Exploring the effects of adolescent social isolation stress on the serotonin system and ethanol-motivated behaviors
Bryan D. McElroy,
Chen Li,
Nicholas McCloskey
и другие.
Psychopharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 4, 2025
Abstract
Rationale
Alcohol
is
one
of
the
most
frequently
used
drugs
abuse
and
has
a
major
impact
on
human
health
worldwide.
People
assigned
female
at
birth
those
with
adverse
childhood
experiences
are
stress-vulnerable
more
likely
to
report
drinking
as
means
“self-medication.”
Prior
studies
in
our
laboratory
showed
that
adolescent
social
isolation
stress
(SIS)
increases
vulnerability
ethanol
(EtOH)
intake
consumption
despite
negative
consequences
rats.
Objectives
Here,
we
explored
modulation
dorsal
raphe
nucleus
(DRN)-serotonin
(5-HT)
system,
sexually
dimorphic
neurotransmitter
system
involved
stress-reward
interactions,
determine
its
contribution
EtOH-motivated
behaviors
rats
have
undergone
SIS.
Results
We
employed
electrophysiological
functional
neuroanatomy
strategies
show
both
SIS
EtOH
exposure
induce
persistent
hypofunction
DRN
5-HT
particularly
females.
Chemogenetic
activation
neurons
attenuated
reward
value
for
sucrose
elevated
punished
responding
stress-dependent
manner.
Conclusions
Our
results
highlight
an
inverse
relationship
between
sex-
nature
this
relationship,
connection
signaling
acute
rewards
punishment.
These
data
support
potential
target
treat
aberrant
alcohol
populations.
Язык: Английский
Effects of social isolation on locus coeruleus opioid receptor expression and affective behavior.
John A. Tkaczynski,
Jordan Riser,
Maya Patel
и другие.
Neurobiology of Stress,
Год журнала:
2025,
Номер
unknown, С. 100717 - 100717
Опубликована: Март 1, 2025
Язык: Английский
Voluntary adolescent alcohol exposure does not increase adulthood consumption of alcohol in multiple mouse and rat models
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 1, 2024
Adolescence
is
a
period
of
increased
risk
taking,
including
alcohol
and
drug
use.
Multiple
clinical
studies
report
positive
relationship
between
adolescent
consumption
developing
an
use
disorder
(AUD)
in
adulthood.
However,
few
preclinical
have
attempted
to
tease
apart
the
biological
contributions
exposure,
independent
other
social,
environmental,
stress
factors,
that
been
conducted
show
mixed
results.
Here
we
several
voluntary
models,
across
four
labs
three
institutes
with
two
rodent
species,
investigate
ramifications
on
adulthood
controlled,
pre-clinical
environments.
We
consistently
demonstrate
lack
robust
increases
consumption.
This
work
highlights
risks
seen
both
human
datasets
murine
drinking
models
may
be
due
unique
social
environmental
factors
-
some
which
humans.
Язык: Английский
Effects of early social isolation and adolescent single prolonged stress on anxiety‐like behaviors and voluntary ethanol consumption in female Long Evans rats
Alcohol Clinical and Experimental Research,
Год журнала:
2024,
Номер
48(8), С. 1586 - 1599
Опубликована: Июнь 20, 2024
Exposure
to
stress
during
childhood
and
adolescence
is
a
risk
factor
for
alcohol
use
disorder
(AUD)
comorbid
conditions,
including
posttraumatic
(PTSD).
We
previously
established
an
adolescent
social
isolation
(SI)
model
that
leads
the
emergence
of
wide
range
behavioral
factors
AUD,
increased
anxiety-like
behavior,
locomotor
activity,
ethanol
consumption
in
male
female
rats.
Here,
we
sought
test
hypothesis
SI
may
increase
vulnerability
single
prolonged
(SPS),
rodent
PTSD.
Язык: Английский
Is the Relationship Between Adolescent Social Isolation and Anxiety‐Like Behaviors Altered by Microglia Ablation in Female Long Evans Rats?
Brain and Behavior,
Год журнала:
2025,
Номер
15(3)
Опубликована: Март 1, 2025
Despite
extensive,
cross-disciplinary
research
revealing
a
relationship
between
early
life
stress
(ELS)
and
an
increased
risk
for
neuropsychiatric
disorders,
the
underlying
processes
mediating
this
are
not
fully
understood.
Further,
majority
of
preclinical
studies
investigating
have
taken
sex
differences
into
consideration.
A
growing
body
work
suggests
that
microglia,
resident
immune
cells
brain,
impacted
by
ELS
contribute
to
some
maladaptive
behavioral
phenotypes
in
adulthood.
Here,
we
utilized
adolescent
social
isolation
(aSI)
model
female
rats
test
role
microglia
effects
on
anxiety-related
behaviors.
The
present
study
sought
determine
whether
ablation
during
aSI
could
prevent
anxiety-like
behaviors
Long
Evans
rats.
colony-stimulating
factor
1
receptor
(CSF1-r)
inhibitor,
PLX3397,
was
provided
chow
ablate
at
start
period
(postnatal
day
(P)
21-42).
During
period,
animals
performed
battery
assays
including
open
field
test,
elevated
plus
maze,
successive
alleys
test.
Following
completion
assays,
brain
tissue
collected
confirm
efficacy
PLX3397
identify
changes
population
density.
Relative
group-housed
(GH)
controls,
showed
locomotor
activity
higher
closed-arm
entries
maze.
Although
effectively
ablated
across
all
animals,
treatment
had
minimal
observed
aSI-associated
phenotypes.
Together,
these
data
suggest
required
adaptations
promoted
aSI.
Future
will
be
needed
assess
Язык: Английский
Voluntary adolescent alcohol exposure does not robustly increase adulthood consumption of alcohol in multiple mouse and rat models
Addiction Neuroscience,
Год журнала:
2024,
Номер
12, С. 100171 - 100171
Опубликована: Авг. 3, 2024
Adolescence
is
a
period
of
increased
risk
taking,
including
alcohol
and
drug
use.
Multiple
clinical
studies
report
positive
relationship
between
adolescent
consumption
developing
an
use
disorder
(AUD)
in
adulthood.
However,
few
preclinical
have
attempted
to
tease
apart
the
biological
contributions
exposure,
independent
other
social,
environmental,
stress
factors,
that
been
conducted
show
mixed
results.
Here
we
several
voluntary
models,
across
four
labs
three
institutes
with
two
rodent
species,
investigate
ramifications
on
adulthood
controlled,
pre-clinical
environments.
We
consistently
demonstrate
lack
robust
increases
consumption.
This
work
highlights
risks
seen
both
human
datasets
murine
drinking
models
may
be
due
unique
social
environmental
factors
-
some
which
humans.
Язык: Английский
Crocin has a greater therapeutic role in the restoration of behavioral impairments caused by maternal social isolation in adolescent than in adult offspring probably through GSK-3beta downregulation
Learning and Motivation,
Год журнала:
2024,
Номер
88, С. 102060 - 102060
Опубликована: Окт. 23, 2024
Язык: Английский
Sex-specific changes in voluntary alcohol consumption and nucleus accumbens synaptic plasticity in C57BL/6J mice exposed to neonatal maternal separation
Neuropharmacology,
Год журнала:
2024,
Номер
262, С. 110212 - 110212
Опубликована: Ноя. 7, 2024
The
long-term
influence
of
early-life
stress
on
brain
neurophysiology
has
been
extensively
investigated
using
different
animal
models.
Among
these,
repeated
maternal
separation
(RMS)
in
rodents
is
one
the
most
commonly
adopted.
In
this
study,
we
elucidated
long-lasting
effects
exposure
to
postnatal
RMS
C57BL/6J
adult
mice
voluntary
alcohol
consumption
and
nucleus
accumbens
(NAc)
neurophysiology.
Mice
were
separated
from
their
dam
for
360
min
daily
day
2
(PND2)
PND17,
experiments
then
performed
(PND60)
animals.
addition,
as
recent
evidence
showed
that
circulating
estrogens
may
play
a
protective
role
against
function,
including
organization
activation
neuronal
structures,
also
evaluated
effect
single
injection
β-estradiol
3-benzoate
(EB)
at
PND2,
which
known
disrupt
male
sex
differentiation,
mice.
was
associated
with
an
increased
preference
mice,
but
not
female
or
treated
EB.
Patch
clamp
conducted
NAc
medium
spiny
neurons
(MSNs)
revealed
excitatory
inhibitory
synaptic
transmission
plasticity
glutamatergic
synapses
significantly
impaired
exposed
protocol.
This
again
prevented
Our
findings
strengthen
idea
sex-dependent
modifications
areas
involved
goal-directed
behavior
intake.
Язык: Английский
Effects of Social Isolation on Locus Coeruleus Opioid Receptor Expression and Affective Behavior
John A. Tkaczynski,
Jordan Riser,
Maya Patel
и другие.
Опубликована: Янв. 1, 2024
Язык: Английский
Hippocampal Viral-Mediated Urokinase Plasminogen Activator (uPA) Overexpression Mitigates Stress-Induced Anxiety and Depression in Rats by Increasing Brain-Derived Neurotrophic Factor (BDNF) Levels
Biomolecules,
Год журнала:
2024,
Номер
14(12), С. 1603 - 1603
Опубликована: Дек. 15, 2024
Emerging
evidence
suggests
the
serine
protease,
urokinase
plasminogen
activator
(uPA),
may
play
an
important
role
in
modulation
of
mood
and
cognitive
functions.
Also,
preliminary
indicates
that
uPA
modulates
BDNF
activity
is
known
to
be
involved
pathogenesis
disorders.
However,
physiological
functions
specific
brain
regions
for
mediating
stress-related
emotional
behaviors
remain
elucidated.
Therefore,
aim
this
study
was
assess
ectopic
expression
on
anxiety-
depression-like
following
social
defeat
stress
rats.
For
purpose,
we
inspected
behavioral
outcomes
bilateral
stereotaxic
delivery
uPA-overexpressing
lentiviral
vectors
hippocampus
using
a
series
tests.
Results
show
hippocampal
gain-of-function
prevented
stress-elicited
anxiogenic-like
effects,
as
determined
marble
burying,
open
field,
elevated
plus
maze
tests,
with
no
alterations
spontaneous
locomotor
activity.
overexpression
resulted
anti-depressant-like
effects
sucrose
splash,
tail
suspension,
forced
swim
Most
importantly,
increased
levels,
strong
positive
correlation
found
Pearson
test.
Moreover,
same
analysis
revealed
negative
relationship
between
mRNA
parameters
behaviors.
Taken
together,
work
highlights
importance
considering
activation
provides
new
insights
into
mechanisms
pathophysiology
illnesses,
which
should
help
development
approaches
tackle
depression
anxiety
Язык: Английский