Ferroptosis Nanomedicine: Clinical Challenges and Opportunities for Modulating Tumor Metabolic and Immunological Landscape

ACS Nano, Год журнала: 2023, Номер 17(16), С. 15328 - 15353

Опубликована: Авг. 13, 2023

Ferroptosis, a type of regulated cell death driven by iron-dependent phospholipid peroxidation, has captured much attention in the field nanomedicine since it was coined 2012. Compared with other modes such as apoptosis and pyroptosis, ferroptosis many distinct features molecular mechanisms cellular morphology, representing promising strategy for treating cancers that are resistant to conventional therapeutic modalities. Moreover, recent insights collectively reveal is tightly connected maintenance tumor immune microenvironment (TIME), suggesting potential application therapies evoking robust antitumor immunity. From biochemical perspective, intricately multiple metabolic pathways, including iron metabolism, lipid redox etc., highlighting importance elucidate relationship between metabolism developing therapies. In this review, we provide comprehensive discussion on current understanding ferroptosis-inducing thoroughly discuss various traits tumors, which offer opportunities direct inhibition through nanointegrated approach. Extending from complex impact TIME, also discussed those important considerations development ferroptosis-based immunotherapy, challenges strategies enhance ferroptosis-enabled immunostimulatory effects while avoiding side effects. We envision study may facilitate translation nanomedicines treatment.

Язык: Английский

---

Synergistic impact of nanomaterials and plant probiotics in agriculture: A tale of two-way strategy for long-term sustainability

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Май 3, 2023

Modern agriculture is primarily focused on the massive production of cereals and other food-based crops in a sustainable manner order to fulfill food demands an ever-increasing global population. However, intensive agricultural practices, rampant use agrochemicals, environmental factors result soil fertility degradation, pollution, disruption biodiversity, pest resistance, decline crop yields. Thus, experts are shifting their focus eco-friendly safer methods fertilization ensure sustainability. Indeed, importance plant growth-promoting microorganisms, also determined as “plant probiotics (PPs),” has gained widespread recognition, usage biofertilizers being actively promoted means mitigating harmful effects agrochemicals. As bio-elicitors, PPs promote growth colonize or tissues when administered soil, seeds, surface used alternative avoid heavy In past few years, nanotechnology brought revolution due application various nanomaterials (NMs) nano-based fertilizers increase productivity. Given beneficial properties NMs, these two can be tandem maximize benefits. combinations NMs PPs, synergistic use, its infancy but exhibited better crop-modulating terms improvement productivity, mitigation stress (drought, salinity, etc.), restoration fertility, strengthening bioeconomy. addition, proper assessment necessary before application, dose should applicable without showing any toxic impact environment microbial communities. The combo encapsulated within suitable carrier, this method aids controlled targeted delivery entrapped components increases shelf life PPs. review highlights functional annotation combined manner.

Язык: Английский

---

An Engineered Butyrate-Derived Polymer Nanoplatform as a Mucosa-Healing Enhancer Potentiates the Therapeutic Effect of Magnolol in Inflammatory Bowel Disease

ACS Nano, Год журнала: 2023, Номер 18(1), С. 229 - 244

Опубликована: Дек. 19, 2023

Colonic epithelial damage and dysregulated immune response are crucial factors in the progression exacerbation of inflammatory bowel disease (IBD). Nanoenabled targeted drug delivery to inflamed intestinal mucosa has shown promise inducing maintaining colitis remission, while minimizing side effects. Inspired by excellent antioxidative anti-inflammatory efficacy naturally derived magnolol (Mag) gut homeostasis regulation microbiota-derived butyrate, we developed a pH/redox dual-responsive butyrate-rich polymer nanoparticle (PSBA) as an oral Mag system for combinational therapy IBD. PSBA showed high butyrate content 22% effectively encapsulated Mag. The Mag-loaded nanoparticles (PSBA@Mag) demonstrated colonic pH reduction-responsive release, ensuring efficient retention adhesion colon mice. PSBA@Mag not only normalized level reactive oxygen species effectors but also restored barrier function both ulcerative Crohn's mouse models. Importantly, promoted migration healing ability cells vitro vivo, sensitizing therapeutic animal Moreover, transcriptomics metabolism analyses revealed that mitigated inflammation suppressing production pro-inflammatory cytokines chemokines restoring lipid metabolism. Additionally, this nanomedicine modulated microbiota inhibiting pathogenic Proteus Escherichia-Shigella promoting proliferation beneficial probiotics, including Lachnoclostridium, Lachnospiraceae_NK4A136_group norank_f_Ruminococcaceae. Overall, our findings highlight potential butyrate-functionalized polymethacrylates versatile effective nanoplatforms repair combating IBD other gastrointestinal disorders.

Язык: Английский

---

An Oral Nanomedicine Elicits In Situ Vaccination Effect against Colorectal Cancer

ACS Nano, Год журнала: 2024, Номер 18(4), С. 3651 - 3668

Опубликована: Янв. 19, 2024

Oral administration is the most preferred approach for treating colon diseases, and in situ vaccination has emerged as a promising cancer therapeutic strategy. However, lack of effective drug delivery platforms hampered application strategy oral treatment colorectal (CRC). Here, we construct an core–shell nanomedicine by preparing silk fibroin-based dual sonosensitizer (chlorin e6, Ce6)- immunoadjuvant (imiquimod, R837)-loaded nanoparticle core, with its surface coated plant-extracted lipids pluronic F127 (p127). The resultant nanomedicines (Ce6/R837@Lp127NPs) maintain stability during their passage through gastrointestinal tract exert improved locomotor activities under ultrasound irradiation, achieving efficient colonic mucus infiltration specific tumor penetration. Thereafter, Ce6/R837@Lp127NPs induce immunogenic death cells sonodynamic treatment, generated neoantigens presence R837 serve potent vaccine. By integrating immune checkpoint blockades, combined modality inhibits orthotopic tumors, eradicates distant modulates intestinal microbiota. As first vaccination, this work spotlights robust nanoplatform producing personalized vaccine against CRC.

Язык: Английский

---

Biomimetic Platelet‐Cloaked Nanoparticles for the Delivery of Anti‐Inflammatory Curcumin in the Treatment of Atherosclerosis

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(15)

Опубликована: Март 19, 2024

Atherosclerosis still represents a major driver of cardiovascular diseases worldwide. Together with accumulation lipids in the plaque, inflammation is recognized as one key players formation and development atherosclerotic plaque. Systemic anti-inflammatory treatments are successful reducing disease burden, but correlated severe side effects, underlining need for targeted formulations. In this work, curcumin chosen payload model further loaded lignin-based nanoparticles (NPs). The NPs then coated tannic acid (TA)- Fe (III) complex cloaked fragments derived from platelet cell membrane, yielding homogenous size. two coatings increase interaction between cells, both endothelial macrophages, steady state or inflamed status. Furthermore, cytocompatible toward endothelial, smooth muscle immune while not inducing activation. efficacy demonstrated cells by real-time quantitative polymerase chain reaction ELISA assay where curcumin-loaded decrease expression Nf-κb, TGF-β1, IL-6, IL-1β lipopolysaccharide-inflamed cells. Overall, due to cell-NP interactions efficacy, these represent potential candidates treatment atherosclerosis.

Язык: Английский

---

Nanotechnology-enabled M2 macrophage polarization and ferroptosis inhibition for targeted inflammatory bowel disease treatment

Journal of Controlled Release, Год журнала: 2024, Номер 367, С. 339 - 353

Опубликована: Фев. 1, 2024

Язык: Английский

---

The emerging role of the gut microbiota and its application in inflammatory bowel disease

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117302 - 117302

Опубликована: Авг. 19, 2024

Inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis, is a complex disorder with an unknown cause. However, the dysbiosis of gut microbiome has been found to play role in IBD etiology, exacerbated immune responses defective intestinal barrier integrity. The can also be potential biomarker for several diseases, IBD. Currently, conventional treatments targeting pro-inflammatory cytokines pathways IBD-associated do not yield effective results. Other therapies that directly target dysbiotic outcomes are emerging. We review health its as diagnostic, prognostic, therapeutic This explores emerging advancements microbiome-associated alterations IBD, such nanoparticle or encapsulation delivery, fecal microbiota transplantation, nutritional therapies, microbiome/probiotic engineering, phage therapy, mesenchymal stem cells (MSCs), proteins, herbal formulas.

Язык: Английский

---

Applications of polymeric nanoparticles in drug delivery for glioblastoma

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 6, 2025

Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors, necessitating innovative therapeutic approaches. Polymer-based nanotechnology has emerged as a promising solution, offering precise drug delivery, enhanced blood-brain barrier (BBB) penetration, adaptability to tumor microenvironment (TME). This review explores diverse applications polymeric nanoparticles (NPs) in GBM treatment, including delivery chemotherapeutics, targeted therapeutics, immunotherapeutics, other agents for radiosensitization photodynamic therapy. Recent advances multifunctional polymer highlight their potential overcome challenges that brought, such heterogeneity tumor, BBB limitation, immunosuppressive TME, consideration biocompatibility safety. Meanwhile, future directions address these are also proposed. By addressing obstacles, polymer-based represents transformative strategy improving treatment outcomes, paving way more effective patient-specific therapies.

Язык: Английский

---

Glycogen-based pH and redox sensitive nanoparticles with ginsenoside Rh2 for effective treatment of ulcerative colitis

Biomaterials, Год журнала: 2021, Номер 280, С. 121077 - 121077

Опубликована: Авг. 20, 2021

Язык: Английский

---

Targeting Engineered Nanoparticles for Breast Cancer Therapy

Pharmaceutics, Год журнала: 2021, Номер 13(11), С. 1829 - 1829

Опубликована: Ноя. 1, 2021

Breast cancer (BC) is the second most common in women globally after lung cancer. Presently, important approach for BC treatment consists of surgery, followed by radiotherapy and chemotherapy. The latter therapeutic methods are often unsuccessful because their various side effects damage incurred to healthy tissues organs. Currently, numerous nanoparticles (NPs) have been identified synthesized selectively target cells without causing any impairments adjacent normal or Based on an exploratory study, this comprehensive review aims provide information engineered NPs payloads as promising tools BC. Therapeutic drugs natural bioactive compounds generally incorporate ideal sizes shapes enhance solubility, circulatory half-life, biodistribution, while reducing immunogenicity. Furthermore, ligands such peptides, antibodies, nucleic acids surface precisely cells. Studies synthesis impact were obtained from PubMed, Science Direct, Google Scholar. This provides insights importance methodology validation a next-generation platform with preventive against

Язык: Английский

---