Bioprinting, Год журнала: 2025, Номер 45, С. e00386 - e00386
Опубликована: Янв. 5, 2025
Язык: Английский
Polymers, Год журнала: 2022, Номер 14(21), С. 4698 - 4698
Опубликована: Ноя. 3, 2022
The scientific community is and has constantly been working to innovate improve the available technologies in our use. In that effort, three-dimensional (3D) printing was developed can construct 3D objects from a digital file. Three-dimensional printing, also known as additive manufacturing (AM), seen tremendous growth over last three decades, five years, its application widened significantly. technology potential fill gaps left by limitations of current technologies, it further become exciting with addition time dimension giving rise concept four-dimensional (4D) which essentially means structures created 4D undergo transformation under influence internal or external stimuli. are able adapt changing environmental variables such moisture, temperature, light, pH value, etc. Since their introduction, have extensively used healthcare, aerospace, construction, fashion industries. Although highly promising future, there still number challenges must be solved before advance. this paper, we reviewed recent advances materials for use, future applications. role imperative fight against COVID-19 discussed. Moreover, major developments overcoming those addressed. This document provides cutting-edge review materials, applications, technologies.
Язык: Английский
Процитировано
67
Journal of Controlled Release, Год журнала: 2022, Номер 350, С. 933 - 948
Опубликована: Сен. 26, 2022
Язык: Английский
Процитировано
65
Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 177, С. 113923 - 113923
Опубликована: Авг. 11, 2021
Materials and manufacturing processes share a common purpose of enabling the pharmaceutical product to perform as intended. This review on role polymeric materials in additive oral dosage forms, focuses interface between polymer key stages process, which determine printability. By systematically clarifying comparing functional roles properties for variety AM technologies, together with current emerging techniques characterize these properties, suggestions are provided stimulate use readily available sometimes underutilized polymers manufacturing. We point characterization digital tools, can be harnessed manage existing trade-offs printer compatibility versus performance. In rapidly evolving technological space, this serves trigger continued development 3D printers suit broader widespread applications
Язык: Английский
Процитировано
61
Biomedical Materials, Год журнала: 2022, Номер 17(6), С. 062001 - 062001
Опубликована: Авг. 31, 2022
Abstract Nature’s materials have evolved over time to be able respond environmental stimuli by generating complex structures that can change their functions in response distance, time, and direction of stimuli. A number technical efforts are currently being made improve printing resolution, shape fidelity, speed mimic the structural design natural with three-dimensional printing. Unfortunately, this technology is limited fact printed objects static cannot reshaped dynamically In recent years, several smart been developed undergo dynamic morphing a stimulus, thus resolving issue. Four-dimensional (4D) refers manufacturing process involving additive manufacturing, materials, specific geometries. It has become an essential for biomedical engineering potential create wide range useful products. This paper will discuss concept 4D bioprinting developments which actuated different exploited develop biomimetic structures, significant implications pharmaceutics research, as well prospects future.
Язык: Английский
Процитировано
59
International Journal of Pharmaceutics, Год журнала: 2022, Номер 616, С. 121553 - 121553
Опубликована: Фев. 5, 2022
Язык: Английский
Процитировано
41
Talanta, Год журнала: 2023, Номер 266, С. 124996 - 124996
Опубликована: Июль 27, 2023
Язык: Английский
Процитировано
41
Pharmaceutics, Год журнала: 2023, Номер 15(7), С. 1877 - 1877
Опубликована: Июль 4, 2023
Three-dimensional (3D) printing is an unrivaled technique that uses computer-aided design and programming to create 3D products by stacking materials on a substrate. Today, technology used in the whole drug development process, from preclinical research clinical trials frontline medical treatment. From 2009 2020, number of articles healthcare applications surged around 10 2000. has been applied several kinds delivery systems, such as oral controlled release micropills, microchips, implants, microneedles, rapid dissolving tablets, multiphase dosage forms. Compared with conventional manufacturing methods pharmaceutical products, many advantages, including high production rates due flexible operating systems loading desired precision accuracy for potent drugs administered small doses. The cost via can be decreased reducing material wastage, process adapted multiple classes pharmaceutically active ingredients, those poor solubility. Although studies have addressed benefits technology, hospitals pharmacies only implemented this practical applications. This article discusses recent medicinal preparation. also covers potential future pharmaceuticals.
Язык: Английский
Процитировано
39
International Journal of Pharmaceutics X, Год журнала: 2023, Номер 5, С. 100171 - 100171
Опубликована: Фев. 20, 2023
Four-dimensional printing (4DP) is emerging as an innovative research topic. It involves the use of smart materials for three-dimensional (3DP) items that change their shape after production, in a programmed way over time, when exposed to appropriate external non-mechanical stimuli (moisture, electric or magnetic fields, UV, temperature, pH ion composition). In performance 4D printed devices, time involved 4th dimension. structures have been known many years scientific literature, well before advent 3D printing, and concepts evolution self-assembly applied drug delivery at nano-, micro- macro-scale levels. The neologism "4DP" was coined by Tibbits, Massachusetts Institute Technology, 2013, who also showed earliest examples objects. Since then, often combined with additive manufacturing, which makes production complex shapes easy achieve: going beyond 3DP, are no static Two main categories raw employed 4DP: memory polymers (SMPs) morphing hydrogels (SMHs). principle, all types printers could be used 4DP. this article, systems biomedical field, such stents scaffolds, reviewed, special emphasis on indwelling devices retention urinary bladder stomach.
Язык: Английский
Процитировано
35
Materials, Год журнала: 2023, Номер 16(16), С. 5610 - 5610
Опубликована: Авг. 13, 2023
Additive manufacturing (AM) is an attractive set of processes that are being employed lately to process specific materials used in the fabrication electrical machine components. This because AM allows for preservation or enhancement their magnetic properties, which may be degraded limited when manufactured using other traditional processes. Soft (SMMs), such as Fe–Si, Fe–Ni, Fe–Co, and soft composites (SMCs), suitable additive components due magnetic, thermal, mechanical, properties. In addition these, it has been observed literature alloys, ferrites, difficult low magnetization brittleness. However, thanks manufacturing, possible leverage high resistivity make them alternative candidates applications It important highlight significant progress field science, enabled development novel high-entropy alloys (HEAs). These complex chemical composition, can exhibit The aim present work provide a critical review state-of-the-art SMMs through different technologies. covers influence these technologies on microstructural changes, mechanical strengths, post-processing, parameters saturation (MS), coercivity (HC), remanence (Br), relative permeability (Mr), (r), thermal conductivity (k).
Язык: Английский
Процитировано
35
International Journal of Pharmaceutics X, Год журнала: 2023, Номер 5, С. 100166 - 100166
Опубликована: Фев. 8, 2023
3D printing is driving a shift in patient care away from generalised model and towards personalised treatments. To complement fast-paced clinical environments, technologies must provide sufficiently high throughputs for them to be feasibly implemented. Volumetric an emerging technology that affords such speeds, being capable of producing entire objects within seconds. In this study, the first time, rotatory volumetric was used simultaneously produce two torus- or cylinder-shaped paracetamol-loaded Printlets (3D printed tablets). Six resin formulations comprising paracetamol as drug, poly(ethylene glycol) diacrylate (PEGDA) 575 700 photoreactive monomers, water PEG 300 non-reactive diluents, lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) photoinitiator were investigated. Two printlets successfully 12 32 s exhibited sustained drug release profiles. These results support use rotary efficient effective manufacturing various medicines at same time. With speed precision it affords, has potential become one most promising alternative pharmaceutical industry.
Язык: Английский
Процитировано
27