Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 427 - 427

Опубликована: Март 27, 2025

Background: Postoperative adhesions are a common complication following abdominal surgery, affecting over 90% of patients and leading to significant morbidity. Current anti-adhesion strategies, such as the use physical chemical barriers, have limitations short retention time, mechanical fragility, inefficient drug delivery. This study developed pectin-based emulsion gel loaded with celecoxib prevent provide localized pain relief. Methods: Formulations (F1–F4) different pectin concentrations were evaluated for rheological properties, mucoadhesion, degradation rate, release. In vivo efficacy was in Sprague−Dawley rats via standardized model peritoneal abrasion, which formulations compared commercially available barrier. Results: The optimized (F4) exhibited improved mucoadhesion (9009 mPa·s), prolonged retention, controlled release 14 days, reaching 80% by day 9. vivo, formulation F4 significantly reduced product. Pharmacokinetic analysis showed rapid absorption (Tmax = 2 h) sustained plasma levels, confirming its effectiveness drug-delivery system. celecoxib-loaded successfully prevented postoperative provided Conclusions: These findings suggest potential clinical utility, though further preclinical evaluations required.

Язык: Английский