Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications

Chemical Reviews, Год журнала: 2019, Номер 119(8), С. 5298 - 5415

Опубликована: Март 27, 2019

Electrospinning is a versatile and viable technique for generating ultrathin fibers. Remarkable progress has been made with regard to the development of electrospinning methods engineering electrospun nanofibers suit or enable various applications. We aim provide comprehensive overview electrospinning, including principle, methods, materials, begin brief introduction early history followed by discussion its principle typical apparatus. then discuss renaissance over past two decades as powerful technology production diversified compositions, structures, properties. Afterward, we applications nanofibers, their use "smart" mats, filtration membranes, catalytic supports, energy harvesting/conversion/storage components, photonic electronic devices, well biomedical scaffolds. highlight most relevant recent advances related focusing on representative examples. also offer perspectives challenges, opportunities, new directions future development. At end, approaches scale-up briefly types commercial products based that have found widespread in our everyday life.

Язык: Английский

---

Drug Delivery Applications of Core-Sheath Nanofibers Prepared by Coaxial Electrospinning: A Review

Pharmaceutics, Год журнала: 2019, Номер 11(7), С. 305 - 305

Опубликована: Июль 1, 2019

Electrospinning has emerged as one of the potential techniques for producing nanofibers. The use electrospun nanofibers in drug delivery increased rapidly over recent years due to their valuable properties, which include a large surface area, high porosity, small pore size, superior mechanical and ease modification. A loaded nanofiber membrane can be prepared via electrospinning using model polymer solution; however, release from safe controlled way is challenging result initial burst release. Employing core-sheath design provides promising solution controlling Numerous studies have reported on preparation by coaxial applications. This paper summarizes physical phenomena, effects various parameters electrospinning, usefulness delivery. Furthermore, this report also highlights future challenges involved utilizing

Язык: Английский

---

Recent advances in PLGA-based biomaterials for bone tissue regeneration

Acta Biomaterialia, Год журнала: 2021, Номер 127, С. 56 - 79

Опубликована: Апрель 6, 2021

Язык: Английский

---

Advances in Functional Polymer Nanofibers: From Spinning Fabrication Techniques to Recent Biomedical Applications

ACS Applied Materials & Interfaces, Год журнала: 2020, Номер 12(41), С. 45673 - 45701

Опубликована: Сен. 16, 2020

Functional polymeric micro-/nanofibers have emerged as promising materials for the construction of structures potentially useful in biomedical fields. Among all kinds technologies to produce polymer fibers, spinning methods gained considerable attention. Herein, we provide a recent review on advances design micro- and nanofibrous platforms via techniques applications. Specifically, emphasize electrospinning, solution blow spinning, centrifugal microfluidic approaches. We first introduce fundamentals these then highlight potential applications such nanostructured fibers drug delivery, tissue engineering, regenerative medicine, disease modeling, sensing/biosensing. Finally, outline current challenges future perspectives practical field.

Язык: Английский

---

Electrospun Nanofibrous Materials for Wound Healing

Advanced Fiber Materials, Год журнала: 2020, Номер 2(4), С. 212 - 227

Опубликована: Март 21, 2020

Язык: Английский

---

Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release

Pharmaceutics, Год журнала: 2019, Номер 11(4), С. 182 - 182

Опубликована: Апрель 15, 2019

Electrospinning technologies have been applied in the field of tissue engineering as materials, with nanoscale-structures and high porosity, can be easily prepared via this method to bio-mimic natural extracellular matrix (ECM). Tissue aims fabricate functional biomaterials for repairment regeneration defective tissue. In addition structural simulation accelerating repair process achieving a high-quality regeneration, combination bioactive molecules is required an ideal tissue-engineering scaffold. Due diversity materials selection electrospinning, great flexibility drug delivery systems achieved. Various drugs including antibiotic agents, vitamins, peptides, proteins incorporated into electrospun scaffolds using different electrospinning techniques drug-loading methods. This review recent research on nanofibrous applications, development preparation methods, various molecules. These studies are based fabrication blood vessels, nerve tissues, cartilage, bone defects, treatment aneurysms skin wounds, well their applications related oral mucosa dental fields. these studies, due optimal loading methods vitro vivo experiments demonstrated that exhibited desirable effects damaged and, thus, excellent potential clinical application.

Язык: Английский

---

Scale‐up of electrospinning technology: Applications in the pharmaceutical industry

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2019, Номер 12(4)

Опубликована: Дек. 20, 2019

Abstract Recently, electrospinning (ES) of fibers has been shown to be an attractive strategy for drug delivery. One the main features ES is that a wide variety drugs can loaded into improve their bioavailability, enhance dissolution, or achieve controlled release. Besides, continuous technology with low energy consumption, which make it very economic production alternative widely used freeze drying and spray drying. However, rate laboratory‐scaled limited industrial application so far. This article covers various technologies developed scaled‐up fiber emphasis on pharmaceutically relevant examples. The methods increasing productivity are complied, followed by review specific examples from literature where these utilized produce oral delivery systems. different compared in terms basic principles, advantages, limitations. Finally, downstream processing options prepare tablets capsules containing electrospun covered as well. categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies

Язык: Английский

---

Electrospun nanofibers promote wound healing: theories, techniques, and perspectives

Journal of Materials Chemistry B, Год журнала: 2021, Номер 9(14), С. 3106 - 3130

Опубликована: Янв. 1, 2021

We provides a review on how electrospun nanofiber scaffolds promote wound healing and the technology has been used for fabricating multi-functional that have greatly promoted development of dressings.

Язык: Английский

---

Electrospinning approach for nanoencapsulation of bioactive compounds; recent advances and innovations

Trends in Food Science & Technology, Год журнала: 2020, Номер 100, С. 190 - 209

Опубликована: Апрель 24, 2020

Язык: Английский

---

From Arteries to Capillaries: Approaches to Engineering Human Vasculature

Advanced Functional Materials, Год журнала: 2020, Номер 30(37)

Опубликована: Июнь 11, 2020

From micro-scaled capillaries to millimeter-sized arteries and veins, human vasculature spans multiple scales cell types. The convergence of bioengineering, materials science, stem biology has enabled tissue engineers recreate the structure function different hierarchical levels vascular tree. Engineering large-scale vessels been pursued over past thirty years replace or bypass damaged arteries, arterioles, venules, their routine application in clinic may become a reality near future. Strategies engineer meso- microvasculature have extensively explored generate models study biology, drug transport, disease progression, as well for vascularizing engineered tissues regenerative medicine. However, bioengineering whole organs transplantation, failed result clinical translation due lack proper integrated effective oxygen nutrient delivery. development strategies multi-scale networks direct anastomosis host would greatly benefit this formidable goal. In review, we discuss design considerations technologies engineering millimeter-, meso-, micro-scale vessels. We further provide examples recent state-of-the-art vasculature. Finally, identify key challenges limiting vascularized offer our perspective on future directions exploration.

Язык: Английский

---