Plants,
Год журнала:
2021,
Номер
10(6), С. 1238 - 1238
Опубликована: Июнь 18, 2021
Plants
constitute
a
rich
source
of
diverse
classes
valuable
phytochemicals
(e.g.,
phenolic
acids,
flavonoids,
carotenoids,
alkaloids)
with
proven
biological
activity
antioxidant,
anti-inflammatory,
antimicrobial,
etc.).
However,
factors
such
as
low
stability,
poor
solubility
and
bioavailability
limit
their
food,
cosmetics
pharmaceutical
applications.
In
this
regard,
wide
range
delivery
systems
have
been
developed
to
increase
the
stability
plant-derived
bioactive
compounds
upon
processing,
storage
or
under
gastrointestinal
digestion
conditions,
enhance
solubility,
mask
undesirable
flavors
well
efficiently
deliver
them
target
tissues
where
they
can
exert
promote
human
health.
present
review,
latest
advances
regarding
design
innovative
for
pure
plant
compounds,
extracts
essential
oils,
in
order
overcome
above-mentioned
challenges,
are
presented.
Moreover,
broad
spectrum
applications
along
future
trends
critically
discussed.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(12), С. 6385 - 6385
Опубликована: Июнь 15, 2021
Glioblastoma
multiforme
(GBM)
is
the
most
common
and
fatal
primary
brain
tumor,
highly
resistant
to
conventional
radiation
chemotherapy,
not
amenable
effective
surgical
resection.
The
present
review
summarizes
recent
advances
in
our
understanding
of
molecular
mechanisms
therapeutic
resistance
GBM
already
known
drugs,
characteristics
glioblastoma
cells,
barriers
that
underlie
drug
resistance.
We
also
discuss
progress
has
been
made
development
new
targeted
drugs
for
glioblastoma,
as
well
delivery
across
blood–brain
barrier
(BBB)
tumor
(BBTB).
Journal of Clinical and Translational Research,
Год журнала:
2021,
Номер
unknown
Опубликована: Янв. 1, 2021
Background:
Worldwide,
lung
cancer
is
one
of
the
leading
causes
death.Nevertheless,
new
therapeutic
agents
have
been
developed
to
treat
that
could
change
this
mortality-rate.Interestingly,
incredible
advances
occurred
in
recent
years
development
and
application
nanotechnology
detection,
diagnosis,
treatment
cancer.Aim:
Nanoparticles
(NPs)
ability
incorporate
multiple
drugs
targeting
therefore
lead
an
improved
bioavailability,
sustained
delivery,
solubility,
intestinal
absorption.Relevance
for
patients:
This
review
briefly
summarizes
latest
innovations
nanomedicine
with
examples
on
magnetic,
lipid,
polymer
NP.Emphasis
will
be
placed
future
studies
ongoing
clinical
trials
field.
Vaccines,
Год журнала:
2022,
Номер
10(2), С. 227 - 227
Опубликована: Фев. 2, 2022
Virus-like
particles
(VLPs)
are
self-assembled
viral
protein
complexes
that
mimic
the
native
virus
structure
without
being
infectious.
VLPs,
similarly
to
wild
type
viruses,
able
efficiently
target
and
activate
dendritic
cells
(DCs)
triggering
B
T
cell
immunities.
Therefore,
VLPs
hold
great
promise
for
development
of
effective
affordable
vaccines
in
infectious
diseases
cancers.
Vaccine
formulations
based
on
compared
other
nanoparticles,
have
advantage
incorporating
multiple
antigens
derived
from
different
proteins.
Moreover,
such
can
be
functionalized
by
chemical
modifications
affecting
structural
conformation
or
antigenicity.
This
review
summarizes
current
status
preventive
therapeutic
VLP-based
developed
against
human
oncoviruses
as
well
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(15), С. 8579 - 8579
Опубликована: Авг. 2, 2022
Nanotechnology
is
a
fast-evolving
field
focused
on
fabricating
nanoscale
objects
for
industrial,
cosmetic,
and
therapeutic
applications.
Virus-like
particles
(VLPs)
are
self-assembled
nanoparticles
whose
intrinsic
properties,
such
as
heterogeneity,
highly
ordered
structural
organization
exploited
to
prepare
vaccines;
imaging
agents;
construct
nanobioreactors;
cancer
treatment
approaches;
or
deliver
drugs,
genes,
enzymes.
However,
depending
upon
the
features
of
native
virus
from
which
they
produced,
performance
VLPs
can
vary.
This
review
compiles
recent
scientific
literature
about
fundamentals
with
biomedical
We
consulted
different
databases
present
general
scenario
viruses
how
produced
in
eukaryotic
prokaryotic
cell
lines
entrap
cargo.
Moreover,
classification,
morphology,
methods
functionalize
surface
discussed.
Finally,
characterization
techniques
required
examine
size,
charge,
aggregation,
composition
described.
Plants,
Год журнала:
2021,
Номер
10(6), С. 1238 - 1238
Опубликована: Июнь 18, 2021
Plants
constitute
a
rich
source
of
diverse
classes
valuable
phytochemicals
(e.g.,
phenolic
acids,
flavonoids,
carotenoids,
alkaloids)
with
proven
biological
activity
antioxidant,
anti-inflammatory,
antimicrobial,
etc.).
However,
factors
such
as
low
stability,
poor
solubility
and
bioavailability
limit
their
food,
cosmetics
pharmaceutical
applications.
In
this
regard,
wide
range
delivery
systems
have
been
developed
to
increase
the
stability
plant-derived
bioactive
compounds
upon
processing,
storage
or
under
gastrointestinal
digestion
conditions,
enhance
solubility,
mask
undesirable
flavors
well
efficiently
deliver
them
target
tissues
where
they
can
exert
promote
human
health.
present
review,
latest
advances
regarding
design
innovative
for
pure
plant
compounds,
extracts
essential
oils,
in
order
overcome
above-mentioned
challenges,
are
presented.
Moreover,
broad
spectrum
applications
along
future
trends
critically
discussed.
