Investigation of the Effect of Preparation Parameters on the Structural and Mechanical Properties of Gelatin/Elastin/Sodium Hyaluronate Scaffolds Fabricated by the Combined Foaming and Freeze-Drying Techniques DOI Open Access

Mansour T. Qamash,

S. Misagh Imani,

Meisam Omidi

и другие.

Journal of Composites Science, Год журнала: 2024, Номер 8(10), С. 408 - 408

Опубликована: Окт. 4, 2024

This paper aimed to evaluate the effects of different preparation parameters, including agitation speed, time, and chilling temperature, on structural mechanical properties a novel gelatin/elastin/sodium hyaluronate tissue engineering scaffold, recently developed by our research group. Fabricated using combination foaming freeze-drying techniques, scaffolds were assessed understand how these parameters influence their morphology, internal microstructure, porosity, properties, degradation behavior. The fabrication process used in this study involved preparing homogeneous aqueous solution containing 8% gelatin, 2% elastin, 0.5% sodium (w/v), which was then subjected at speeds 500, 1000, 1500 rpm for durations 5, 15, 25 min. mixture subsequently frozen −20 °C −80 °C, followed cross-linking. Morphological analyses laser microscopy scanning electron (SEM) demonstrated that had pore sizes ranging from 100 300 µm, are conducive effective cell interaction regeneration. confirmed efficacy combined method creating highly interconnected porous structures. Our findings indicated temperature slightly influenced size. In contrast, higher longer duration times led increased porosity rate but decreased modulus. Mathematical estimators compressive modulus statistical analysis parameters. validated experimentally, with error between estimated experimental values being less than 6% 21%

Язык: Английский

Magnetic Substrates for Tissue Engineering—A Review DOI Creative Commons
Tomasz Błachowicz, Andrea Ehrmann

Magnetochemistry, Год журнала: 2024, Номер 10(8), С. 52 - 52

Опубликована: Июль 24, 2024

Tissue engineering is based on combining cells with suitable scaffolds and growth factors. Recently, bone tissue has been especially investigated deeply due to a large number of bone-related diseases. One approach improve using piezoelectric materials as way influence the growing by mechanical stress. Another method stimulate applying an external magnetic field composites magnetostrictive materials, well possibility prepare oriented surfaces orienting embedded fibers or nanoparticles. In addition, without other special properties have also reported show improved for engineering. Here, we provide overview recent research engineering, differentiating between We advantages scaffolds, related cell guidance differentiation, report progress in production application such substrates different areas

Язык: Английский

Процитировано

0
Investigation of the Effect of Preparation Parameters on the Structural and Mechanical Properties of Gelatin/Elastin/Sodium Hyaluronate Scaffolds Fabricated by the Combined Foaming and Freeze-Drying Techniques DOI Open Access

Mansour T. Qamash,

S. Misagh Imani,

Meisam Omidi

и другие.

Journal of Composites Science, Год журнала: 2024, Номер 8(10), С. 408 - 408

Опубликована: Окт. 4, 2024

This paper aimed to evaluate the effects of different preparation parameters, including agitation speed, time, and chilling temperature, on structural mechanical properties a novel gelatin/elastin/sodium hyaluronate tissue engineering scaffold, recently developed by our research group. Fabricated using combination foaming freeze-drying techniques, scaffolds were assessed understand how these parameters influence their morphology, internal microstructure, porosity, properties, degradation behavior. The fabrication process used in this study involved preparing homogeneous aqueous solution containing 8% gelatin, 2% elastin, 0.5% sodium (w/v), which was then subjected at speeds 500, 1000, 1500 rpm for durations 5, 15, 25 min. mixture subsequently frozen −20 °C −80 °C, followed cross-linking. Morphological analyses laser microscopy scanning electron (SEM) demonstrated that had pore sizes ranging from 100 300 µm, are conducive effective cell interaction regeneration. confirmed efficacy combined method creating highly interconnected porous structures. Our findings indicated temperature slightly influenced size. In contrast, higher longer duration times led increased porosity rate but decreased modulus. Mathematical estimators compressive modulus statistical analysis parameters. validated experimentally, with error between estimated experimental values being less than 6% 21%

Язык: Английский

Процитировано

0