380 MPa-30% grade biodegradable Zn-Mn-Mg-Ca alloy: Bimodal grain structure, large work-hardening strain, and enhanced biocompatibility
Acta Biomaterialia,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Generating functional cardiac tissue for regenerative medicine applications: a 3D bioprinting approach
Regenerative Medicine,
Год журнала:
2025,
Номер
20(1), С. 11 - 15
Опубликована: Янв. 2, 2025
Язык: Английский
Dual-Responsive Methotrexate-Human Serum Albumin Complex-Encapsulated Liposomes for Targeted and Enhanced Atherosclerosis Therapy
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 2305 - 2322
Опубликована: Фев. 1, 2025
In
plaque
sites
of
atherosclerosis
(AS),
the
physiological
barrier
caused
by
thick
fiber
cap
due
to
overmigration
vascular
smooth
muscle
cells
(VSMCs)
prevents
efficient
drug
delivery
damaged
macrophages.
How
ensure
precise
targeted
drugs
and
their
on-demand
release
dysfunctional
under
fibrous
are
feasible
solutions
enhance
AS
treatment.
A
small
complex
methotrexate
(MTX)-human
serum
albumin
(HSA)
with
strong,
penetration
ability
was
encapsulated
in
a
cholesterol
hemisuccinate
(CHEM)
prepared
pH-sensitive
liposome,
modifying
ROS-responsive
PEG2000-TK-DSPE
(PTD),
termed
PTD/Lipo/MTX-HSA.
PTD/Lipo/MTX-HSA
can
achieve
targeting
response
plaques
environments
AS.
The
designed
formulation
accelerated
small-sized
MTX-HSA
excess
ROS
acidic
pH
conditions,
it
better
penetrated
macrophage
spheroids.
Furthermore,
has
mouse
model
produce
good
anti-inflammatory
efficacy
inhibiting
p65
entry
into
nucleus
turn
out
inflammatory
factor.
Our
formulations
work
safety
mind,
also
highlights
potential
precisely
on-demand-released
dual-responsive
smart
nanoplatforms
as
promising
therapeutic
options
penetrate
deeper
for
effective
treatment
Язык: Английский
Inorganic Biomaterials Inducing Scaffolds Pre‐Neuralization for Infarcted Myocardium Repair
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 24, 2025
Abstract
Neural
networks
are
found
to
play
an
important
role
in
monitoring
and
coordinating
cardiac
physiological
activities.
However,
the
clinical
use
of
neuroregulatory
strategies
for
repairing
infarcted
myocardium,
such
as
vagus
nerve
stimulation
pharmacological
activation,
confronts
challenges
managing
signals
potential
drug
side
effects.
In
this
study,
innovative
myocardial
infarction
repair
strategy
by
creating
a
“pre‐neuralized”
scaffold
that
combines
strontium
silicate
microparticles
with
neural
stem
cells
(NSCs)
is
introduced.
Strontium
promotes
NSCs
differentiation,
resulting
enriched
mature
neurons.
This
exhibits
capabilities
enhance
maturation
synchronized
contraction
cardiomyocytes,
facilitating
improving
function
vivo.
The
findings
indicate
pre‐neuralized
aids
recovery
modulating
genes
linked
circadian
rhythm,
underscoring
strategic
benefit
neural‐induced
regulation
tissue
repair.
conclusion,
study
presents
promising
approach
myocardium
using
inorganic
biomaterial‐induced
scaffolds
neuromodulatory
properties
from
perspective
systemically
regulation.
work
may
offer
new
addressing
complex
organ
injuries.
Язык: Английский
How Advanced are Conductive Nanocomposite Hydrogels for Repairing and Monitoring Myocardial Infarction?
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 6777 - 6812
Опубликована: Май 1, 2025
Myocardial
infarction
(MI)
remains
the
leading
cause
of
death
worldwide.
Cardiomyocytes,
being
terminally
differentiated
cells,
have
limited
regenerative
capacity.
Following
an
MI,
myocyte
necrosis
and
ventricular
dilation
can
lead
to
heart
failure.
While
current
treatments
for
disease-such
as
pharmaceuticals,
coronary
interventions,
artery
bypass
grafting,
cellular
therapy,
transplantation-offer
some
relief,
their
effectiveness
is
limited,
particularly
in
patients
with
severe
myocardial
damage.
Recent
advancements
cardiac
tissue
engineering
introduced
a
range
materials
aimed
at
repairing
heart,
conductive
hydrogels
emerging
promising
approach.
These
materials,
which
include
metallic
nanomaterials,
polymers,
carbon-based
other
specialized
types
substances,
exhibit
excellent
electrical
conductivity,
tunable
mechanical
properties,
biomimetic
features.
As
result,
they
are
increasingly
considered
repair.
This
review
explores
application
treating
infarction,
highlighting
recent
research
various
hydrogels.
categorized
by
nanomaterial
composition,
including
designed
cell
culture
scaffolds,
patch-type
hydrogels,
injectable
Additionally,
electrophysiological
monitoring
during
MI
gaining
importance
understanding
disease
progression
prognosis.
In
years,
rapidly
evolved
serve
tools
real-time
signal
changes,
while
electroresponsive
properties
open
new
possibilities
targeted
drug
delivery
infarct
therapy.
Язык: Английский