Annual Review of Biomedical Engineering,
Год журнала:
2021,
Номер
23(1), С. 225 - 248
Опубликована: Март 31, 2021
Red
blood
cell
(RBC)
hitchhiking
is
a
method
of
drug
delivery
that
can
increase
concentration
in
target
organs
by
orders
magnitude.
In
RBC
hitchhiking,
drug-loaded
nanoparticles
(NPs)
are
adsorbed
onto
red
cells
and
then
injected
intravascularly,
which
causes
the
NPs
to
transfer
capillaries
downstream
organ.
has
been
demonstrated
multiple
species
organs.
For
example,
RBC-hitchhiking
localized
at
unprecedented
levels
brain
when
using
intra-arterial
catheters,
such
as
those
place
immediately
after
mechanical
thrombectomy
for
acute
ischemic
stroke.
successfully
employed
numerous
preclinical
models
disease,
ranging
from
pulmonary
embolism
cancer
metastasis.
addition
summarizing
versatility
we
also
describe
studies
into
surprisingly
complex
mechanisms
well
outline
future
further
improve
hitchhiking's
clinical
utility.
Chemical Reviews,
Год журнала:
2021,
Номер
121(18), С. 11385 - 11457
Опубликована: Май 3, 2021
Advances
in
hydrogel
technology
have
unlocked
unique
and
valuable
capabilities
that
are
being
applied
to
a
diverse
set
of
translational
applications.
Hydrogels
perform
functions
relevant
range
biomedical
purposes-they
can
deliver
drugs
or
cells,
regenerate
hard
soft
tissues,
adhere
wet
prevent
bleeding,
provide
contrast
during
imaging,
protect
tissues
organs
radiotherapy,
improve
the
biocompatibility
medical
implants.
These
make
hydrogels
useful
for
many
distinct
pressing
diseases
conditions
even
less
conventional
areas
such
as
environmental
engineering.
In
this
review,
we
cover
major
hydrogels,
with
focus
on
novel
benefits
injectable
how
they
relate
applications
medicine
environment.
We
pay
close
attention
development
contemporary
requires
extensive
interdisciplinary
collaboration
accomplish
highly
specific
complex
biological
tasks
from
cancer
immunotherapy
tissue
engineering
vaccination.
complement
our
discussion
preclinical
clinical
mechanical
design
considerations
needed
scaling
technologies
application.
anticipate
readers
will
gain
more
complete
picture
expansive
possibilities
practical
impactful
differences
across
numerous
fields
Chemical Reviews,
Год журнала:
2022,
Номер
122(6), С. 5977 - 6039
Опубликована: Фев. 2, 2022
The
stimulator
of
interferon
genes
(STING)
cellular
signaling
pathway
is
a
promising
target
for
cancer
immunotherapy.
Activation
the
intracellular
STING
protein
triggers
production
multifaceted
array
immunostimulatory
molecules,
which,
in
proper
context,
can
drive
dendritic
cell
maturation,
antitumor
macrophage
polarization,
T
priming
and
activation,
natural
killer
vascular
reprogramming,
and/or
death,
resulting
immune-mediated
tumor
elimination
generation
immune
memory.
Accordingly,
there
significant
amount
ongoing
preclinical
clinical
research
toward
further
understanding
role
surveillance
as
well
development
modulators
strategy
to
stimulate
immunity.
Yet,
efficacy
agonists
limited
by
many
drug
delivery
pharmacological
challenges.
Depending
on
class
agonist
desired
administration
route,
these
may
include
poor
stability,
immunocellular
toxicity,
immune-related
adverse
events,
or
lymph
node
targeting
retention,
low
uptake
delivery,
complex
dependence
magnitude
kinetics
signaling.
This
review
provides
concise
summary
pathway,
highlighting
recent
biological
developments,
immunological
consequences,
implications
delivery.
also
offers
critical
analysis
an
expanding
arsenal
chemical
strategies
that
are
being
employed
enhance
efficacy,
safety,
utility
lastly
draws
attention
several
opportunities
therapeutic
advancements.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2700 - 2700
Опубликована: Янв. 31, 2023
mRNA
vaccines
have
been
demonstrated
as
a
powerful
alternative
to
traditional
conventional
because
of
their
high
potency,
safety
and
efficacy,
capacity
for
rapid
clinical
development,
potential
rapid,
low-cost
manufacturing.
These
progressed
from
being
mere
curiosity
emerging
COVID-19
pandemic
vaccine
front-runners.
The
advancements
in
the
field
nanotechnology
developing
delivery
vehicles
are
highly
significant.
In
this
review
we
summarized
each
every
aspect
vaccine.
article
describes
structure,
its
pharmacological
function
immunity
induction,
lipid
nanoparticles
(LNPs),
upstream,
downstream,
formulation
process
Additionally,
trials
also
described.
A
deep
dive
into
future
perspectives
vaccines,
such
freeze-drying,
systems,
LNPs
targeting
antigen-presenting
cells
dendritic
cells,
summarized.
