Integrating synthetic polypeptides with innovative material forming techniques for advanced biomedical applications DOI Creative Commons

Dandan Kang,

Yu Zhang,

Deng‐Guang Yu

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 12, 2025

Polypeptides are highly valued in biomedical science for their biocompatibility and biodegradability, making them valuable drug delivery, tissue engineering, antibacterial dressing. The diverse design of polymer chains self-assembly techniques allow different side secondary structures, enhancing potential. However, the traditional solid powder form polypeptides presents challenges skin applications, shipping, recycling, limiting practical utility. Recent advancements material forming methods polypeptide synthesis have produced biomaterials with uniform, distinct shapes, improving usability. This review outlines progress material-forming over past decade. main include solid-phase ring-opening polymerization N-carboxyanhydrides while like electrospinning, 3D printing, coating explored. Integrating structural these is emphasized, leading to materials unique shapes. also identifies research hotspots using VOSviewer software, which visually presented circular packing images. It further discusses emerging applications such as wound healing, emphasizing crucial role shape performance. concludes by exploring future trends developing shapes advanced encouraging research.

Язык: Английский

Additive manufacturing technologies with emphasis on stereolithography 3D printing in pharmaceutical and medical applications: A review DOI Creative Commons
Preethi Lakkala, Siva Ram Munnangi,

Suresh Bandari

и другие.

International Journal of Pharmaceutics X, Год журнала: 2023, Номер 5, С. 100159 - 100159

Опубликована: Янв. 3, 2023

Three-dimensional (3D) printing or Additive Manufacturing (AM) technology is an innovative tool with great potential and diverse applications in various fields. As 3D has been burgeoning recent times, a tremendous transformation can be envisaged medical care, especially the manufacturing procedures leading to personalized medicine. Stereolithography (SLA), vat-photopolymerization technique, that uses laser beam, known for its ability fabricate complex structures ranging from micron-size needles life-size organs, because of high resolution, precision, accuracy, speed. This review presents glimpse varied techniques, mainly expounding SLA terms materials used, orientation printing, working mechanisms. The previous works focused on developing pharmaceutical dosage forms, drug-eluting devices, tissue scaffolds are presented this paper, followed by challenges associated industrial regulatory perspective. Due excellent advantages, could transform conventional "one dose fits all" concept bring digitalized patient-centric medication into reality.

Язык: Английский

Процитировано

156
Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers DOI Creative Commons
Ali Tariq, Zia Ullah Arif, Muhammad Yasir Khalid

и другие.

Advanced Engineering Materials, Год журнала: 2023, Номер 25(21)

Опубликована: Авг. 29, 2023

Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, robots, wearable devices, sensors, self‐expanding structures, and biomedical thanks to their ability change shapes functional properties in response external stimuli including light, humidity, heat, pH, electric field, solvent, magnetic field or combinations two more these stimuli. In recent years, additive manufacturing (AM) aka 3D printing technology SRPs, also known as 4D printing, has gained phenomenal attention different engineering fields, its unique develop complex, personalized, innovative undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, other complex morphological transformations. Herein, an effort made provide insightful information about the AM techniques, type applications including, but not limited tissue engineering, bionics, construction, smart textiles. This article incorporates current challenges prospects, hoping basis utilization this fields. It is expected that amalgamation with SRPs would unparalleled advantages arenas.

Язык: Английский

Процитировано

87
Recent Advances in the Applications of Additive Manufacturing (3D Printing) in Drug Delivery: A Comprehensive Review DOI
Derick Muhindo, Rasha M. Elkanayati, Priyanka Srinivasan

и другие.

AAPS PharmSciTech, Год журнала: 2023, Номер 24(2)

Опубликована: Фев. 9, 2023

Язык: Английский

Процитировано

66
3D‐Printed Micro/Nano‐Scaled Mechanical Metamaterials: Fundamentals, Technologies, Progress, Applications, and Challenges DOI

Ruyue Su,

Jingyi Chen,

Xueqin Zhang

и другие.

Small, Год журнала: 2023, Номер 19(29)

Опубликована: Апрель 7, 2023

Micro/nano-scaled mechanical metamaterials have attracted extensive attention in various fields attributed to their superior properties benefiting from rationally designed micro/nano-structures. As one of the most advanced technologies 21st century, additive manufacturing (3D printing) opens an easier and faster path for fabricating micro/nano-scaled with complex structures. Here, size effect at micro/nano scales is introduced first. Then, fabricate are introduced. The latest research progress on also reviewed according type materials. In addition, structural functional applications further summarized. Finally, challenges, including 3D printing technologies, novel material development, innovative design, discussed, future perspectives provided. review aims provide insight into development 3D-printed metamaterials.

Язык: Английский

Процитировано

62
3D bio-printing for use as bone replacement tissues: A review of biomedical application DOI Creative Commons
Ashkan Farazin, Chunwei Zhang,

Amirhossein Gheisizadeh

и другие.

Biomedical Engineering Advances, Год журнала: 2023, Номер 5, С. 100075 - 100075

Опубликована: Янв. 31, 2023

Since we are able to use 3D printers, producing porous metal scaffolds become very easy. Contrary usual methods, printing of is determined by a controllable and precise manufacturing process. That property allows us form customized prefabricated implants for individual patients make regular pore distribution at the micro-scale as same structure bone, design like bone complicated because pores that must have enough space cell attachment proliferation. The reaction cells ingrowth can influence effect printed on ingrowth. This review introduces techniques brief focuses factors potentially into materials, size, porosity, structure, surface modification, mechanical properties. In each section, described mechanisms underlying cell-scaffold interactions in detail also there short introduction clinical application printing. After all, list shows most appropriate parameters flawless scaffold, it lead finding combination these foretaste good

Язык: Английский

Процитировано

57
Empowering Precision Medicine: The Impact of 3D Printing on Personalized Therapeutic DOI Creative Commons
Lorca Alzoubi, Alaa A. A. Aljabali, Murtaza M. Tambuwala

и другие.

AAPS PharmSciTech, Год журнала: 2023, Номер 24(8)

Опубликована: Ноя. 14, 2023

Abstract This review explores recent advancements and applications of 3D printing in healthcare, with a focus on personalized medicine, tissue engineering, medical device production. It also assesses economic, environmental, ethical considerations. In our the literature, we employed comprehensive search strategy, utilizing well-known databases like PubMed Google Scholar. Our chosen keywords encompassed essential topics, including printing, nanotechnology, related areas. We first screened article titles abstracts then conducted detailed examination selected articles without imposing any date limitations. The for inclusion, comprising research studies, clinical investigations, expert opinions, underwent meticulous quality assessment. methodology ensured incorporation high-quality sources, contributing to robust exploration role realm healthcare. highlights printing's potential customized drug delivery systems, patient-specific implants, prosthetics, biofabrication organs. These innovations have significantly improved patient outcomes. Integration nanotechnology has enhanced precision biocompatibility. demonstrates cost-effectiveness sustainability through optimized material usage recycling. healthcare sector witnessed remarkable progress promoting patient-centric approach. From implants radiation shielding offers tailored solutions. Its transformative applications, coupled economic viability sustainability, revolutionize Addressing biocompatibility, standardization, concerns is responsible adoption. Graphical

Язык: Английский

Процитировано

55
Advances in Hydrogel-Based Drug Delivery Systems DOI Creative Commons
Boya Liu, Kuo Chen

Gels, Год журнала: 2024, Номер 10(4), С. 262 - 262

Опубликована: Апрель 13, 2024

Hydrogels, with their distinctive three-dimensional networks of hydrophilic polymers, drive innovations across various biomedical applications. The ability hydrogels to absorb and retain significant volumes water, coupled structural integrity responsiveness environmental stimuli, renders them ideal for drug delivery, tissue engineering, wound healing. This review delves into the classification based on cross-linking methods, providing insights synthesis, properties, We further discuss recent advancements in hydrogel-based delivery systems, including oral, injectable, topical, ocular approaches, highlighting significance enhancing therapeutic outcomes. Additionally, we address challenges faced clinical translation propose future directions leveraging potential personalized medicine regenerative healthcare solutions.

Язык: Английский

Процитировано

50
Roll-to-roll, high-resolution 3D printing of shape-specific particles DOI Creative Commons
Jason M. Kronenfeld, Lukas Rother, Max A. Saccone

и другие.

Nature, Год журнала: 2024, Номер 627(8003), С. 306 - 312

Опубликована: Март 13, 2024

Abstract Particle fabrication has attracted recent attention owing to its diverse applications in bioengineering 1,2 , drug and vaccine delivery 3–5 microfluidics 6,7 granular systems 8,9 self-assembly 5,10,11 microelectronics 12,13 abrasives 14 . Herein we introduce a scalable, high-resolution, 3D printing technique for the of shape-specific particles based on roll-to-roll continuous liquid interface production (r2rCLIP). We demonstrate r2rCLIP using single-digit, micron-resolution optics combination with roll film (in lieu static platform), enabling rapidly permutable harvesting from variety materials complex geometries, including geometries not possible achieve advanced mould-based techniques. mouldable non-mouldable shapes voxel sizes as small 2.0 × µm 2 print plane 1.1 ± 0.3 unsupported thickness, at speeds up 1,000,000 per day. Such microscopic permutable, intricate designs enable direct integration within biomedical, analytical applications.

Язык: Английский

Процитировано

39
Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation—Where Are We Now? DOI Creative Commons

Hemlata Patil,

Sateesh Kumar Vemula, Sagar Narala

и другие.

AAPS PharmSciTech, Год журнала: 2024, Номер 25(2)

Опубликована: Фев. 14, 2024

Abstract Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers an efficient continuous manufacturing process. The twin-screw extruder (TSE) extremely resourceful customizable mixer used for compounding granulation by using different combinations conveying elements, kneading elements (forward reverse configuration), distributive mixing elements. TSE thus efficiently utilized dry, wet, or melt not only to manufacture dosage forms such as tablets, capsules, granule-filled sachets, but also designing novel formulations dry powder inhalers, drying units granules, nanoextrusion, 3D printing, complexation, amorphous solid dispersions. Over past decades, combined academic industry collaborations have driven innovations HME technology, which has resulted in substantial increase published articles patents. This article summarizes challenges models executing scale-up. Additionally, it covers benefits manufacturing, process analytical (PAT) considerations, regulatory requirements. In summary, this well-designed review builds upon our earlier publication, probing deeper into potential extruders various new applications. Graphical

Язык: Английский

Процитировано

33
3D printing processes in precise drug delivery for personalized medicine DOI Creative Commons
Haisheng Peng, Bo Han, Tianjian Tong

и другие.

Biofabrication, Год журнала: 2024, Номер 16(3), С. 032001 - 032001

Опубликована: Апрель 3, 2024

Abstract With the advent of personalized medicine, drug delivery system will be changed significantly. The development medicine needs support many technologies, among which three-dimensional printing (3DP) technology is a novel formulation-preparing process that creates 3D objects by depositing materials layer-by-layer based on computer-aided design method. Compared with traditional pharmaceutical processes, 3DP produces complex combinations, dosage, and flexible shape structure dosage forms (DFs) demand. In future, drugs may supplement even replace their counterpart. We systematically introduce applications technologies in industry summarize virtues shortcomings each technique. release behaviors control mechanisms DFs desired structures are also analyzed. Finally, benefits, challenges, prospects to discussed.

Язык: Английский

Процитировано

26