
and
number
dsDNA
modified
antifouling
performance
then
investigated,
it
LOD
value
artificial
milk
samples
dsDNA10bp90@AuNPs-DCF
(with
10
base
90:1
ratio
AuNPs)
is
decreased
more
than
2-fold
compared
with
probe.
Moreover,
probes,
recovery
rates
analyzed
commercial
greatly
improved
probe,
particularly
when
contained
much
lower
concentrations.
This
demonstrates
dsDNA-based
antiprotein
corona-fouling
strategy
AuNPs-small
provides
beneficial
ideas
dealing
interference
resulting
studying
biological
samples.
Язык: Английский
Polyphenol-based pH-responsive nanoparticles enhance chemo-immunotherapy in pancreatic cancer
Journal of Controlled Release,
Год журнала:
2025,
Номер
380, С. 615 - 629
Опубликована: Фев. 16, 2025
Язык: Английский
Advances in polymer nanomaterials targeting cGAS-STING pathway for enhanced cancer immunotherapy
Journal of Controlled Release,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Acidity-Unlocked Glucose Oxidase as Drug Vector to Boost Intratumor Copper Homeostatic Imbalance-Enhanced Cuproptosis for Metastasis Inhibition and Anti-Tumor Immunity
Biomaterials,
Год журнала:
2025,
Номер
319, С. 123207 - 123207
Опубликована: Фев. 28, 2025
Язык: Английский
Gradient-driven deep penetration of self-electrophoretic nanoparticles in acidic tumor microenvironments for enhanced antitumor therapy
Biomaterials,
Год журнала:
2025,
Номер
322, С. 123398 - 123398
Опубликована: Май 8, 2025
Язык: Английский
Inorganic Nanomedicine—Mediated Ferroptosis: A Synergistic Approach to Combined Cancer Therapies and Immunotherapy
Cancers,
Год журнала:
2024,
Номер
16(18), С. 3210 - 3210
Опубликована: Сен. 20, 2024
Ferroptosis,
a
form
of
regulated
cell
death
characterized
by
iron-dependent
lipid
peroxidation,
has
generated
substantial
interest
in
cancer
therapy.
Various
methods
have
been
developed
to
induce
ferroptosis
tumor
cells,
including
approved
drugs,
experimental
compounds,
and
nanomedicine
formulations.
Unlike
apoptosis,
presents
unique
molecular
cellular
features,
representing
promising
approach
for
cancers
resistant
conventional
treatments.
Recent
research
indicates
strong
link
between
the
immune
microenvironment,
suggesting
potential
trigger
robust
antitumor
responses.
Multiple
metabolic
pathways
control
ferroptosis,
iron,
lipid,
redox
metabolism.
Thus,
understanding
interaction
metabolism
is
crucial
developing
effective
anticancer
therapies.
This
review
provides
an
in-depth
discussion
on
combining
inorganic
nanoparticles
with
therapies
such
as
phototherapy,
chemotherapy,
radiotherapy,
immunotherapy,
role
these
combination
Furthermore,
this
paper
explores
future
treatment
using
nanomedicine,
focusing
how
can
enhance
cells
boost
immunity.
The
goal
advance
ferroptosis-based
from
laboratory
clinical
applications.
Язык: Английский