Seminars in Immunology,
Год журнала:
2020,
Номер
50, С. 101426 - 101426
Опубликована: Авг. 1, 2020
In
the
last
decade
there
have
been
some
significant
advances
in
vaccine
adjuvants,
particularly
relation
to
their
inclusion
licensed
products.
This
was
proceeded
by
several
decades
which
such
were
very
scarce,
or
entirely
absent,
but
novel
adjuvants
now
included
products,
including
US.
These
relied
upon
key
technological
insights
that
emerged
this
time
period,
finally
allowed
an
depth
understanding
of
how
work.
include
developments
systems
biology
approaches
allow
hypotheses
first
advanced
pre-clinical
studies
be
critically
evaluated
human
studies.
review
highlights
these
recent
advances,
both
themselves,
also
technologies
enabled
successes.
Moreover,
we
appraise
what
will
come
next,
terms
new
adjuvant
molecules,
and
needed
them
succeed.
We
confidently
predict
additional
emerge
coming
years
reach
approval
components
might
differ
significantly
from
those
are
currently
used.
Gradually,
natural
products
originally
used
build
since
they
readily
available
at
initial
development,
replaced
synthetic
biosynthetic
materials,
with
more
appealing
attributes,
reliable
robust
supply,
along
reduced
heterogeneity.
The
advance
is
timely,
given
need
create
vaccines
deal
COVID-19
pandemic.
Although,
must
ensure
rigorous
safety
evaluations
current
not
‘short-changed’
push
for
meet
global
challenge
as
quickly
possible,
jeopardize
achieved,
pushing
less
established
too
quickly,
if
data
does
fully
support
it.
Chemical Reviews,
Год журнала:
2021,
Номер
121(18), С. 11385 - 11457
Опубликована: Май 3, 2021
Advances
in
hydrogel
technology
have
unlocked
unique
and
valuable
capabilities
that
are
being
applied
to
a
diverse
set
of
translational
applications.
Hydrogels
perform
functions
relevant
range
biomedical
purposes-they
can
deliver
drugs
or
cells,
regenerate
hard
soft
tissues,
adhere
wet
prevent
bleeding,
provide
contrast
during
imaging,
protect
tissues
organs
radiotherapy,
improve
the
biocompatibility
medical
implants.
These
make
hydrogels
useful
for
many
distinct
pressing
diseases
conditions
even
less
conventional
areas
such
as
environmental
engineering.
In
this
review,
we
cover
major
hydrogels,
with
focus
on
novel
benefits
injectable
how
they
relate
applications
medicine
environment.
We
pay
close
attention
development
contemporary
requires
extensive
interdisciplinary
collaboration
accomplish
highly
specific
complex
biological
tasks
from
cancer
immunotherapy
tissue
engineering
vaccination.
complement
our
discussion
preclinical
clinical
mechanical
design
considerations
needed
scaling
technologies
application.
anticipate
readers
will
gain
more
complete
picture
expansive
possibilities
practical
impactful
differences
across
numerous
fields
Chemical Reviews,
Год журнала:
2022,
Номер
122(6), С. 5977 - 6039
Опубликована: Фев. 2, 2022
The
stimulator
of
interferon
genes
(STING)
cellular
signaling
pathway
is
a
promising
target
for
cancer
immunotherapy.
Activation
the
intracellular
STING
protein
triggers
production
multifaceted
array
immunostimulatory
molecules,
which,
in
proper
context,
can
drive
dendritic
cell
maturation,
antitumor
macrophage
polarization,
T
priming
and
activation,
natural
killer
vascular
reprogramming,
and/or
death,
resulting
immune-mediated
tumor
elimination
generation
immune
memory.
Accordingly,
there
significant
amount
ongoing
preclinical
clinical
research
toward
further
understanding
role
surveillance
as
well
development
modulators
strategy
to
stimulate
immunity.
Yet,
efficacy
agonists
limited
by
many
drug
delivery
pharmacological
challenges.
Depending
on
class
agonist
desired
administration
route,
these
may
include
poor
stability,
immunocellular
toxicity,
immune-related
adverse
events,
or
lymph
node
targeting
retention,
low
uptake
delivery,
complex
dependence
magnitude
kinetics
signaling.
This
review
provides
concise
summary
pathway,
highlighting
recent
biological
developments,
immunological
consequences,
implications
delivery.
also
offers
critical
analysis
an
expanding
arsenal
chemical
strategies
that
are
being
employed
enhance
efficacy,
safety,
utility
lastly
draws
attention
several
opportunities
therapeutic
advancements.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2700 - 2700
Опубликована: Янв. 31, 2023
mRNA
vaccines
have
been
demonstrated
as
a
powerful
alternative
to
traditional
conventional
because
of
their
high
potency,
safety
and
efficacy,
capacity
for
rapid
clinical
development,
potential
rapid,
low-cost
manufacturing.
These
progressed
from
being
mere
curiosity
emerging
COVID-19
pandemic
vaccine
front-runners.
The
advancements
in
the
field
nanotechnology
developing
delivery
vehicles
are
highly
significant.
In
this
review
we
summarized
each
every
aspect
vaccine.
article
describes
structure,
its
pharmacological
function
immunity
induction,
lipid
nanoparticles
(LNPs),
upstream,
downstream,
formulation
process
Additionally,
trials
also
described.
A
deep
dive
into
future
perspectives
vaccines,
such
freeze-drying,
systems,
LNPs
targeting
antigen-presenting
cells
dendritic
cells,
summarized.
