Polymeric microgels: Synthesis, and emerging biomedical applications
Journal of Macromolecular Science Part A,
Год журнала:
2025,
Номер
unknown, С. 1 - 22
Опубликована: Март 3, 2025
Язык: Английский
Intelligent Nanomaterials Design for Osteoarthritis Managements
Small Methods,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 30, 2025
Osteoarthritis
(OA)
is
the
most
prevalent
degenerative
joint
disorder,
characterized
by
progressive
degradation,
pain,
and
diminished
mobility,
all
of
which
collectively
impair
patients'
quality
life
escalate
healthcare
expenditures.
Current
treatment
options
are
often
inadequate
due
to
limited
efficacy,
adverse
side
effects,
temporary
symptom
relief,
underscoring
urgent
need
for
more
effective
therapeutic
strategies.
Recent
advancements
in
nanomaterials
nanomedicines
offer
promising
solutions
improving
drug
bioavailability,
reducing
effects
providing
targeted
benefits.
This
review
critically
examines
pathogenesis
OA,
highlights
limitations
existing
treatments,
explores
latest
innovations
intelligent
design
OA
therapy,
with
an
emphasis
on
their
engineered
properties,
mechanisms,
translational
potential
clinical
application.
By
compiling
recent
findings,
this
work
aims
inspire
further
exploration
innovation
nanomedicine,
ultimately
advancing
development
personalized
therapies.
Язык: Английский
Current Status and Perspectives of Research on Polymer Hydrogels in the Treatment and Protection of Osteoarthritis
Macromolecular Bioscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Abstract
Arthritis
is
a
degenerative
disease
characterized
by
chronic
cartilage
degeneration.
It
affects
hundreds
of
millions
people
worldwide
and
often
has
serious
consequences
such
as
joint
pain
swelling,
limited
mobility,
deformity.
However,
conventional
treatments
still
struggle
to
achieve
satisfactory
results.
Finding
more
effective
for
arthritis
remains
an
important
clinical
challenge.
As
hydrogels
have
unique
3D
spatial
mesh
structure,
significant
material
interaction
ability,
adjustable
mechanical
properties,
good
biodegradability,
they
can
provide
suitable
cellular
or
tissue
microenvironment,
their
potential
in
scaffolding
effect,
lubrication,
anti‐inflammatory
drug
delivery
expected
be
potent
therapeutic
approach
the
treatment
osteoarthritis.
In
this
review,
three
aspects
hydrogel
products
osteoarthritis
are
comprehensively
summarized
discussed,
namely,
selection
gel
design,
exploration
cross‐linking
mechanisms,
mechanisms
therapy
osteoarthritis,
focus
on
advantages
limitations
applications,
which
point
out
direction
development
strategy
innovative
field,
applied
research,
transformation.
Язык: Английский