Prenatal methadone exposure produces functional and molecular alterations in the basolateral amygdala and decreased voluntary ethanol intake in female, but not male offspring DOI Creative Commons
Meredith E. Gamble,

María del Pilar del Fidalgo Montero,

David Silberstein

и другие.

Frontiers in Behavioral Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Апрель 15, 2025

Introduction A result of the ongoing opioid epidemic has been a significant rise in rates use during pregnancy. This includes maintenance medications for disorder (MOUDs), such as methadone, which are standard care pregnant people with an (OUD). Although MOUDs leads to better neonatal outcomes exposed offspring compared those born from individuals untreated OUD, pharmacology is similar misused opioids. Despite high prevalence prenatal exposure opioids, including MOUDs, our understanding long-term consequences these exposures limited. Prenatal drug known be risk factor future substance and mood disorders, yet, how influences ethanol intake adult associated affective behaviors not examined. Methods Using rat model methadone (PME), included twice daily injections gestational day 3-20, this study assessed forced swim stress (FSS) altered intake, addition examination depressive-like behavior FSS. Given role basolateral amygdala (BLA) emotion reward processing, we also conducted patch clamp electrophysiology experiments BLA neurons investigate changes synaptic transmission gene expression neuromodulatory systems that influence processing. Results Females history PME consumed less than control females, no effects on evident males. While increased immobility FSS both males had intake. glutamate dopamine D1, D2, D3 receptor mu mRNA but Discussion Collectively, identified impairments alterations function females PME, supporting previous findings lab demonstrating female more sensitive PME.

Язык: Английский

Advances in animal models of prenatal opioid exposure DOI Creative Commons
Julia Ferrante, Julie A. Blendy

Trends in Neurosciences, Год журнала: 2024, Номер 47(5), С. 367 - 382

Опубликована: Апрель 12, 2024

Neonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The complexity of in utero exposure clinical studies makes it difficult to investigate underlying mechanisms that could ultimately inform early diagnosis and treatments. Clinical are unable dissociate the influence maternal polypharmacy or environment from direct effects exposure, highlighting need for effective animal models. Early models prenatal primarily used prototypical opioid, morphine, was often limited narrow period during gestation. In recent years, number preclinical has grown rapidly. Newer utilize both prescription nonprescription opioids vary onset duration exposure. this review, we summarize novel developed years attempt reconcile results between while critically identifying gaps within current literature.

Язык: Английский

Процитировано

6
Opioid Receptor Signaling Throughout Ontogeny: Shaping Neural and Behavioral Trajectories DOI

Mary B. Spodnick,

Shannon C McElderry,

Marvin R. Diaz

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер 170, С. 106033 - 106033

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Prenatal methadone exposure produces functional and molecular alterations in the basolateral amygdala and decreased voluntary ethanol intake in female, but not male offspring DOI Creative Commons
Meredith E. Gamble,

María del Pilar del Fidalgo Montero,

David Silberstein

и другие.

Frontiers in Behavioral Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Апрель 15, 2025

Introduction A result of the ongoing opioid epidemic has been a significant rise in rates use during pregnancy. This includes maintenance medications for disorder (MOUDs), such as methadone, which are standard care pregnant people with an (OUD). Although MOUDs leads to better neonatal outcomes exposed offspring compared those born from individuals untreated OUD, pharmacology is similar misused opioids. Despite high prevalence prenatal exposure opioids, including MOUDs, our understanding long-term consequences these exposures limited. Prenatal drug known be risk factor future substance and mood disorders, yet, how influences ethanol intake adult associated affective behaviors not examined. Methods Using rat model methadone (PME), included twice daily injections gestational day 3-20, this study assessed forced swim stress (FSS) altered intake, addition examination depressive-like behavior FSS. Given role basolateral amygdala (BLA) emotion reward processing, we also conducted patch clamp electrophysiology experiments BLA neurons investigate changes synaptic transmission gene expression neuromodulatory systems that influence processing. Results Females history PME consumed less than control females, no effects on evident males. While increased immobility FSS both males had intake. glutamate dopamine D1, D2, D3 receptor mu mRNA but Discussion Collectively, identified impairments alterations function females PME, supporting previous findings lab demonstrating female more sensitive PME.

Язык: Английский

Процитировано

0