Bioceramic surface topography regulating immune osteogenesis

BME Frontiers, Год журнала: 2024, Номер 6

Опубликована: Дек. 27, 2024

Objective: This study aims to clarify the effects of bioceramic interface cues on macrophages. Impact Statement: Recently, there have been many researches exploring topography macrophage polarization and cytokine secretion. However, underlying mechanisms macrophages still need exploring. provides insights into micro-groove surface structures Introduction: With development bone tissue engineering methods, bioceramics used for repair. After implantation bioceramics, innate immune response that occurs at materials can deeply influence subsequent inflammation regeneration progress. Therefore, exploration regulation will be beneficial promote effects. Methods: In this study, with are fabricated by digital light processing 3-dimensional printing technology. Then, different spacings (0, 25, 50, 75 μm) prepared separately explore Results: The large spacing structure M2 osteoinductive secretion macrophage. reason is induce directional arrangement so as change phenotype Further show osteogenic differentiation mesenchymal stem cells, which benefit osteogenesis osteointegration. Conclusion: offers an effective application potential method

Язык: Английский

Metal-based biomaterials for treating bone diseases

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111140 - 111140

Опубликована: Март 1, 2025

Язык: Английский

An injectable hyaluronic acid/lithium calcium silicate soft tissue filler with vascularization and collagen regeneration

Bioactive Materials, Год журнала: 2024, Номер 44, С. 256 - 268

Опубликована: Окт. 23, 2024

Язык: Английский