Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 12, 2025
Polypeptides
are
highly
valued
in
biomedical
science
for
their
biocompatibility
and
biodegradability,
making
them
valuable
drug
delivery,
tissue
engineering,
antibacterial
dressing.
The
diverse
design
of
polymer
chains
self-assembly
techniques
allow
different
side
secondary
structures,
enhancing
potential.
However,
the
traditional
solid
powder
form
polypeptides
presents
challenges
skin
applications,
shipping,
recycling,
limiting
practical
utility.
Recent
advancements
material
forming
methods
polypeptide
synthesis
have
produced
biomaterials
with
uniform,
distinct
shapes,
improving
usability.
This
review
outlines
progress
material-forming
over
past
decade.
main
include
solid-phase
ring-opening
polymerization
N-carboxyanhydrides
while
like
electrospinning,
3D
printing,
coating
explored.
Integrating
structural
these
is
emphasized,
leading
to
materials
unique
shapes.
also
identifies
research
hotspots
using
VOSviewer
software,
which
visually
presented
circular
packing
images.
It
further
discusses
emerging
applications
such
as
wound
healing,
emphasizing
crucial
role
shape
performance.
concludes
by
exploring
future
trends
developing
shapes
advanced
encouraging
research.
International Journal of Pharmaceutics X,
Год журнала:
2023,
Номер
5, С. 100159 - 100159
Опубликована: Янв. 3, 2023
Three-dimensional
(3D)
printing
or
Additive
Manufacturing
(AM)
technology
is
an
innovative
tool
with
great
potential
and
diverse
applications
in
various
fields.
As
3D
has
been
burgeoning
recent
times,
a
tremendous
transformation
can
be
envisaged
medical
care,
especially
the
manufacturing
procedures
leading
to
personalized
medicine.
Stereolithography
(SLA),
vat-photopolymerization
technique,
that
uses
laser
beam,
known
for
its
ability
fabricate
complex
structures
ranging
from
micron-size
needles
life-size
organs,
because
of
high
resolution,
precision,
accuracy,
speed.
This
review
presents
glimpse
varied
techniques,
mainly
expounding
SLA
terms
materials
used,
orientation
printing,
working
mechanisms.
The
previous
works
focused
on
developing
pharmaceutical
dosage
forms,
drug-eluting
devices,
tissue
scaffolds
are
presented
this
paper,
followed
by
challenges
associated
industrial
regulatory
perspective.
Due
excellent
advantages,
could
transform
conventional
"one
dose
fits
all"
concept
bring
digitalized
patient-centric
medication
into
reality.
Advanced Engineering Materials,
Год журнала:
2023,
Номер
25(21)
Опубликована: Авг. 29, 2023
Stimuli‐responsive
polymers
(SRPs)
are
special
types
of
soft
materials,
which
have
been
extensively
used
for
developing
flexible
actuators,
robots,
wearable
devices,
sensors,
self‐expanding
structures,
and
biomedical
thanks
to
their
ability
change
shapes
functional
properties
in
response
external
stimuli
including
light,
humidity,
heat,
pH,
electric
field,
solvent,
magnetic
field
or
combinations
two
more
these
stimuli.
In
recent
years,
additive
manufacturing
(AM)
aka
3D
printing
technology
SRPs,
also
known
as
4D
printing,
has
gained
phenomenal
attention
different
engineering
fields,
its
unique
develop
complex,
personalized,
innovative
undergo
twisting,
elongating,
swelling,
rolling,
shrinking,
bending,
spiraling,
other
complex
morphological
transformations.
Herein,
an
effort
made
provide
insightful
information
about
the
AM
techniques,
type
applications
including,
but
not
limited
tissue
engineering,
bionics,
construction,
smart
textiles.
This
article
incorporates
current
challenges
prospects,
hoping
basis
utilization
this
fields.
It
is
expected
that
amalgamation
with
SRPs
would
unparalleled
advantages
arenas.
Micro/nano-scaled
mechanical
metamaterials
have
attracted
extensive
attention
in
various
fields
attributed
to
their
superior
properties
benefiting
from
rationally
designed
micro/nano-structures.
As
one
of
the
most
advanced
technologies
21st
century,
additive
manufacturing
(3D
printing)
opens
an
easier
and
faster
path
for
fabricating
micro/nano-scaled
with
complex
structures.
Here,
size
effect
at
micro/nano
scales
is
introduced
first.
Then,
fabricate
are
introduced.
The
latest
research
progress
on
also
reviewed
according
type
materials.
In
addition,
structural
functional
applications
further
summarized.
Finally,
challenges,
including
3D
printing
technologies,
novel
material
development,
innovative
design,
discussed,
future
perspectives
provided.
review
aims
provide
insight
into
development
3D-printed
metamaterials.
Biomedical Engineering Advances,
Год журнала:
2023,
Номер
5, С. 100075 - 100075
Опубликована: Янв. 31, 2023
Since
we
are
able
to
use
3D
printers,
producing
porous
metal
scaffolds
become
very
easy.
Contrary
usual
methods,
printing
of
is
determined
by
a
controllable
and
precise
manufacturing
process.
That
property
allows
us
form
customized
prefabricated
implants
for
individual
patients
make
regular
pore
distribution
at
the
micro-scale
as
same
structure
bone,
design
like
bone
complicated
because
pores
that
must
have
enough
space
cell
attachment
proliferation.
The
reaction
cells
ingrowth
can
influence
effect
printed
on
ingrowth.
This
review
introduces
techniques
brief
focuses
factors
potentially
into
materials,
size,
porosity,
structure,
surface
modification,
mechanical
properties.
In
each
section,
described
mechanisms
underlying
cell-scaffold
interactions
in
detail
also
there
short
introduction
clinical
application
printing.
After
all,
list
shows
most
appropriate
parameters
flawless
scaffold,
it
lead
finding
combination
these
foretaste
good
Abstract
This
review
explores
recent
advancements
and
applications
of
3D
printing
in
healthcare,
with
a
focus
on
personalized
medicine,
tissue
engineering,
medical
device
production.
It
also
assesses
economic,
environmental,
ethical
considerations.
In
our
the
literature,
we
employed
comprehensive
search
strategy,
utilizing
well-known
databases
like
PubMed
Google
Scholar.
Our
chosen
keywords
encompassed
essential
topics,
including
printing,
nanotechnology,
related
areas.
We
first
screened
article
titles
abstracts
then
conducted
detailed
examination
selected
articles
without
imposing
any
date
limitations.
The
for
inclusion,
comprising
research
studies,
clinical
investigations,
expert
opinions,
underwent
meticulous
quality
assessment.
methodology
ensured
incorporation
high-quality
sources,
contributing
to
robust
exploration
role
realm
healthcare.
highlights
printing's
potential
customized
drug
delivery
systems,
patient-specific
implants,
prosthetics,
biofabrication
organs.
These
innovations
have
significantly
improved
patient
outcomes.
Integration
nanotechnology
has
enhanced
precision
biocompatibility.
demonstrates
cost-effectiveness
sustainability
through
optimized
material
usage
recycling.
healthcare
sector
witnessed
remarkable
progress
promoting
patient-centric
approach.
From
implants
radiation
shielding
offers
tailored
solutions.
Its
transformative
applications,
coupled
economic
viability
sustainability,
revolutionize
Addressing
biocompatibility,
standardization,
concerns
is
responsible
adoption.
Graphical
Gels,
Год журнала:
2024,
Номер
10(4), С. 262 - 262
Опубликована: Апрель 13, 2024
Hydrogels,
with
their
distinctive
three-dimensional
networks
of
hydrophilic
polymers,
drive
innovations
across
various
biomedical
applications.
The
ability
hydrogels
to
absorb
and
retain
significant
volumes
water,
coupled
structural
integrity
responsiveness
environmental
stimuli,
renders
them
ideal
for
drug
delivery,
tissue
engineering,
wound
healing.
This
review
delves
into
the
classification
based
on
cross-linking
methods,
providing
insights
synthesis,
properties,
We
further
discuss
recent
advancements
in
hydrogel-based
delivery
systems,
including
oral,
injectable,
topical,
ocular
approaches,
highlighting
significance
enhancing
therapeutic
outcomes.
Additionally,
we
address
challenges
faced
clinical
translation
propose
future
directions
leveraging
potential
personalized
medicine
regenerative
healthcare
solutions.
Nature,
Год журнала:
2024,
Номер
627(8003), С. 306 - 312
Опубликована: Март 13, 2024
Abstract
Particle
fabrication
has
attracted
recent
attention
owing
to
its
diverse
applications
in
bioengineering
1,2
,
drug
and
vaccine
delivery
3–5
microfluidics
6,7
granular
systems
8,9
self-assembly
5,10,11
microelectronics
12,13
abrasives
14
.
Herein
we
introduce
a
scalable,
high-resolution,
3D
printing
technique
for
the
of
shape-specific
particles
based
on
roll-to-roll
continuous
liquid
interface
production
(r2rCLIP).
We
demonstrate
r2rCLIP
using
single-digit,
micron-resolution
optics
combination
with
roll
film
(in
lieu
static
platform),
enabling
rapidly
permutable
harvesting
from
variety
materials
complex
geometries,
including
geometries
not
possible
achieve
advanced
mould-based
techniques.
mouldable
non-mouldable
shapes
voxel
sizes
as
small
2.0
×
µm
2
print
plane
1.1
±
0.3
unsupported
thickness,
at
speeds
up
1,000,000
per
day.
Such
microscopic
permutable,
intricate
designs
enable
direct
integration
within
biomedical,
analytical
applications.
Abstract
Hot-melt
extrusion
(HME)
is
a
globally
recognized,
robust,
effective
technology
that
enhances
the
bioavailability
of
poorly
soluble
active
pharmaceutical
ingredients
and
offers
an
efficient
continuous
manufacturing
process.
The
twin-screw
extruder
(TSE)
extremely
resourceful
customizable
mixer
used
for
compounding
granulation
by
using
different
combinations
conveying
elements,
kneading
elements
(forward
reverse
configuration),
distributive
mixing
elements.
TSE
thus
efficiently
utilized
dry,
wet,
or
melt
not
only
to
manufacture
dosage
forms
such
as
tablets,
capsules,
granule-filled
sachets,
but
also
designing
novel
formulations
dry
powder
inhalers,
drying
units
granules,
nanoextrusion,
3D
printing,
complexation,
amorphous
solid
dispersions.
Over
past
decades,
combined
academic
industry
collaborations
have
driven
innovations
HME
technology,
which
has
resulted
in
substantial
increase
published
articles
patents.
This
article
summarizes
challenges
models
executing
scale-up.
Additionally,
it
covers
benefits
manufacturing,
process
analytical
(PAT)
considerations,
regulatory
requirements.
In
summary,
this
well-designed
review
builds
upon
our
earlier
publication,
probing
deeper
into
potential
extruders
various
new
applications.
Graphical
Biofabrication,
Год журнала:
2024,
Номер
16(3), С. 032001 - 032001
Опубликована: Апрель 3, 2024
Abstract
With
the
advent
of
personalized
medicine,
drug
delivery
system
will
be
changed
significantly.
The
development
medicine
needs
support
many
technologies,
among
which
three-dimensional
printing
(3DP)
technology
is
a
novel
formulation-preparing
process
that
creates
3D
objects
by
depositing
materials
layer-by-layer
based
on
computer-aided
design
method.
Compared
with
traditional
pharmaceutical
processes,
3DP
produces
complex
combinations,
dosage,
and
flexible
shape
structure
dosage
forms
(DFs)
demand.
In
future,
drugs
may
supplement
even
replace
their
counterpart.
We
systematically
introduce
applications
technologies
in
industry
summarize
virtues
shortcomings
each
technique.
release
behaviors
control
mechanisms
DFs
desired
structures
are
also
analyzed.
Finally,
benefits,
challenges,
prospects
to
discussed.